rs5522, NR3C2

N. diseases: 19
Disease: Depressive Symptoms ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.010 GeneticVariation BEFREE The mineralocorticoid receptor (MR) determines the sensitivity of the stress response, and the missense iso/val polymorphism (Ile180Val, rs5522) of the MR gene (NR3C2) has been associated with enhanced physiological stress responses, elevated depressive symptoms and reduced cortisol-induced MR gene expression. 20528958 2010