|
Caffeine related disorders
|
|
0.070 |
GeneticVariation
|
BEFREE |
This study aimed to examine whether functional single nucleotide polymorphisms (SNPs) in 1976T > C (ADORA2A; rs5751876) and -163C > A (CYP1A2; rs762551) influence the effect of caffeine on the postprandial glucose (GLU) response to a carbohydrate meal.
|
31324842 |
2019 |
|
Caffeine related disorders
|
|
0.070 |
GeneticVariation
|
BEFREE |
ADORA2A has been shown to be responsible for the wakefulness-promoting effect of caffeine and the 1976T>C genotype (SNP rs5751876, formerly 1083T>C) to contribute to individual sensitivity to caffeine effects on sleep.
|
31817803 |
2019 |
|
Caffeine related disorders
|
|
0.070 |
GeneticVariation
|
BEFREE |
The association between caffeine consumption and objective sleep variables is dependent on ADORA2A c.1083T>C genotypes.
|
28215251 |
2017 |
|
Caffeine related disorders
|
|
0.070 |
GeneticVariation
|
BEFREE |
At the 150 mg dose of caffeine, we found a significant association between caffeine-induced anxiety (Visual Analog Scales, VAS) and ADORA2A rs5751876 (1976C/T), rs2298383 (intron 1a) and rs4822492 (3'-flank), and DRD2 rs1110976 (intron 6).
|
18305461 |
2008 |
|
Caffeine related disorders
|
|
0.070 |
GeneticVariation
|
BEFREE |
We collected information on lifetime coffee drinking and we studied two genes: ADORA2A, which encodes the major receptor activity of caffeine in the brain (variants rs5751876 and rs3032740), and CYP1A2, which encodes the major rate-limiting step of caffeine metabolism (variants rs35694136 and rs762551).
|
18759349 |
2008 |
|
Caffeine related disorders
|
|
0.070 |
GeneticVariation
|
BEFREE |
Here we show in humans that (1) habitual caffeine consumption is associated with reduced sleep quality in self-rated caffeine-sensitive individuals, but not in caffeine-insensitive individuals; (2) the distribution of distinct c.1083T>C genotypes of the adenosine A2A receptor gene (ADORA2A) differs between caffeine-sensitive and -insensitive adults; and (3) the ADORA2A c.1083T>C genotype determines how closely the caffeine-induced changes in brain electrical activity during sleep resemble the alterations observed in patients with insomnia.
|
17329997 |
2007 |
|
Caffeine related disorders
|
|
0.070 |
GeneticVariation
|
BEFREE |
We examined whether genetic variability in caffeine metabolism [cytochrome P450 1A2 (CYP1A2) -163A-->C] or the main target of caffeine action in the nervous system [adenosine A(2A) receptor (ADORA2A) 1083C-->T] is associated with habitual caffeine consumption.
|
17616786 |
2007 |
|
Anxiety Disorders
|
|
0.050 |
GeneticVariation
|
BEFREE |
Here, it was investigated whether the adenosine 2 A receptor gene (ADORA2A) 1976T/C (rs5751876) variant - previously associated with anxiety disorders and anxiety-related phenotypes as well as general attentional efficiency -was involved in the regulation of this network.
|
27262510 |
2016 |
|
Anxiety Disorders
|
|
0.050 |
GeneticVariation
|
BEFREE |
The complex pathogenesis of anxiety and panic disorder in particular has been suggested to be influenced by genetic factors such as the adenosine A2A receptor gene (ADORA2A) 1976T>C polymorphism (rs5751876) as well as neuropsychological factors such as early information processing deficits.
|
22940476 |
2013 |
|
Anxiety Disorders
|
|
0.050 |
GeneticVariation
|
BEFREE |
Results showed greater susceptibility to caffeine-induced anxiety, but not lower habitual caffeine intake (indeed coffee intake was higher), in the rs5751876 TT genotype group, and a reduced anxiety response in MH vs NL participants irrespective of genotype.
|
20520601 |
2010 |
|
Anxiety Disorders
|
|
0.050 |
GeneticVariation
|
BEFREE |
A variant within the corresponding ADORA2A gene (rs5751876) increased the risk for panic disorder (PD), for elevated anxiety during challenge tests in healthy probands and for anxiety-related arousal in blood-injury phobia.
|
20334879 |
2010 |
|
Anxiety Disorders
|
|
0.050 |
GeneticVariation
|
BEFREE |
At the 150 mg dose of caffeine, we found a significant association between caffeine-induced anxiety (Visual Analog Scales, VAS) and ADORA2A rs5751876 (1976C/T), rs2298383 (intron 1a) and rs4822492 (3'-flank), and DRD2 rs1110976 (intron 6).
