|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the association of insulin sensitivity with the c.825C>T variant of the g-protein beta-3 subunit (GNB3), a candidate gene of hypertension, in families of Mexican-American hypertensive patients.
|
18413224 |
2008 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
No statistical significant association between hypertension and the C825T polymorphism was found during the follow-up.
|
20539277 |
2010 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the C825T polymorphism of the beta 3 subunit of G protein is significantly and independently associated with the occurrence of hypertension in the study population.
|
29853161 |
2018 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common C825T polymorphism in the gene GNB3, which encodes the beta 3 subunit of heterotrimeric G proteins, was identified in cell lines from patients with hypertension.
|
15660499 |
2005 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A recent study has revealed that a novel variant (C825T) in exon 10 of the gene encoding the beta3 subunit of heterotrimetric G proteins (GNB3) is a genetic factor predisposing to hypertension in Caucasians.
|
10701813 |
2000 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our overall results suggest null association of α-adducin G460T and GNB3 C825T polymorphisms with hypertension in Chinese but indicate local marginal significance of C825T, as a putative salt-sensitive switch, in southern Chinese.
|
21364877 |
2011 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
BP values in young male whites increased significantly with increasing BMI values but were independent of the C825T polymorphism, suggesting that hypertension associated with the 825T allele could be a consequence of obesity.
|
10477144 |
1999 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The further adjustment for hypertension abolished the association between the GNB3 C825T variant and DPN (OR = 1.95, p = 0.18).
|
19597293 |
2009 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A C825T polymorphism of a gene encoding the beta3 subunit of heterotrimeric G proteins (GNB3) was reported to be associated with several pathological conditions, such as hypertension and depressive disorder.
|
12075862 |
2002 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, 3 physiologically important candidate gene mutations (angiotensinogen A[-6], alpha-Adducin Gly460Trp, and G-Protein beta(3)-subunit C825T) were examined for their association with hypertension status in a sample of 904 African Americans from Jackson, Mississippi.
|
10856280 |
2000 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C825T dimorphism of the gene encoding the human G protein beta3 subunit (GNB3) is associated with hypertension and obesity.
|
12624279 |
2003 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
SNP rs2301339 is perfectly linked in linkage disequilibrium (LD) with C825T (rs5443) which has been associated with hypertension in Caucasian, but inconsistent in Asian populations.
|
22534794 |
2012 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the study was to verify the hypothesis if the interaction between the G protein beta3 subunit (GNB3) C825T polymorphism and ACE I/D polymorphism could lead to the disclosure of increased activity of sodium-proton exchanger and hypertension.
|
16314202 |
2006 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To evaluate whether this variant is associated with hypertension or blood pressure in other human samples, we genotyped 447 young adult Oji-Cree for the GNB3 C825T variation.
|
9774364 |
1998 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C825T polymorphism in the gene coding for the beta3 subunit of G proteins (GNB3) has been shown to be associated with several phenotypes such as hypertension, obesity, and diabetes mellitus comprising the metabolic syndrome.
|
15033462 |
2004 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the study was to examine the association between the G protein β3 subunit C825T polymorphism, associated with cardiovascular risk factors like hypertension (HT) and obesity and microalbuminuria (MA), reflecting the endothelial dysfunction in the atherosclerotic process.
|
20577224 |
2010 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the C825T polymorphism influences lipid metabolism and is not associated with hypertension, obesity, insulin resistance, diabetes, diabetic complications, or diabetic therapies.
|
17161225 |
2007 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphism C825T of the gene encoding the G-protein beta 3-subunit (GNB3) was found to be associated with an increased prevalence of hypertension in a number of studies.
|
16487269 |
2006 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The 825C/T polymorphism of the G-protein subunit beta3 is not related to hypertension.
|
10334807 |
1999 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition to these polymorphisms, the T(-344)C polymorphism in the promoter of the aldosterone synthase gene (CYP11B2) and the C825T polymorphism of the G-protein beta3 subunit gene (GNB3) are considered candidates for the genetic risk of salt-sensitive hypertension.
|
12924618 |
2003 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A polymorphism (C825T) in exon 10 of the gene encoding the beta 3 subunit of heterotrimeric G proteins (GN beta 3) has recently been described, and the T allele was found to be associated with late-onset hypertension.
|
10200987 |
1999 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
There have been few studies investigating interactions of G-protein beta3 subunit (<i>GNB3</i>) C825T (rs5443) and dietary sodium intake on the risk of hypertension, i.e., BP salt sensitivity.
|
29848945 |
2018 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study focused on 3 genetic polymorphisms that have previously been implicated in hypertension: the alpha-adducin (ADD1/Gly460Trp), beta1-adrenoreceptor (ADRB1/Arg389Gly), and G-protein beta3 subunit (GNB3/C825T) gene polymorphisms.
|
15055253 |
2004 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the present study was to further investigate the association of the GNB3 C825T allele status with arterial hypertension in a large population-based sample and its association with specific end organ damage, i.e. myocardial infarction (MI).
|
11230982 |
2001 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TT genotype of the C825T GNB3 gene polymorphism was found to be a significant risk factor for the incidence of CVD and stroke independent of hypertension and other established CVD risk factors in a Japanese population.
|
23595158 |
2013 |