rs5743618, TLR1

N. diseases: 25
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Asthma
CUI: C0004096
Disease: Asthma
0.720 GeneticVariation GWASCAT Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. 31036433 2019
Asthma
CUI: C0004096
Disease: Asthma
0.720 GeneticVariation GWASCAT Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. 30929738 2019
Asthma
CUI: C0004096
Disease: Asthma
0.720 GeneticVariation BEFREE We evaluated the association of TLR1 rs5743618 and TLR10 rs4129009 polymorphisms with asthma and asthma medication in 125 children aged 11-13 years. 28692144 2018
Asthma
CUI: C0004096
Disease: Asthma
0.720 GeneticVariation GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016
Asthma
CUI: C0004096
Disease: Asthma
0.720 GeneticVariation BEFREE In this study, we demonstrated that TLR1 rs5743618 was associated with asthma and atopic eczema during the first 6 years of life after early bronchiolitis. 24445834 2014
Eczema
CUI: C0013595
Disease: Eczema
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
Childhood asthma
CUI: C0264408
Disease: Childhood asthma
0.700 GeneticVariation GWASCAT Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. 31036433 2019
Respiratory Tract Diseases
CUI: C0035242
Disease: Respiratory Tract Diseases
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
Childhood asthma
CUI: C0264408
Disease: Childhood asthma
0.700 GeneticVariation GWASCAT Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. 30929738 2019
Allergic rhinitis (disorder)
CUI: C2607914
Disease: Allergic rhinitis (disorder)
0.700 GeneticVariation GWASCAT Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. 30013184 2018
Allergic Reaction
CUI: C1527304
Disease: Allergic Reaction
0.700 GeneticVariation GWASCAT Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. 29083406 2017
Tuberculosis
CUI: C0041296
Disease: Tuberculosis
0.040 GeneticVariation BEFREE Stratification of the TB patients according to their bacillary load showed that the genotype 1805TT <i>TLR1</i> (rs5743618) was prevalent among paucibacillary patients [odds ratio (OR) = 0.38; 95% confidence interval (CI) = 0.19-0.76; <i>p</i> = 0.009] while the genotype 1805TG was common among multibacillary patients (OR = 3.72; CI = 1.65-8.4; <i>p</i> = 0.004). 29988507 2018
Tuberculosis, Pulmonary
CUI: C0041327
Disease: Tuberculosis, Pulmonary
0.040 GeneticVariation BEFREE Our findings revealed that TLR1 rs5743551 and rs5743618 polymorphisms affected the risk of PTB in an Iranian population sample. 27998389 2016
Tuberculosis
CUI: C0041296
Disease: Tuberculosis
0.040 GeneticVariation BEFREE Significant differences of the allelic and genotypic distributions of rs5743618 in TLR1 gene were observed between TB group and control group and, G allele of rs5743618 was associated with increased risk for TB (OR: 2.40, 95%CI: 1.41-4.07, P = 0.0009). 25544311 2015
Tuberculosis
CUI: C0041296
Disease: Tuberculosis
0.040 GeneticVariation BEFREE Toll-like Receptor 1 743 A>G, 1805 T>G & Toll-like Receptor 6 745 C>T gene polymorphism and tuberculosis: a case control study of north Indian population from Agra (India). 24984237 2014
Tuberculosis
CUI: C0041296
Disease: Tuberculosis
0.040 GeneticVariation BEFREE TLR1 G1805T is associated with increased TB in Africans and American Hispanics. 23691034 2013
Tuberculosis, Pulmonary
CUI: C0041327
Disease: Tuberculosis, Pulmonary
0.040 GeneticVariation BEFREE T1805G, a functional TLR1 single nucleotide polymorphism (SNP), has been associated with susceptibility to pulmonary tuberculosis (PTB), but contradictory results among different populations have been reported. 23575331 2013
Tuberculosis, Pulmonary
CUI: C0041327
Disease: Tuberculosis, Pulmonary
0.040 GeneticVariation BEFREE The aim of this study was to investigate whether the functional genetic variations at position 1805 G/T in TLR1, 2258 A/G in TLR2, -857 C/T, and -863 A/C in tumor necrosis factor-α (TNF-α), as well as -819 C/T in interleukin-10 (IL-10) confer susceptibility to pulmonary tuberculosis (PTB). 20650298 2010
Tuberculosis, Pulmonary
CUI: C0041327
Disease: Tuberculosis, Pulmonary
0.040 GeneticVariation BEFREE In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G/A (Arg753Gln), TLR-4 896A/G (Asp299Gly), TLR-4 1196C/T (Thr399Ile), TLR-6 745C/T (Ser249Pro), TIRAP 975C/T (Ser180Leu) genes and TLR-9 promoter region polymorphisms at positions -1237C/T and -1486C/T are associated with susceptibility or resistance to pulmonary tuberculosis (PTB). 20797905 2010
Leprosy
CUI: C0023343
Disease: Leprosy
0.020 GeneticVariation BEFREE Conflicting findings about the association between leprosy and TLR1 variants N248S and I602S have been reported. 23547143 2013
Leprosy
CUI: C0023343
Disease: Leprosy
0.020 GeneticVariation BEFREE We have conducted an association analysis of more than 1,500 individuals from different case-control and family studies, and observed consistent associations between genetic variants in both TLR1 and the HLA-DRB1/DQA1 regions with susceptibility to leprosy (TLR1 I602S, case-control P = 5.7 x 10(-8), OR = 0.31, 95% CI = 0.20-0.48, and HLA-DQA1 rs1071630, case-control P = 4.9 x 10(-14), OR = 0.43, 95% CI = 0.35-0.54). 20617178 2010
Lower respiratory tract infection
CUI: C0149725
Disease: Lower respiratory tract infection
0.010 GeneticVariation BEFREE Our findings reveal that single-nucleotide polymorphisms within toll-interleukin 1 receptor domain-containing adaptor protein (<i>TIRAP</i>) alone or in combination with TLR1 N248S, TLR1 I602S, or TLR6 S249P polymorphisms contributes to various degree of susceptibility to recurrent pneumococcal LRTI in children by modulating the inflammatory response. 30131804 2018
Complicated malaria
CUI: C2747816
Disease: Complicated malaria
0.010 GeneticVariation BEFREE Variants in TLR1 (I602S) and TLR6 (P249S) were genotyped by PCR-RFLP methods, and TLR2 (I/D) was genotyped by PCR in 200 samples each from uncomplicated malaria (UM) and severe malaria (SM). 26621243 2016
Malignant Neoplasms
CUI: C0006826
Disease: Malignant Neoplasms
0.010 GeneticVariation BEFREE Our data suggest that TLR1 rs5743618 could serve as a predictor of clinical response to FOLFIRI plus bevacizumab in patients with mCRC.Mol Cancer Ther; 15(7); 1740-5.©2016 AACR. 27196764 2016
Secondary malignant neoplasm of colon and/or rectum
0.010 GeneticVariation BEFREE Our data suggest that TLR1 rs5743618 could serve as a predictor of clinical response to FOLFIRI plus bevacizumab in patients with mCRC. 27196764 2016