|
Fasting blood sugar result
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
|
22885924 |
2012 |
|
Calcification of coronary artery
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
|
22916037 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our meta-analyses demonstrate that all three allele variants of G6PC2 (rs560887, rs16856187 and rs573225) are associated with elevated FG, with two variants (rs560887 in the Caucasians subgroup and rs16856187 under the allele and dominant model) being associated with T2D as well.
|
28704540 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
The evidence that the variants GCK rs1799884, GCKR rs780094, MTNR1B rs10830963 and G6PC2 rs560887, which are related to fasting plasma glucose levels, increase the risk of type 2 diabetes mellitus (T2DM) is contradictory.
|
23840762 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
Furthermore, we examined rs560887 for association with impaired fasting glycaemia (IFG), impaired glucose tolerance (IGT), type 2 diabetes and components of the metabolic syndrome.
|
19669124 |
2009 |
|
Monogenic diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
The study group included 129 children with GCK-MODY from the Polish Registry of Monogenic Diabetes and 395 with type 1 diabetes (T1DM), in whom we genotyped 2 SNPs in G6PC2 (rs560887) and GCKR (rs1260326).
|
24918535 |
2014 |
|
Monogenic diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
We determined the rs560887 genotype of patients with monogenic diabetes and glucokinase gene mutations (GCK-MODY) and correlated the genotypes with HbA(1c) levels.
|
22486180 |
2012 |
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
Glucose tolerance status and genotype interacted on insulin secretion (P=0.036), such that in NGT subjects, the minor A-allele of rs560887 was associated with decreased insulinogenic index (P=0.044), which was not the case in subjects with IFG/IGT (P=1.0).
|
20826583 |
2010 |
|
Impaired glucose tolerance
|
|
0.020 |
GeneticVariation
|
BEFREE |
Furthermore, we examined rs560887 for association with impaired fasting glycaemia (IFG), impaired glucose tolerance (IGT), type 2 diabetes and components of the metabolic syndrome.
|
19669124 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
The study group included 129 children with GCK-MODY from the Polish Registry of Monogenic Diabetes and 395 with type 1 diabetes (T1DM), in whom we genotyped 2 SNPs in G6PC2 (rs560887) and GCKR (rs1260326).
|
24918535 |
2014 |
|
Gestational Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6PC2, rs780094 of GCKR, rs7903146 of TCF7L2 and rs11708067 of ADCY5 showed nominally significant associations with GDM (OR range from 1.25 to 1.30).
|
23761423 |
2013 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Variation at the rs560887 locus of G6PC2 is associated with worse glycated haemoglobin levels in individuals with GCK mutations; GG homozygotes are more likely to meet diagnostic criteria for diabetes based on HbA(1c) level.
|
22486180 |
2012 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Variation at the rs560887 locus of G6PC2 is associated with worse glycated haemoglobin levels in individuals with GCK mutations; GG homozygotes are more likely to meet diagnostic criteria for diabetes based on HbA(1c) level.
|
22486180 |
2012 |