rs6265, BDNF;BDNF-AS

N. diseases: 272
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE 5-HTTLPR and BDNF VAL66MET, functional polymorphisms of the serotonin (5-HT) transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene, impact on two distinct, but interacting signaling systems, which have been related to depression and to the modulation of neurogenesis and plasticity of circuitries of emotion processing. 18347599 2008
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Val66Met functional polymorphism and serum protein level of brain-derived neurotrophic factor (BDNF) in acute episode of schizophrenia and depression. 29331787 2018
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE A functional BDNF polymorphism (BDNF Val66Met) was reported to influence the effects of stressful life events or childhood adversity on depression and suicidal behaviour in various psychopathologies. 20667416 2011
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE A genetic variant (rs6265) of the brain-derived neurotrophic factor (BDNF) impacting on emotion processing is known to increase the risk for depression. 25998702 2015
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE A meta-analysis of studies was conducted to compare the frequency of the BDNF Val66Met variant between cases with geriatric depression and age-matched controls. 22610920 2012
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE A multivariable linear regression model showed that the best predictors of depression were the SF-36 General health (β = -0.209; P = 0.013), Mental health (β = -0.410; P < 0.001) and Social activity (β = -0.195; P = 0.035) scores; physical disability (assessed by the Extended Disability Status Scale score) was directly correlated to depression severity on univariate analysis, but it was not a relevant predictor of depression on multivariate analysis; other variables directly related to the disease (treatment, annual relapsing rate) and the BDNF Val66Met polymorphism were not significantly associated with depression. 26756166 2016
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE A single nucleotide polymorphism in the human BDNF gene (Val66Met) affects memory, and influences Alzheimer's disease and depression vulnerability in a sex-specific manner. 20097294 2010
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE According to this rationale, we investigated the role of two functional polymorphisms in the genes coding for the serotonin transporter (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF Val66Met), and rTMS response in a group of 36 drug resistant patients affected by mood disorders. rTMS treatment significantly improved depression symptomatology (p<0.0001) and the response was significantly greater in 5-HTTLPR LL homozygotes compared to S allele carriers (p=0.007) and in BDNF Val/Val homozygotes compared to Met allele carriers (p=0.024). 18450378 2008
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Additionally, the association between DED and Val66Met may vary by depression status. 26393465 2015
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression. 17911362 2007
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Association between BDNF Val66Met polymorphism and trait depression is mediated via resting EEG alpha band activity. 18721847 2008
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Association of BDNF Val66MET Polymorphism With Parkinson's Disease and Depression and Anxiety Symptoms. 27852165 2017
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Associations between the BDNF val66met polymorphism and both depression status and treatment response were investigated using logistic regression models. 26795846 2016
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Assuming that BDNF may be implicated in the putative common pathophysiology of depression and anxiety, we analyzed the association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (formerly named C270T) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with panic disorder. 15913870 2005
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE BDNF Val66Met genotype and 6-month remission rates in late-life depression. 20195291 2011
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE BDNF Val66Met polymorphism and stressful life events in melancholic childhood-onset depression. 26462036 2015
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Both the functional Val66Met BDNF polymorphism (rs6265) and BDNF levels have been associated with depression. 23303061 2013
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Childhood adversity showed an interaction with the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism, serotonin transporter-linked promoter region (5-HTTLPR), and FK506 binding protein 51 (FKBP5) gene rs1360780 in brain morphologic changes in patients with depression and in a non-clinical population. 29535036 2019
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Discussion The dynamics of serum BDNF levels, but not plasma levels of HVA and MHPG, reflect the response to mirtazapine treatment; the BDNF Val66Met polymorphism in patients with depression is, however, associated with neither a particular response to mirtazapine treatment nor baseline serum BDNF levels. 22883353 2012
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Finally, using functional magnetic resonance imaging, we found that viewing sad faces evoked greater activity in d</span>epression-related areas in healthy control subjects possessing the minor alleles of BDNF-rs6265 and CREB1-rs2253206. 21215389 2011
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Further studies are needed to evaluate the associations between rs6265 and poststroke depression, especially in Caucasians, with large sample size. 29449128 2018
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse. 21996278 2012
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Given that BDNF secretion is affected by a common polymorphism (rs6265, Val66Met), which also is associated with depression, we investigated whether this polymorphism modifies the effect of childhood adversity (CA) on local gray matter (GM) volume in depression-relevant brain regions, using data from two large cohorts of healthy subjects. 21577214 2012
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Here, we determined the effects of the BDNF Val66met polymorphism on the five-factor personality dimensions (assessed using the NEO-FFI), trait depression (assessed with the DASS-21) in a cross-sectional cohort of 467 healthy volunteers. 18548532 2009
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Higher order interaction effects involving BDNF Val(66)Met, 5-HTTLPR and childhood adversity may contribute to the etiology of depressive illness. 17579366 2008