|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Leu33/Pro polymorphism (PlA1/PlA2) of the glycoprotein IIIa (GPIIIa) receptor is not related to myocardial infarction in the ECTIM Study. Etude Cas-Temoins de l'Infarctus du Myocarde.
|
9241754 |
1997 |
|
Coronary Thrombosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The PlA polymorphism (Leu33Pro) of the platelet glycoprotein (GP) IIIa gene has been suggested to play an important role in coronary thrombosis.
|
15166949 |
2004 |
|
ovarian neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
Integrin beta(3) Leu33Pro homozygotes have an increased risk of ovarian cancer.
|
16322334 |
2005 |
|
Malignant neoplasm of ovary
|
|
0.030 |
GeneticVariation
|
BEFREE |
Integrin beta(3) Leu33Pro homozygotes have an increased risk of ovarian cancer.
|
16322334 |
2005 |
|
Carcinoma, Ovarian Epithelial
|
|
0.030 |
GeneticVariation
|
BEFREE |
Integrin beta(3) Leu33Pro homozygotes have an increased risk of ovarian cancer.
|
16322334 |
2005 |
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
We previously demonstrated that integrin beta(3) Leu33Pro homozygotes have an increased risk of cancer, possibly most pronounced for ovarian cancer.
|
16322334 |
2005 |
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Leu33Pro heterozygotes, homozygotes and heterozygotes+homozygotes vs noncarriers had odds ratios for breast cancer of 1.0 (95% confidence interval: 0.8-1.1), 0.8 (0.5-1.2) and 1.0 (0.8-1.1), respectively.
|
15970922 |
2005 |
|
Malignant neoplasm of breast
|
|
0.020 |
GeneticVariation
|
BEFREE |
Leu33Pro heterozygotes, homozygotes and heterozygotes+homozygotes vs noncarriers had odds ratios for breast cancer of 1.0 (95% confidence interval: 0.8-1.1), 0.8 (0.5-1.2) and 1.0 (0.8-1.1), respectively.
|
15970922 |
2005 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
We previously demonstrated that integrin beta(3) Leu33Pro homozygotes have an increased risk of cancer, possibly most pronounced for ovarian cancer.
|
16322334 |
2005 |
|
Cardiovascular Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results suggest that variation in ITGB3 in addition to Leu33Pro could contribute to susceptibility to CVD and serotonin in a sex-specific manner.
|
15834589 |
2005 |
|
Factor V Leiden mutation
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotypes of factor V R506Q (factor V Leiden), prothrombin 20210G>A, fibrinogen beta -455G> A, factor XII (FXII) 46C>T, and ITGA2 807C>T (platelet glycoprotein Ia [GPIa] 807C>T) and ITGB3 L59P (platelet GPIIIa PlA1/PlA2) polymorphisms.
|
16157382 |
2005 |
|
Malignant neoplasm of breast
|
|
0.020 |
GeneticVariation
|
BEFREE |
The ITGB3 176T>C polymorphisms was not associated with breast cancer susceptibility.
|
16317580 |
2006 |
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The ITGB3 176T>C polymorphisms was not associated with breast cancer susceptibility.
|
16317580 |
2006 |
|
Malignant neoplasm of ovary
|
|
0.030 |
GeneticVariation
|
BEFREE |
Integrin beta3 Leu33Pro polymorphism increases BRCA1-associated ovarian cancer risk.
|
17220212 |
2007 |
|
ovarian neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
Integrin beta3 Leu33Pro polymorphism increases BRCA1-associated ovarian cancer risk.
|
17220212 |
2007 |
|
Carcinoma, Ovarian Epithelial
|
|
0.030 |
GeneticVariation
|
BEFREE |
Integrin beta3 Leu33Pro polymorphism increases BRCA1-associated ovarian cancer risk.
|
17220212 |
2007 |
|
Exercise-induced angina
|
|
0.010 |
GeneticVariation
|
BEFREE |
An SNP in ITGB3 (Leu59Pro, rs5918) was slightly, but not significantly (P = .083), more common among patients with acute MI (minor allele frequency 14.5%) than among patients with stable exertional angina (minor allele frequency 12.0%).
|
18035074 |
2007 |
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The ITGA2 1648G> and the ITGB3 176T>C polymorphism were not associated with colorectal cancer.
|
18836731 |
2009 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation
|
BEFREE |
The ITGA2 1648G> and the ITGB3 176T>C polymorphism were not associated with colorectal cancer.
|
18836731 |
2009 |
|
Carcinoma, Ovarian Epithelial
|
|
0.030 |
GeneticVariation
|
BEFREE |
The ITGB3 Leu33Pro polymorphism does not modify breast or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers.
|
19876733 |
2010 |
|
ovarian neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
The ITGB3 Leu33Pro polymorphism does not modify breast or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers.
|
19876733 |
2010 |
|
Malignant neoplasm of ovary
|
|
0.030 |
GeneticVariation
|
BEFREE |
The ITGB3 Leu33Pro polymorphism does not modify breast or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers.
|
19876733 |
2010 |
|
Cerebrovascular accident
|
|
0.020 |
GeneticVariation
|
BEFREE |
This is the first study to demonstrate associations between stroke functional outcome and 2 COX-2 variants (rs20417 and rs5275) and a GPIIIa variant (rs5918).
|
20472470 |
2011 |
|
Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined the association of a single nucleotide polymorphism (SNP) in the GPIIIa platelet glycoprotein (Leu33Pro) with carotid artery plaque morphology and with expression of platelet markers using data from the Atherosclerosis Risk in Communities (ARIC) Carotid MRI study.
|
21353223 |
2011 |
|
Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined the association of a single nucleotide polymorphism (SNP) in the GPIIIa platelet glycoprotein (Leu33Pro) with carotid artery plaque morphology and with expression of platelet markers using data from the Atherosclerosis Risk in Communities (ARIC) Carotid MRI study.
|
21353223 |
2011 |