rs55705857, CCDC26

N. diseases: 16
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Glioma
CUI: C0017638
Disease: Glioma
0.760 GeneticVariation BEFREE IDH1/2 mutated glioma has been associated with a germline risk variant, the rs55705857 G allele. 30823903 2019
Glioma
CUI: C0017638
Disease: Glioma
0.760 GeneticVariation BEFREE Of the 6 variants located in 8q24, 2 have strong significant associations with the risk of glioma, including rs4295627 (P = .003, odds ratio [OR] = 1.21), rs55705857 (P = 2.31 × 10, OR = 3.54). 31277128 2019
Glioma
CUI: C0017638
Disease: Glioma
0.760 GeneticVariation BEFREE Taken into consideration the limitations of this study, the present findings suggest a possible participation of rs891835, rs6470745, and rs55705857 as risk factors to develop glioma. 30778791 2019
Glioma
CUI: C0017638
Disease: Glioma
0.760 GeneticVariation GWASCAT Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21. 29743610 2018
Glioma
CUI: C0017638
Disease: Glioma
0.760 GeneticVariation GWASCAT Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. 28346443 2017
Glioma
CUI: C0017638
Disease: Glioma
0.760 GeneticVariation BEFREE IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation. 27282637 2016
Glioma
CUI: C0017638
Disease: Glioma
0.760 GeneticVariation GWASCAT Genome-wide association study identifies multiple susceptibility loci for glioma. 26424050 2015
Glioma
CUI: C0017638
Disease: Glioma
0.760 GeneticVariation BEFREE We also adjusted for the recently discovered 8q24 glioma risk locus rs55705857 G allele. 23361564 2013
Glioma
CUI: C0017638
Disease: Glioma
0.760 GeneticVariation BEFREE Analysis by glioma subtype showed the association with rs55705857 confined to non-glioblastoma multiforme (non-GBM) tumours (P = 1.07 × 10(-67)). 23399484 2013
Glioblastoma Multiforme
CUI: C1621958
Disease: Glioblastoma Multiforme
0.710 GeneticVariation GWASCAT Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age. 30152087 2018
Glioblastoma
CUI: C0017636
Disease: Glioblastoma
0.710 GeneticVariation GWASCAT Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age. 30152087 2018
Glioblastoma Multiforme
CUI: C1621958
Disease: Glioblastoma Multiforme
0.710 GeneticVariation GWASCAT Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. 28346443 2017
Glioblastoma
CUI: C0017636
Disease: Glioblastoma
0.710 GeneticVariation GWASCAT Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. 28346443 2017
Glioblastoma Multiforme
CUI: C1621958
Disease: Glioblastoma Multiforme
0.710 GeneticVariation BEFREE Analysis by glioma subtype showed the association with rs55705857 confined to non-glioblastoma multiforme (non-GBM) tumours (P = 1.07 × 10(-67)). 23399484 2013
Glioblastoma
CUI: C0017636
Disease: Glioblastoma
0.710 GeneticVariation BEFREE Analysis by glioma subtype showed the association with rs55705857 confined to non-glioblastoma multiforme (non-GBM) tumours (P = 1.07 × 10(-67)). 23399484 2013
Central Nervous System Neoplasms
CUI: C0085136
Disease: Central Nervous System Neoplasms
0.700 GeneticVariation GWASCAT Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. 28346443 2017
Central Nervous System Neoplasms
CUI: C0085136
Disease: Central Nervous System Neoplasms
0.700 GeneticVariation GWASCAT Genome-wide association study identifies multiple susceptibility loci for glioma. 26424050 2015
Neoplasms
CUI: C0027651
Disease: Neoplasms
0.030 GeneticVariation BEFREE We performed whole exome sequencing on matched tumor and normal DNA from all available short-term (STS) and long-term survivors (LTS) who received RT+PCV. hTERT status and rs55705857 genotypes (G-allele) were analyzed in both cohorts. 28388591 2017
Neoplasms
CUI: C0027651
Disease: Neoplasms
0.030 GeneticVariation BEFREE Recently published research suggests that historically used clinical variables are not sufficient (and are likely inferior) prognostic and predictive indicators relative to information provided by recently discovered tumor markers (e.g., 1p/19q deletion and IDH1 or IDH2 mutation status), tumor expression profiles (e.g., the proneural profile) and/or constitutive genotype (e.g., rs55705857 on 8q24.21). 25552286 2015
Neoplasms
CUI: C0027651
Disease: Neoplasms
0.030 GeneticVariation BEFREE After stratifying by histological and tumor genetic subtype, the most significant associations of rs55705857 were with oligodendroglial tumors and gliomas with mutant IDH1 or IDH2 (odds ratio (OR)=5.1, P=1.1×10(-31) and OR=4.8, P=6.6×10(-22), respectively). 22922872 2012
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.010 GeneticVariation BEFREE First-degree relatives of rs55705857 G allele carriers were at significantly increased risk for developing cancer (RR = 1.72, p = 0.045, CI 1.02-2.94), and specifically for oligodendroglioma (RR = 57.61, p = 0.017, CI 2.96-320.98) or prostate cancer (RR = 4.10, p = 0.008, CI 1.62-9.58); relatives of individuals without the G allele were not at increased risk. 30823903 2019
Adult Oligodendroglioma
CUI: C0279070
Disease: Adult Oligodendroglioma
0.010 GeneticVariation BEFREE First-degree relatives of rs55705857 G allele carriers were at significantly increased risk for developing cancer (RR = 1.72, p = 0.045, CI 1.02-2.94), and specifically for oligodendroglioma (RR = 57.61, p = 0.017, CI 2.96-320.98) or prostate cancer (RR = 4.10, p = 0.008, CI 1.62-9.58); relatives of individuals without the G allele were not at increased risk. 30823903 2019
Childhood Oligodendroglioma
CUI: C0280475
Disease: Childhood Oligodendroglioma
0.010 GeneticVariation BEFREE First-degree relatives of rs55705857 G allele carriers were at significantly increased risk for developing cancer (RR = 1.72, p = 0.045, CI 1.02-2.94), and specifically for oligodendroglioma (RR = 57.61, p = 0.017, CI 2.96-320.98) or prostate cancer (RR = 4.10, p = 0.008, CI 1.62-9.58); relatives of individuals without the G allele were not at increased risk. 30823903 2019
Hereditary Malignant Neoplasm
CUI: C1333600
Disease: Hereditary Malignant Neoplasm
0.010 GeneticVariation BEFREE The contribution of the rs55705857 G allele to familial cancer risk as estimated in the Utah population database. 30823903 2019
Well Differentiated Oligodendroglioma
0.010 GeneticVariation BEFREE First-degree relatives of rs55705857 G allele carriers were at significantly increased risk for developing cancer (RR = 1.72, p = 0.045, CI 1.02-2.94), and specifically for oligodendroglioma (RR = 57.61, p = 0.017, CI 2.96-320.98) or prostate cancer (RR = 4.10, p = 0.008, CI 1.62-9.58); relatives of individuals without the G allele were not at increased risk. 30823903 2019