|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val66Met functional polymorphism and serum protein level of brain-derived neurotrophic factor (BDNF) in acute episode of schizophrenia and depression.
|
29331787 |
2018 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Plasma brain-derived neurotrophic factor (BDNF) concentration and the <i>BDNF</i> Val66Met polymorphism in suicide: a prospective study in patients with depressive disorder.
|
31308724 |
2019 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Rumination may be an endophenotype in the pathway from the BDNF Val66Met polymorphism to depression.
|
17959306 |
2007 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphism BDNF val66met of the brain derived neurotrophic factor (BDNF) is common, may increase the risk for depression, and affects BDNF secretion, critical for neuronal survival, plasticity, neurogenesis, and synaptic connectivity.
|
20346518 |
2010 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to assess the genetic contribution of BDNF Val66Met functional polymorphism to AD-related depression.
|
18179845 |
2009 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The influence of 5-HTTLPR and Val66Met polymorphisms on cortical thickness and volume in limbic and paralimbic regions in depression: a preliminary study.
|
26976307 |
2016 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects.
|
21420735 |
2011 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Modulatory effects of the BDNF Val66Met polymorphism on distinct subregions in the prefrontal cortex in MDD support the neurotrophin model of depression.
|
25745134 |
2015 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The analysis revealed a strong association between the rs6265 genotype distribution and AD-D (p=0.005 after Bonferroni correction), and the A allele of rs6265 was significantly overrepresented in AD-D patients compared to AD without depression (AD-nD) patients (p=0.001 after Bonferroni correction).
|
21880305 |
2011 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Given that BDNF secretion is affected by a common polymorphism (rs6265, Val66Met), which also is associated with depression, we investigated whether this polymorphism modifies the effect of childhood adversity (CA) on local gray matter (GM) volume in depression-relevant brain regions, using data from two large cohorts of healthy subjects.
|
21577214 |
2012 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, one specific set of genes, the brain derived neurotrophic factor (BDNF), specifically the Val66Met polymorphism, may play a crucial role in AD-related depression.
|
27335045 |
2017 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression.
|
17911362 |
2007 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
No differences in whole blood BDNF was seen in relation to the BDNF Val66Met polymorphism and no significant correlations between whole blood BDNF and HAMD-17 or BDI 21 scores were found.
|
23684538 |
2013 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism might be implicated in the pathogenesis of depression in T2DM by decreasing serum BDNF levels in Han Chinese Subjects.
|
23968401 |
2013 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The val66met variant located within the brain-derived neurotrophic factor gene (BDNF) has previously been associated with human neuroticism, a dimension of personality strongly predictive of depressive illness.
|
16043130 |
2005 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value < 0.025).
|
20515362 |
2010 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present findings indicate the gender differences in the effect of Val66Met genotype on the cortisol responses to stress protocol, and extend the evidence for the importance of gender and the role of Val66Met in the modulation of stress reactivity and subsequent depression prevalence.
|
28249185 |
2017 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Assuming that BDNF may be implicated in the putative common pathophysiology of depression and anxiety, we analyzed the association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (formerly named C270T) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with panic disorder.
|
15913870 |
2005 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
According to this rationale, we investigated the role of two functional polymorphisms in the genes coding for the serotonin transporter (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF Val66Met), and rTMS response in a group of 36 drug resistant patients affected by mood disorders. rTMS treatment significantly improved depression symptomatology (p<0.0001) and the response was significantly greater in 5-HTTLPR LL homozygotes compared to S allele carriers (p=0.007) and in BDNF Val/Val homozygotes compared to Met allele carriers (p=0.024).
|
18450378 |
2008 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results indicate that there was a lack of association between severity of depression and BDNF Val66Met polymorphism in Chinese patients with MDD.
|
20016225 |
2010 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The low activity variants of the 5-HTT-linked polymorphic region in the serotonin transporter gene and the Met-allele of a single nucleotide polymorphism (Val66Met) in the gene encoding brain derived neurotrophic factor were independently associated with the presence of stressful life events prior to onset of depression, also when corrected for the effect of age, gender, marital status, personality disorder, neuroticism, and severity of depressive symptoms at the time of interview.
|
19339052 |
2009 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met contributed to the severity of CSI even after adjusting to PTSD, depression and LEC.
|
30904785 |
2019 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Associations between the BDNF val66met polymorphism and both depression status and treatment response were investigated using logistic regression models.
|
26795846 |
2016 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide polymorphism may be associated with clinical and subsyndromal depression, but physical activity improves mood and increases BDNF expression.
|
24745471 |
2014 |