Glioma
|
|
0.760 |
GeneticVariation
|
BEFREE |
IDH1/2 mutated glioma has been associated with a germline risk variant, the rs55705857 G allele.
|
30823903 |
2019 |
Glioma
|
|
0.760 |
GeneticVariation
|
BEFREE |
Of the 6 variants located in 8q24, 2 have strong significant associations with the risk of glioma, including rs4295627 (P = .003, odds ratio [OR] = 1.21), rs55705857 (P = 2.31 × 10, OR = 3.54).
|
31277128 |
2019 |
Glioma
|
|
0.760 |
GeneticVariation
|
BEFREE |
Taken into consideration the limitations of this study, the present findings suggest a possible participation of rs891835, rs6470745, and rs55705857 as risk factors to develop glioma.
|
30778791 |
2019 |
Glioma
|
|
0.760 |
GeneticVariation
|
GWASCAT |
Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.
|
29743610 |
2018 |
Glioma
|
|
0.760 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
Glioma
|
|
0.760 |
GeneticVariation
|
BEFREE |
IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation.
|
27282637 |
2016 |
Glioma
|
|
0.760 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies multiple susceptibility loci for glioma.
|
26424050 |
2015 |
Glioma
|
|
0.760 |
GeneticVariation
|
BEFREE |
We also adjusted for the recently discovered 8q24 glioma risk locus rs55705857 G allele.
|
23361564 |
2013 |
Glioma
|
|
0.760 |
GeneticVariation
|
BEFREE |
Analysis by glioma subtype showed the association with rs55705857 confined to non-glioblastoma multiforme (non-GBM) tumours (P = 1.07 × 10(-67)).
|
23399484 |
2013 |
Glioblastoma Multiforme
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.
|
30152087 |
2018 |
Glioblastoma
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.
|
30152087 |
2018 |
Glioblastoma Multiforme
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
Glioblastoma
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
Glioblastoma Multiforme
|
|
0.710 |
GeneticVariation
|
BEFREE |
Analysis by glioma subtype showed the association with rs55705857 confined to non-glioblastoma multiforme (non-GBM) tumours (P = 1.07 × 10(-67)).
|
23399484 |
2013 |
Glioblastoma
|
|
0.710 |
GeneticVariation
|
BEFREE |
Analysis by glioma subtype showed the association with rs55705857 confined to non-glioblastoma multiforme (non-GBM) tumours (P = 1.07 × 10(-67)).
|
23399484 |
2013 |
Central Nervous System Neoplasms
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
|
28346443 |
2017 |
Central Nervous System Neoplasms
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies multiple susceptibility loci for glioma.
|
26424050 |
2015 |
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
We performed whole exome sequencing on matched tumor and normal DNA from all available short-term (STS) and long-term survivors (LTS) who received RT+PCV. hTERT status and rs55705857 genotypes (G-allele) were analyzed in both cohorts.
|
28388591 |
2017 |
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Recently published research suggests that historically used clinical variables are not sufficient (and are likely inferior) prognostic and predictive indicators relative to information provided by recently discovered tumor markers (e.g., 1p/19q deletion and IDH1 or IDH2 mutation status), tumor expression profiles (e.g., the proneural profile) and/or constitutive genotype (e.g., rs55705857 on 8q24.21).
|
25552286 |
2015 |
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
After stratifying by histological and tumor genetic subtype, the most significant associations of rs55705857 were with oligodendroglial tumors and gliomas with mutant IDH1 or IDH2 (odds ratio (OR)=5.1, P=1.1×10(-31) and OR=4.8, P=6.6×10(-22), respectively).
|
22922872 |
2012 |
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
First-degree relatives of rs55705857 G allele carriers were at significantly increased risk for developing cancer (RR = 1.72, p = 0.045, CI 1.02-2.94), and specifically for oligodendroglioma (RR = 57.61, p = 0.017, CI 2.96-320.98) or prostate cancer (RR = 4.10, p = 0.008, CI 1.62-9.58); relatives of individuals without the G allele were not at increased risk.
|
30823903 |
2019 |
Adult Oligodendroglioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
First-degree relatives of rs55705857 G allele carriers were at significantly increased risk for developing cancer (RR = 1.72, p = 0.045, CI 1.02-2.94), and specifically for oligodendroglioma (RR = 57.61, p = 0.017, CI 2.96-320.98) or prostate cancer (RR = 4.10, p = 0.008, CI 1.62-9.58); relatives of individuals without the G allele were not at increased risk.
|
30823903 |
2019 |
Childhood Oligodendroglioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
First-degree relatives of rs55705857 G allele carriers were at significantly increased risk for developing cancer (RR = 1.72, p = 0.045, CI 1.02-2.94), and specifically for oligodendroglioma (RR = 57.61, p = 0.017, CI 2.96-320.98) or prostate cancer (RR = 4.10, p = 0.008, CI 1.62-9.58); relatives of individuals without the G allele were not at increased risk.
|
30823903 |
2019 |
Hereditary Malignant Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
The contribution of the rs55705857 G allele to familial cancer risk as estimated in the Utah population database.
|
30823903 |
2019 |
Well Differentiated Oligodendroglioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
First-degree relatives of rs55705857 G allele carriers were at significantly increased risk for developing cancer (RR = 1.72, p = 0.045, CI 1.02-2.94), and specifically for oligodendroglioma (RR = 57.61, p = 0.017, CI 2.96-320.98) or prostate cancer (RR = 4.10, p = 0.008, CI 1.62-9.58); relatives of individuals without the G allele were not at increased risk.
|
30823903 |
2019 |