rs5743551, TLR1

N. diseases: 12
Disease: Sepsis ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Sepsis
CUI: C0243026
Disease: Sepsis
0.020 GeneticVariation BEFREE Since malaria exerts strong genetic pressure on the human genome, protection from parasitaemia associated with TLR1 rs5743551 may account for the maintenance of an allele associated with poor outcomes in Caucasians with sepsis. 26738805 2016
Sepsis
CUI: C0243026
Disease: Sepsis
0.020 GeneticVariation BEFREE We enrolled 1961 patients.TLR1-7202G (rs5743551) was associated with increased mortality after traumatic injury and this association was primarily observed in the subset of patients who developed sepsis [adjusted odds ratio (OR): 3.16; 95% confidence interval (CI): 1.43-6.97, P=0.004]. 23478521 2014