|
18305461 |
2008 |
|
Anxiety
|
|
0.040 |
GeneticVariation
|
BEFREE |
The complex pathogenesis of anxiety and panic disorder in particular has been suggested to be influenced by genetic factors such as the adenosine A2A receptor gene (ADORA2A) 1976T>C polymorphism (rs5751876) as well as neuropsychological factors such as early information processing deficits.
|
22940476 |
2013 |
|
Anxiety
|
|
0.040 |
GeneticVariation
|
BEFREE |
A variant within the corresponding ADORA2A gene (rs5751876) increased the risk for panic disorder (PD), for elevated anxiety during challenge tests in healthy probands and for anxiety-related arousal in blood-injury phobia.
|
20334879 |
2010 |
|
Anxiety
|
|
0.040 |
GeneticVariation
|
BEFREE |
Results showed greater susceptibility to caffeine-induced anxiety, but not lower habitual caffeine intake (indeed coffee intake was higher), in the rs5751876 TT genotype group, and a reduced anxiety response in MH vs NL participants irrespective of genotype.
|
20520601 |
2010 |
|
Anxiety
|
|
0.040 |
GeneticVariation
|
BEFREE |
At the 150 mg dose of caffeine, we found a significant association between caffeine-induced anxiety (Visual Analog Scales, VAS) and ADORA2A rs5751876 (1976C/T), rs2298383 (intron 1a) and rs4822492 (3'-flank), and DRD2 rs1110976 (intron 6).
|
18305461 |
2008 |
|
Sleeplessness
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs5751876 T allele was associated with a decreased risk of sleep complaints (Ora = 0.7 [0.3-0.9]) and insomnia (Ora = 0.5 [0.3-0.9]).
|
31817803 |
2019 |
|
Panic Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
The complex pathogenesis of anxiety and panic disorder in particular has been suggested to be influenced by genetic factors such as the adenosine A2A receptor gene (ADORA2A) 1976T>C polymorphism (rs5751876) as well as neuropsychological factors such as early information processing deficits.
|
22940476 |
2013 |
|
Panic Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
We were indeed able to replicate rs5751876 as risk factor for PD, particularly PD with agoraphobia.
|
20334879 |
2010 |
|
Sleeplessness
|
|
0.020 |
GeneticVariation
|
BEFREE |
Here we show in humans that (1) habitual caffeine consumption is associated with reduced sleep quality in self-rated caffeine-sensitive individuals, but not in caffeine-insensitive individuals; (2) the distribution of distinct c.1083T>C genotypes of the adenosine A2A receptor gene (ADORA2A) differs between caffeine-sensitive and -insensitive adults; and (3) the ADORA2A c.1083T>C genotype determines how closely the caffeine-induced changes in brain electrical activity during sleep resemble the alterations observed in patients with insomnia.
|
17329997 |
2007 |
|
Familial neurocardiogenic syncope
|
|
0.010 |
GeneticVariation
|
BEFREE |
Adenosine A(2A) receptor 1083 T > C polymorphism is not associated with the positivity of HUT and its proposed role in predisposition to VVS was not confirmed.
|
26710963 |
2016 |
|
Akathisia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found an association between ADORA1 rs3766566 and psychopathological symptoms (p = 0.006), in particular, with positive psychopathological symptoms (p = 0.010) and general psychopathological symptoms (p = 0.023), between ADORA2A rs2298383 and general psychopathological symptoms (p = 0.046), and between ADORA2A rs5751876 and akathisia (p = 0.015).
|
27195966 |
2016 |
|
Syncope
|
|
0.010 |
GeneticVariation
|
BEFREE |
One thousand and eighty-three T > C single nucleotide polymorphism in the adenosine A(2A) receptor gene (rs5751876) was evaluated in 347 patients with syncope and in 85 subjects without history of syncope (54 men, mean age 41.7 ± 16.3).
|
26710963 |
2016 |
|
Gilles de la Tourette syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
The minor allele T frequency of rs5751876 was lower in GTS patients with </span>co-morbid attention deficit hyperactivity disorder (p = 0.022), and TT+TC genotypes were less frequent in the non-OCD anxiety disorder group (p = 0.045).
|
26317759 |
2015 |
|
Malaria
|
|
0.010 |
GeneticVariation
|
BEFREE |
Single-locus analysis showed significant association of 2 SNPs; rs5751876 (OR=3.2(2.0-5.2); p=0.0006) of ADORA2A and rs2230345 (OR=0.3(0.2-0.5); p=0.0006) of GRK5 with malaria.
|
26066465 |
2015 |