|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the C825T polymorphism of the beta 3 subunit of G protein is significantly and independently associated with the occurrence of hypertension in the study population.
|
29853161 |
2018 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
There have been few studies investigating interactions of G-protein beta3 subunit (<i>GNB3</i>) C825T (rs5443) and dietary sodium intake on the risk of hypertension, i.e., BP salt sensitivity.
|
29848945 |
2018 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Synergistic Effects of ACE Insertion/Deletion and GNB3 C825T Polymorphisms on the Efficacy of PDE-5 Inhibitor in Patients with Pulmonary Hypertension.
|
26821322 |
2016 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C825T polymorphism of the gene encoding the human G protein beta-3 subunit (GNB3) is associated with hypertension and obesity.
|
25463071 |
2014 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TT genotype of the C825T GNB3 gene polymorphism was found to be a significant risk factor for the incidence of CVD and stroke independent of hypertension and other established CVD risk factors in a Japanese population.
|
23595158 |
2013 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C825T polymorphism of the G-protein β3 subunit gene and its association with hypertension and stroke: an updated meta-analysis.
|
23799054 |
2013 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We assessed whether distributions of 3 single nucleotide polymorphisms in genes coding for components of G protein signaling pathways that have been associated with hypertension differ between women with preeclampsia and normotensive pregnant women; the G protein β3 subunit gene (GNB3) C825T polymorphism (rs5443), the angiotensin II type 1 receptor gene (AGTR1) 3'UTR A1166C polymorphism (rs5186), and the regulator of G protein signaling 2 gene (RGS2) 3'UTR C1114G polymorphism (rs4606).
|
23339167 |
2013 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
SNP rs2301339 is perfectly linked in linkage disequilibrium (LD) with C825T (rs5443) which has been associated with hypertension in Caucasian, but inconsistent in Asian populations.
|
22534794 |
2012 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our overall results suggest null association of α-adducin G460T and GNB3 C825T polymorphisms with hypertension in Chinese but indicate local marginal significance of C825T, as a putative salt-sensitive switch, in southern Chinese.
|
21364877 |
2011 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
T allele frequency in overall population showed significant association with hypertension for C825T (0.0134).
|
21473734 |
2011 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The GNB3 C825T polymorphism as a pharmacogenetic marker in the treatment of hypertension, obesity, and depression.
|
21709600 |
2011 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
No statistical significant association between hypertension and the C825T polymorphism was found during the follow-up.
|
20539277 |
2010 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the study was to examine the association between the G protein β3 subunit C825T polymorphism, associated with cardiovascular risk factors like hypertension (HT) and obesity and microalbuminuria (MA), reflecting the endothelial dysfunction in the atherosclerotic process.
|
20577224 |
2010 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The G-protein β 3(GNB3) C825T polymorphism has been linked with hypertension, salt sensitivity and multiple diseases.
|
21198262 |
2010 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The further adjustment for hypertension abolished the association between the GNB3 C825T variant and DPN (OR = 1.95, p = 0.18).
|
19597293 |
2009 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the association of insulin sensitivity with the c.825C>T variant of the g-protein beta-3 subunit (GNB3), a candidate gene of hypertension, in families of Mexican-American hypertensive patients.
|
18413224 |
2008 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the C825T polymorphism influences lipid metabolism and is not associated with hypertension, obesity, insulin resistance, diabetes, diabetic complications, or diabetic therapies.
|
17161225 |
2007 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that the variation within the GNB3 gene may interact with physical activity level to influence obesity status and, together with obesity and physical activity, the GNB3 825C>T variant may influence hypertension prevalence in AAs.
|
17299380 |
2007 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the study was to verify the hypothesis if the interaction between the G protein beta3 subunit (GNB3) C825T polymorphism and ACE I/D polymorphism could lead to the disclosure of increased activity of sodium-proton exchanger and hypertension.
|
16314202 |
2006 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphism C825T of the gene encoding the G-protein beta 3-subunit (GNB3) was found to be associated with an increased prevalence of hypertension in a number of studies.
|
16487269 |
2006 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common C825T polymorphism in the gene GNB3, which encodes the beta 3 subunit of heterotrimeric G proteins, was identified in cell lines from patients with hypertension.
|
15660499 |
2005 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the biochemical and genetic background of this disease we investigated the genotypes for two polymorphisms associated with hypertension: TH01, a tetrameric microsatellite in the tyrosine hydroxylase gene and the single nucleotide polymorphism C825T in the GNB3 gene in 116 sudden deaths from MI (78 males, 38 females) and in a control group of 137 deaths from natural causes other than MI (52 males, 85 females).
|
16139102 |
2005 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, our study suggests that G(-350)A is a potential functional polymorphism that may be related to hypertension, whereas the C825T and C1429T polymorphisms are not associated with hypertension in the northern Chinese Han population.
|
15996174 |
2005 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C825T polymorphism in the gene coding for the beta3 subunit of G proteins (GNB3) has been shown to be associated with several phenotypes such as hypertension, obesity, and diabetes mellitus comprising the metabolic syndrome.
|
15033462 |
2004 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study focused on 3 genetic polymorphisms that have previously been implicated in hypertension: the alpha-adducin (ADD1/Gly460Trp), beta1-adrenoreceptor (ADRB1/Arg389Gly), and G-protein beta3 subunit (GNB3/C825T) gene polymorphisms.
|
15055253 |
2004 |