rs6265, BDNF;BDNF-AS

N. diseases: 272
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression. 19335934 2009
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE A meta-analysis of studies was conducted to compare the frequency of the BDNF Val66Met variant between cases with geriatric depression and age-matched controls. 22610920 2012
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression. 17941097 2008
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. 19153574 2009
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE The combination of disadvantageous allelic expression of rs6295 and rs6265 may result in a 5-HT<sub>1A</sub> receptor profile comparable to affective disorders as increased 5-HT<sub>1A</sub> receptor binding is a well published phenotype of depression. 30664620 2019
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE The analysis revealed a strong association between the rs6265 genotype distribution and AD-D (p=0.005 after Bonferroni correction), and the A allele of rs6265 was significantly overrepresented in AD-D patients compared to AD without depression (AD-nD) patients (p=0.001 after Bonferroni correction). 21880305 2011
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE We investigated the effect of brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism on the severity of depressive and anxiety symptoms in never-smokers, former smokers, non-dependent, and nicotine-dependent smokers with a current diagnosis of depression and/or anxiety. 25618300 2015
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE To examine the effect of seasonality and rs6265 genotype on depression outcome and brain-derived neurotrophic factor (BDNF) level with dermatitis patients from onset through remission. 27409526 2017
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE The results suggest that interactions may occur after stresses among BDNF Val66Met, gender and time course to influence dep</span>ression. 28527683 2017
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE These findings are in accordance with the previously uncovered pathway between BDNF Val66Met, resting state EEG alpha power, and depression severity. 23733090 2013
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE We found evidence that supported the hypothesis that BDNF Val66Met polymorphism moderated the relationship between stress and depression, despite the fact that many included individual studies did not show this effect. 29102837 2018
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV. 23157339 2013
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value < 0.025). 20515362 2010
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE Imaging genetics studies have investigated the influence of the serotonin transporter-linked polymorphic region (5HTTLPR) and brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on the hippocampus in healthy individuals and patients with depression (MDD). 21692988 2011
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE In 732 Korean community residents ages 65+, diagnosis of depression (Geriatric Mental State Schedule), information on SLEs, and genotypes for 5-HTTLPR and BDNF val66met were ascertained. 17482146 2007
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE The BDNF:rs6265 Met-allele was overrepresented in depression for women with problems during their childhood. 20226536 2010
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE BDNF Val66Met polymorphism and stressful life events in melancholic childhood-onset depression. 26462036 2015
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE The polymorphism BDNF val66met of the brain derived neurotrophic factor (BDNF) is common, may increase the risk for depression, and affects BDNF secretion, critical for neuronal survival, plasticity, neurogenesis, and synaptic connectivity. 20346518 2010
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE The current study examined the effects of val66met, 5-HTTLPR, and family environment quality on youth depressive symptoms in adolescence and young adulthood in a longitudinal sample oversampled for maternal depression history. 25347540 2014
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects. 21420735 2011
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression. 30329132 2020
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE The results suggest that the Met allele of BDNF Val66Met significantly moderates the relationship between life stress and depression (P = 0.03). 24433458 2014
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE The BDNF val66met polymorphism may modify the association between stroke and depression. 17222482 2008
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE We investigated the independent and interactive effects of BDNF methylation and val66met polymorphism on late-life depression. 25648279 2015
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE The aims of the present case-control study were to investigate the possible role of BDNF Val66Met, 5-HTTLPR and -1438 G/A polymorphisms in the development of coronary artery disease (CAD) in patients with and without depression. 19885623 2009