|
Depressed mood
|
|
0.050 |
GeneticVariation
|
BEFREE |
To investigate the hypothesis that the MR sex-dependently influences the relation between childhood maltreatment and depression, we investigated three common and functional MR haplotypes (GA, CA, and CG haplotype, based on rs5522 and rs2070951) in a population-based cohort (N = 665) and an independent clinical cohort from the Netherlands Study of Depression and Anxiety (NESDA) (N = 1639).
|
25686805 |
2015 |
|
Depressive disorder
|
|
0.050 |
GeneticVariation
|
BEFREE |
To investigate the hypothesis that the MR sex-dependently influences the relation between childhood maltreatment and depression, we investigated three common and functional MR haplotypes (GA, CA, and CG haplotype, based on rs5522 and rs2070951) in a population-based cohort (N = 665) and an independent clinical cohort from the Netherlands Study of Depression and Anxiety (NESDA) (N = 1639).
|
25686805 |
2015 |
|
Mental Depression
|
|
0.050 |
GeneticVariation
|
BEFREE |
To investigate the hypothesis that the MR sex-dependently influences the relation between childhood maltreatment and depression, we investigated three common and functional MR haplotypes (GA, CA, and CG haplotype, based on rs5522 and rs2070951) in a population-based cohort (N = 665) and an independent clinical cohort from the Netherlands Study of Depression and Anxiety (NESDA) (N = 1639).
|
25686805 |
2015 |
|
Depressive disorder
|
|
0.050 |
GeneticVariation
|
BEFREE |
There is evidence that the Val allele of the MRI180V polymorphism (rs5522) increases the risk of depression, attention and cognitive deficits.
|
22584804 |
2013 |
|
Mental Depression
|
|
0.050 |
GeneticVariation
|
BEFREE |
There is evidence that the Val allele of the MRI180V polymorphism (rs5522) increases the risk of depression, attention and cognitive deficits.
|
22584804 |
2013 |
|
Depressed mood
|
|
0.050 |
GeneticVariation
|
BEFREE |
There is evidence that the Val allele of the MRI180V polymorphism (rs5522) increases the risk of depression, attention and cognitive deficits.
|
22584804 |
2013 |
|
Mental Depression
|
|
0.050 |
GeneticVariation
|
BEFREE |
Common functional MR single nucleotide polymorphisms (SNPs; MR -2G/C and I180V) and haplotypes were tested for association with variability in the CAR in a large cohort (Netherlands Study of Depression and Anxiety, NESDA) of patients diagnosed with a lifetime major depressive disorder (MDD).
|
20884124 |
2011 |
|
Depressive disorder
|
|
0.050 |
GeneticVariation
|
BEFREE |
In an elderly cohort, one of the functional MR gene variants, MR-I180V, associated with higher feelings of depression.
|
21164267 |
2011 |
|
Depressed mood
|
|
0.050 |
GeneticVariation
|
BEFREE |
In an elderly cohort, one of the functional MR gene variants, MR-I180V, associated with higher feelings of depression.
|
21164267 |
2011 |
|
Depressed mood
|
|
0.050 |
GeneticVariation
|
BEFREE |
Common functional MR single nucleotide polymorphisms (SNPs; MR -2G/C and I180V) and haplotypes were tested for association with variability in the CAR in a large cohort (Netherlands Study of Depression and Anxiety, NESDA) of patients diagnosed with a lifetime major depressive disorder (MDD).
|
20884124 |
2011 |
|
Depressive disorder
|
|
0.050 |
GeneticVariation
|
BEFREE |
Common functional MR single nucleotide polymorphisms (SNPs; MR -2G/C and I180V) and haplotypes were tested for association with variability in the CAR in a large cohort (Netherlands Study of Depression and Anxiety, NESDA) of patients diagnosed with a lifetime major depressive disorder (MDD).
|
20884124 |
2011 |
|
Mental Depression
|
|
0.050 |
GeneticVariation
|
BEFREE |
In an elderly cohort, one of the functional MR gene variants, MR-I180V, associated with higher feelings of depression.
|
21164267 |
2011 |
|
Mental Depression
|
|
0.050 |
GeneticVariation
|
BEFREE |
Future studies are warranted to evaluate whether rs5522 genotype interacts with naturalistic stressors to increase the risk of depression and whether stress-induced anhedonia might moderate such risk.
|
20528958 |
2010 |
|
Depressed mood
|
|
0.050 |
GeneticVariation
|
BEFREE |
Future studies are warranted to evaluate whether rs5522 genotype interacts with naturalistic stressors to increase the risk of depression and whether stress-induced anhedonia might moderate such risk.
|
20528958 |
2010 |
|
Depressive disorder
|
|
0.050 |
GeneticVariation
|
BEFREE |
Future studies are warranted to evaluate whether rs5522 genotype interacts with naturalistic stressors to increase the risk of depression and whether stress-induced anhedonia might moderate such risk.
|
20528958 |
2010 |
|
Hypertensive disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Genetic variation in <i>MR</i> (rs5522) and comorbidity with hypertension were significantly and potentially associated with prognosis when treated with ADT, respectively.
|
30619769 |
2018 |
|
Hypertensive disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The aim of this study was to analyze the association between the MR p.I180V polymorphism with hypertension and markers of cardiovascular risk.
|
19955850 |
2010 |
|
Hypertensive disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
One haplotype, which included the G allele of the rs5522</span>, was also associated with reduced risk of HTN and four haplotypes which included the A allele were associated with increased risk of HTN.
|
19325532 |
2009 |
|
Major Depressive Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Previous research found that variants of the glucocorticoid receptor (GR) (9β, ER22/23EK, BclI, TthIIIl, NR3C1-1 and N363S) and mineralocorticoid receptor (MR) gene polymorphism (-2 C/G and I180V) are associated with both glucocorticoid (GC) sensitivity and major depressive disorder (MDD).
|
25765757 |
2015 |
|
Major Depressive Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Common functional MR single nucleotide polymorphisms (SNPs; MR -2G/C and I180V) and haplotypes were tested for association with variability in the CAR in a large cohort (Netherlands Study of Depression and Anxiety, NESDA) of patients diagnosed with a lifetime major depressive disorder (MDD).
|
20884124 |
2011 |
|
High altitude pulmonary edema
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs5522 polymorphism of the NR3C2 gene was associated with HAPE </span>susceptibility in Chinese subjects.
|
30292562 |
2018 |
|
Chronic central serous chorioretinopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, the GA haplotype of single-nucleotide polymorphisms rs2070951 and rs5522 in NR3C2 conferred risk for cCSC (odds ratio, 1.39; 95% CI, 1.15-1.68; P = .004), whereas the CA haplotype decreased risk for cCSC (odds ratio, 0.72; 95% CI, 0.60-0.87; P < .001).
|
28334414 |
2017 |
|
Left Ventricular Hypertrophy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Left ventricular hypertrophy (LVH) was more prevalent in G carriers than AA homozygous for rs5522 but not for rs2070951 in RHTN.
|
26049084 |
2016 |
|
Resistant hypertensive disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of Mineralocorticoid Receptor Polymorphism I180V With Left Ventricular Hypertrophy in Resistant Hypertension.
|
26049084 |
2016 |
|
Abnormal behavior
|
|
0.010 |
GeneticVariation
|
BEFREE |
Interaction between GR and MR polymorphisms and antenatal glucocorticoid treatment was observed, with poorer IQ scores for exposed N363S carriers; poorer intellectual subdomain scores for exposed I180V-carriers; more favorable total problem behavior scores for exposed R23K carriers.
|
25406795 |
2015 |