Asthma
|
|
0.720 |
GeneticVariation
|
GWASCAT |
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
|
31036433 |
2019 |
Asthma
|
|
0.720 |
GeneticVariation
|
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
Asthma
|
|
0.720 |
GeneticVariation
|
BEFREE |
We evaluated the association of TLR1 rs5743618 and TLR10 rs4129009 polymorphisms with asthma and asthma medication in 125 children aged 11-13 years.
|
28692144 |
2018 |
Asthma
|
|
0.720 |
GeneticVariation
|
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
Asthma
|
|
0.720 |
GeneticVariation
|
BEFREE |
In this study, we demonstrated that TLR1 rs5743618 was associated with asthma and atopic eczema during the first 6 years of life after early bronchiolitis.
|
24445834 |
2014 |
Eczema
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Childhood asthma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
|
31036433 |
2019 |
Respiratory Tract Diseases
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Childhood asthma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
Allergic rhinitis (disorder)
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
|
30013184 |
2018 |
Allergic Reaction
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.
|
29083406 |
2017 |
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Stratification of the TB patients according to their bacillary load showed that the genotype 1805TT <i>TLR1</i> (rs5743618) was prevalent among paucibacillary patients [odds ratio (OR) = 0.38; 95% confidence interval (CI) = 0.19-0.76; <i>p</i> = 0.009] while the genotype 1805TG was common among multibacillary patients (OR = 3.72; CI = 1.65-8.4; <i>p</i> = 0.004).
|
29988507 |
2018 |
Tuberculosis, Pulmonary
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our findings revealed that TLR1 rs5743551 and rs5743618 polymorphisms affected the risk of PTB in an Iranian population sample.
|
27998389 |
2016 |
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Significant differences of the allelic and genotypic distributions of rs5743618 in TLR1 gene were observed between TB group and control group and, G allele of rs5743618 was associated with increased risk for TB (OR: 2.40, 95%CI: 1.41-4.07, P = 0.0009).
|
25544311 |
2015 |
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Toll-like Receptor 1 743 A>G, 1805 T>G & Toll-like Receptor 6 745 C>T gene polymorphism and tuberculosis: a case control study of north Indian population from Agra (India).
|
24984237 |
2014 |
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
TLR1 G1805T is associated with increased TB in Africans and American Hispanics.
|
23691034 |
2013 |
Tuberculosis, Pulmonary
|
|
0.040 |
GeneticVariation
|
BEFREE |
T1805G, a functional TLR1 single nucleotide polymorphism (SNP), has been associated with susceptibility to pulmonary tuberculosis (PTB), but contradictory results among different populations have been reported.
|
23575331 |
2013 |
Tuberculosis, Pulmonary
|
|
0.040 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate whether the functional genetic variations at position 1805 G/T in TLR1, 2258 A/G in TLR2, -857 C/T, and -863 A/C in tumor necrosis factor-α (TNF-α), as well as -819 C/T in interleukin-10 (IL-10) confer susceptibility to pulmonary tuberculosis (PTB).
|
20650298 |
2010 |
Tuberculosis, Pulmonary
|
|
0.040 |
GeneticVariation
|
BEFREE |
In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G/A (Arg753Gln), TLR-4 896A/G (Asp299Gly), TLR-4 1196C/T (Thr399Ile), TLR-6 745C/T (Ser249Pro), TIRAP 975C/T (Ser180Leu) genes and TLR-9 promoter region polymorphisms at positions -1237C/T and -1486C/T are associated with susceptibility or resistance to pulmonary tuberculosis (PTB).
|
20797905 |
2010 |
Leprosy
|
|
0.020 |
GeneticVariation
|
BEFREE |
Conflicting findings about the association between leprosy and TLR1 variants N248S and I602S have been reported.
|
23547143 |
2013 |
Leprosy
|
|
0.020 |
GeneticVariation
|
BEFREE |
We have conducted an association analysis of more than 1,500 individuals from different case-control and family studies, and observed consistent associations between genetic variants in both TLR1 and the HLA-DRB1/DQA1 regions with susceptibility to leprosy (TLR1 I602S, case-control P = 5.7 x 10(-8), OR = 0.31, 95% CI = 0.20-0.48, and HLA-DQA1 rs1071630, case-control P = 4.9 x 10(-14), OR = 0.43, 95% CI = 0.35-0.54).
|
20617178 |
2010 |
Lower respiratory tract infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings reveal that single-nucleotide polymorphisms within toll-interleukin 1 receptor domain-containing adaptor protein (<i>TIRAP</i>) alone or in combination with TLR1 N248S, TLR1 I602S, or TLR6 S249P polymorphisms contributes to various degree of susceptibility to recurrent pneumococcal LRTI in children by modulating the inflammatory response.
|
30131804 |
2018 |
Complicated malaria
|
|
0.010 |
GeneticVariation
|
BEFREE |
Variants in TLR1 (I602S) and TLR6 (P249S) were genotyped by PCR-RFLP methods, and TLR2 (I/D) was genotyped by PCR in 200 samples each from uncomplicated malaria (UM) and severe malaria (SM).
|
26621243 |
2016 |
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data suggest that TLR1 rs5743618 could serve as a predictor of clinical response to FOLFIRI plus bevacizumab in patients with mCRC.Mol Cancer Ther; 15(7); 1740-5.©2016 AACR.
|
27196764 |
2016 |
Secondary malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data suggest that TLR1 rs5743618 could serve as a predictor of clinical response to FOLFIRI plus bevacizumab in patients with mCRC.
|
27196764 |
2016 |