rs5522, NR3C2

N. diseases: 19
Disease: Depressive disorder ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.050 GeneticVariation BEFREE To investigate the hypothesis that the MR sex-dependently influences the relation between childhood maltreatment and depression, we investigated three common and functional MR haplotypes (GA, CA, and CG haplotype, based on rs5522 and rs2070951) in a population-based cohort (N = 665) and an independent clinical cohort from the Netherlands Study of Depression and Anxiety (NESDA) (N = 1639). 25686805 2015
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.050 GeneticVariation BEFREE There is evidence that the Val allele of the MRI180V polymorphism (rs5522) increases the risk of depression, attention and cognitive deficits. 22584804 2013
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.050 GeneticVariation BEFREE In an elderly cohort, one of the functional MR gene variants, MR-I180V, associated with higher feelings of depression. 21164267 2011
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.050 GeneticVariation BEFREE Common functional MR single nucleotide polymorphisms (SNPs; MR -2G/C and I180V) and haplotypes were tested for association with variability in the CAR in a large cohort (Netherlands Study of Depression and Anxiety, NESDA) of patients diagnosed with a lifetime major depressive disorder (MDD). 20884124 2011
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.050 GeneticVariation BEFREE Future studies are warranted to evaluate whether rs5522 genotype interacts with naturalistic stressors to increase the risk of depression and whether stress-induced anhedonia might moderate such risk. 20528958 2010