|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genotype and allele frequencies for the BDNF gene Val66Met polymorphism did not differ comparing depression groups (total, bipolar disorder or major depression) and control subjects.
|
14673216 |
2003 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Assuming that BDNF may be implicated in the putative common pathophysiology of depression and anxiety, we analyzed the association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (formerly named C270T) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with panic disorder.
|
15913870 |
2005 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that the BDNF Val66Met polymorphism is a relevant risk factor for geriatric depression.
|
16343697 |
2006 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
In 732 Korean community residents ages 65+, diagnosis of depression (Geriatric Mental State Schedule), information on SLEs, and genotypes for 5-HTTLPR and BDNF val66met were ascertained.
|
17482146 |
2007 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Rumination may be an endophenotype in the pathway from the BDNF Val66Met polymorphism to depression.
|
17959306 |
2007 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
I will also review key studies, both human and animal, which have investigated the association of a BDNF single-nucleotide polymorphism (Val66Met) with depression pathogenesis, and detail the number of inconsistencies which also afflict this novel area of BDNF research.
|
17700574 |
2007 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression.
|
17911362 |
2007 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (Val66Met), which has been shown to have functional and behavioral effects, was genotyped in 284 depressed participants and 331 controls, showing association with depression (P=0.005).
|
17632285 |
2007 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression.
|
17941097 |
2008 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF val66met polymorphism may modify the association between stroke and depression.
|
17222482 |
2008 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression.
|
18263664 |
2008 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
According to this rationale, we investigated the role of two functional polymorphisms in the genes coding for the serotonin transporter (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF Val66Met), and rTMS response in a group of 36 drug resistant patients affected by mood disorders. rTMS treatment significantly improved depression symptomatology (p<0.0001) and the response was significantly greater in 5-HTTLPR LL homozygotes compared to S allele carriers (p=0.007) and in BDNF Val/Val homozygotes compared to Met allele carriers (p=0.024).
|
18450378 |
2008 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
5-HTTLPR and BDNF VAL66MET, functional polymorphisms of the serotonin (5-HT) transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene, impact on two distinct, but interacting signaling systems, which have been related to depression and to the modulation of neurogenesis and plasticity of circuitries of emotion processing.
|
18347599 |
2008 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between BDNF Val66Met polymorphism and trait depression is mediated via resting EEG alpha band activity.
|
18721847 |
2008 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analysis of Val66Met in depression obtained an overall summary OR of 1.06 (95% CI: 0.89-1.26, P = 0.537) comparing MM with VV genotypes and an OR of 0.97 (95% CI: 0.89-1.05, P = 0.403) comparing MV with VV genotypes.
|
18205169 |
2008 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression.
|
19335934 |
2009 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety.
|
19153574 |
2009 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aims of the present case-control study were to investigate the possible role of BDNF Val66Met, 5-HTTLPR and -1438 G/A polymorphisms in the development of coronary artery disease (CAD) in patients with and without depression.
|
19885623 |
2009 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The low activity variants of the 5-HTT-linked polymorphic region in the serotonin transporter gene and the Met-allele of a single nucleotide polymorphism (Val66Met) in the gene encoding brain derived neurotrophic factor were independently associated with the presence of stressful life events prior to onset of depression, also when corrected for the effect of age, gender, marital status, personality disorder, neuroticism, and severity of depressive symptoms at the time of interview.
|
19339052 |
2009 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we determined the effects of the BDNF Val66met polymorphism on the five-factor personality dimensions (assessed using the NEO-FFI), trait depression (assessed with the DASS-21) in a cross-sectional cohort of 467 healthy volunteers.
|
18548532 |
2009 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to assess the genetic contribution of BDNF Val66Met functional polymorphism to AD-related depression.
|
18179845 |
2009 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value < 0.025).
|
20515362 |
2010 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF:rs6265 Met-allele was overrepresented in depression for women with problems during their childhood.
|
20226536 |
2010 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphism BDNF val66met of the brain derived neurotrophic factor (BDNF) is common, may increase the risk for depression, and affects BDNF secretion, critical for neuronal survival, plasticity, neurogenesis, and synaptic connectivity.
|
20346518 |
2010 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism in the human BDNF gene (Val66Met) affects memory, and influences Alzheimer's disease and depression vulnerability in a sex-specific manner.
|
20097294 |
2010 |