rs5743618, TLR1

N. diseases: 25
Disease: Leprosy ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Leprosy
CUI: C0023343
Disease: Leprosy
0.020 GeneticVariation BEFREE Conflicting findings about the association between leprosy and TLR1 variants N248S and I602S have been reported. 23547143 2013
Leprosy
CUI: C0023343
Disease: Leprosy
0.020 GeneticVariation BEFREE We have conducted an association analysis of more than 1,500 individuals from different case-control and family studies, and observed consistent associations between genetic variants in both TLR1 and the HLA-DRB1/DQA1 regions with susceptibility to leprosy (TLR1 I602S, case-control P = 5.7 x 10(-8), OR = 0.31, 95% CI = 0.20-0.48, and HLA-DQA1 rs1071630, case-control P = 4.9 x 10(-14), OR = 0.43, 95% CI = 0.35-0.54). 20617178 2010