|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A sample of AD subjects (N = 341) was genotyped for the BDNF polymorphisms: Val66Met, C270T, and G-712A.
|
19542613 |
2009 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism in the human BDNF gene (Val66Met) affects memory, and influences Alzheimer's disease and depression vulnerability in a sex-specific manner.
|
20097294 |
2010 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A total of 1,081 adults without dementia (375 healthy subjects and 706 individuals with mild cognitive impairment) were recruited from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to test the influence of BDNF Val66Met polymorphism on cognitive impairment, brain structure atrophy, and change in the levels of CSF biomarkers.
|
30775992 |
2019 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
After stratification by sex, we found a significant allelic association between Val66Met and AD in women (P = 0.017), but not in men.
|
19504537 |
2010 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although Val66Met polymorphisms were not associated with the cross-sectional diagnoses of MCI or AD, the presence of Met-BDNF allele was associated with a higher risk of disease-progression in patients with MCI (OR=3.0 CI(95%) [1.2-7.8], P=0.02).
|
20491609 |
2010 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among 200 outpatients with dementia and MCI, 146 outpatients with mild AD or A-MCI were recruited and divided into two genotypic groups, valine homozygosity (Val/Val) and methionine (Met) carriers, based on the representative BDNF functional polymorphism Val66Met.
|
22699449 |
2012 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association analysis of brain-derived neurotrophic factor (BDNF) gene 196 A/G polymorphism with Alzheimer's disease (AD) in mainland Chinese.
|
16054753 |
2005 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between BDNF Val66Met polymorphism and Alzheimer disease, dementia with Lewy bodies, and Pick disease.
|
19812463 |
2010 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met in preclinical Alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF.
|
28720165 |
2017 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has previously been implicated in Alzheimer's disease (AD)-related cognitive impairment.
|
23769397 |
2013 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Comparison of 487 Japanese AD subjects with 471 cognitively normal elderly controls showed higher frequencies of the G allele (60.5 vs. 55.5%, p = 0.028) and of both the GG and GA genotypes (85.8 vs. 79.8%, p = 0.025) of the G196A polymorphism in AD subjects than in controls and higher frequency of the T allele of the C270T polymorphism in AD subjects who were negative for apolipotrotein E4 (2.0 vs. 4.4%, p = 0.035) or positive for AD family history (2.8 vs. 7.1%, p = 0.046).
|
15375678 |
2005 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Cross-sectional genetic association studies have reported equivocal results on the relationship between the brain-derived neurotrophic factor (BDNF) Val66Met and risk of Alzheimer's disease (AD).
|
24475133 |
2014 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Dose-dependent genotype effects of BDNF Val66Met polymorphism on default mode network in early stage Alzheimer's disease.
|
27494844 |
2016 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease.
|
20613678 |
2010 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic analysis revealed rs2030324 and rs6265 were associated with aMCI and rs6265 was associated with AD conversion.
|
28387675 |
2017 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here we review the role and relevance of the BDNF Val66Met polymorphism in neurodegenerative diseases, with particular emphasis on glaucoma, multiple sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD).
|
29896439 |
2018 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, one specific set of genes, the brain derived neurotrophic factor (BDNF), specifically the Val66Met polymorphism, may play a crucial role in AD-related depression.
|
27335045 |
2017 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, we observed a clear female-specific risk trend for the effect of rs6265</span> on AD endophenotypes.
|
28202203 |
2017 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, val66met polymorphism and BDNF serum level between the three groups and genotype did not significantly affect the serum BDNF level or age, Mini-Mental State Examination score in AD and aMCI.
|
23270505 |
2013 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, the plasma BDNF level did not differ significantly among the three BDNF Val66Met genotypic groups or between patients with A-MCI and those with AD.
|
24253237 |
2014 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Nevertheless, after adjusting for age and APOE ε4 status, Val66Met was not associated with AD in females (OR, 1.02; 95% CI, 0.94-1.11; P = .57).
|
28984138 |
2018 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
One hundred and sixty-nine outpatients with AD or amnestic mild cognitive impairment (A-MCI) were recruited to the study and divided into three genotypic groups for each representative BDNF functional polymorphism as follows: (i) Val66Met (G196A): G/G (n = 45), G/A (n = 104), and A/A (n = 20); and (ii) C270T: C/C (n = 160), C/T (n = 9), and T/T (n = 0).
|
21951954 |
2011 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our negative findings suggest that it is unlikely that the BDNF Val66Met polymorphism plays a major role in the pathogenesis of AD in the Chinese population and do not support previous findings that homozygosity for the 66Val allele confers an increased risk for AD.
|
14730194 |
2004 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Prefrontal cortex BDNF gene expression is associated with aging, rs6265 carrier status, and AD neuropathology in a variant-specific manner that seems to be independent of DNA methylation influences.
|
31127785 |
2019 |
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent association studies have suggested that the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene could play a role in the development of AD.
|
18786162 |
2009 |