rs5443, CDCA3;GNB3

N. diseases: 106
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE In the current study, 729 patients (CC, n = 332; CT, n = 313; TT, n = 84) with essential hypertension were genotyped for C825T polymorphism of the GNB3 gene and followed 8 years for major adverse cardiovascular events (MACEs) which include stroke, the onset of coronary artery disease (CAD), and all-cause death. 28067546 2017
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE In summary, the present meta-analysis indicated the GNB3 C825T polymorphism is related to increased EH exclusively in Caucasians. 28540932 2017
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE The GNB3 C825T splice variant is associated with the DBP-lowering effect of telmisartan but not amlodipine in Chinese EH patients. 26712426 2016
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE Essential hypertension patients were genotyped for 11 polymorphisms of essential hypertension susceptibility genes including ADD1 (rs4961), GNB3 (rs5443, rs16932941), NOS3 (rs1799983, rs2070744), ACE (rs5186), AGTR1 (rs5186), AGT (rs699, rs4762), MR (rs5534), and TGFB1 (rs1800471). 26335431 2015
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE Meta-analysis results suggest that the GNB3-C825T polymorphism is associated with risk of EH in the overall population, the Caucasians and the Chinese. 24346074 2013
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE There was no significant association identified between GNB3-C825T polymorphism and EH in Han Chinese population. 22714918 2012
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE G-protein beta 3 subunit (GNB3) C825T (rs5443) single nucleotide polymorphism (SNP) has been implicated as a risk factor for essential hypertension in the general population. 19811352 2009
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE The GNB3 C825T polymorphism and essential hypertension: a meta-analysis of 34 studies including 14,094 cases and 17,760 controls. 17278960 2007
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE Case-control association analysis showed a significant association between EH and both the ALDH2 (Lys487Glu) and GNB3 (C825T) variants. 17785925 2007
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans. 17066084 2007
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE GNB3 C825T and ACE I/D polymorphisms on the sodium-proton exchanger and the prevalence of essential hypertension in males. 16314202 2006
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE GNB3 825 C>T is likely to be a significant risk factor for LVH but not for EH in the Emirati population, thereby strengthening the view that LVH is genetically a separate clinical entity. 15614196 2005
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE GNB3 gene C825T and ACE gene I/D polymorphisms in essential hypertension in a Kazakh genetic isolate. 15042113 2004
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE The T allele of the G protein beta3 subunit (GNB3) C825T polymorphism has been associated with increased signal transduction, increased activity of the kidney Na+/H+ exchanger, and also with late-onset essential hypertension. 15200440 2004
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE The 825T-allele of the C825T polymorphism in GNB3, the gene for the G protein beta3 subunit, has been reported to be associated with essential hypertension and obesity. 12730030 2003
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE The G-protein beta3 subunit (GNB3) C825T polymorphism was detected through a classical candidate gene approach using cell lines with enhanced G-protein activation from patients with essential hypertension. 12530935 2003
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE Recently, a C825T polymorphism in the gene coding for the beta3 subunit of G proteins (GNB3) has been described in cells from patients with essential hypertension and enhanced Na+/H+ exchange activity. 12113397 2002
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE Lack of association of G-protein subunit gene C825T polymorphism with left ventricular hypertrophy in essential hypertension. 12011775 2002
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE Thus, the C825T polymorphism of the G protein beta(3)-subunit may help identify patients with essential hypertension who are more responsive to diuretic therapy. 11230366 2001
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE GNB3 825C-->T is not associated with the phenotype of hypertensive crisis in patients suffering from essential hypertension. 11008983 2000
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE In 34 white patients with established mild to moderate essential hypertension (World Health Organization stage I or II, mean age 52 +/- 9 years) genotype analysis of GNB3 C825T polymorphism, insertion/deletion polymorphism of the ACE gene and 1166 A/C polymorphism of the AT1 receptor gene was performed. 10526907 1999
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE We conclude that the 825C/T polymorphism of the GNB3 gene did not contribute in any important way to the risk of essential hypertension or MI in these studies. 10334807 1999