ovarian neoplasm
|
|
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.
|
1978757 |
1990 |
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
A germ line mutation in exon 5 of the p53 gene in an extended cancer family.
|
1933902 |
1991 |
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome.
|
2259385 |
1991 |
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia.
|
1737852 |
1992 |
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms.
|
1565144 |
1992 |
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome.
|
7887414 |
1995 |
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
An extended Li-Fraumeni kindred with gastric carcinoma and a codon 175 mutation in TP53.
|
8825920 |
1995 |
Neoplastic Syndromes, Hereditary
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Dominant-negative p53 mutations selected in yeast hit cancer hot spots.
|
8633021 |
1996 |
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
A germline missense mutation R337C in exon 10 of the human p53 gene.
|
9452042 |
1998 |
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Hereditary TP53 codon 292 and somatic P16INK4A codon 94 mutations in a Li-Fraumeni syndrome family.
|
10484981 |
1999 |
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
One of the earliest genetic aberrations is a missense mutation of codon 179 (His179Asn) in the tumor suppressor gene TP53 leading to outgrowth of a cell type expressing only the mutant form of TP53.
|
10616528 |
2000 |
Li-Fraumeni Syndrome
|
|
0.800 |
CausalMutation
|
CLINVAR |
Tumour p53 mutations exhibit promoter selective dominance over wild type p53.
|
11896595 |
2002 |
Li-Fraumeni Syndrome
|
|
0.800 |
CausalMutation
|
CLINVAR |
A novel p53 mutant retained functional activity in lung carcinomas.
|
12509279 |
2002 |
LI-FRAUMENI SYNDROME 1
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Tumour p53 mutations exhibit promoter selective dominance over wild type p53.
|
11896595 |
2002 |
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
American Society of Clinical Oncology policy statement update: genetic testing for cancer susceptibility.
|
12692171 |
2003 |
Li-Fraumeni Syndrome
|
|
0.800 |
CausalMutation
|
CLINVAR |
Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis.
|
12826609 |
2003 |
Li-Fraumeni Syndrome
|
|
0.800 |
CausalMutation
|
CLINVAR |
p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis.
|
12726864 |
2003 |
LI-FRAUMENI SYNDROME 1
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis.
|
12826609 |
2003 |
LI-FRAUMENI SYNDROME 1
|
|
0.700 |
GeneticVariation
|
CLINVAR |
p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis.
|
12726864 |
2003 |
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Genetic cancer risk assessment and counseling: recommendations of the national society of genetic counselors.
|
15604628 |
2004 |
Li-Fraumeni Syndrome
|
|
0.800 |
CausalMutation
|
CLINVAR |
[Germline tp53 neomutation in a patient with Li-Fraumeni syndrome and pancreatic adenocarcinoma].
|
16633321 |
2006 |
LI-FRAUMENI SYNDROME 1
|
|
0.700 |
GeneticVariation
|
CLINVAR |
[Germline tp53 neomutation in a patient with Li-Fraumeni syndrome and pancreatic adenocarcinoma].
|
16633321 |
2006 |
Li-Fraumeni Syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography.
|
17392385 |
2007 |
Li-Fraumeni Syndrome
|
|
0.800 |
CausalMutation
|
CLINVAR |
The over-expression of p53 H179Y residue mutation causes the increase of cyclin A1 and Cdk4 expression in HELF cells.
|
17530187 |
2007 |