rs6265, BDNF;BDNF-AS

N. diseases: 272
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Parkinson Disease
CUI: C0030567
Disease: Parkinson Disease
0.100 GeneticVariation BEFREE We found that homozygosity for the V66M polymorphism of the brain-derived neurotrophic factor (BDNF) gene occurs more frequently in patients with Parkinson's disease than in unaffected controls (chi(2) = 5.46) and confirmed an association with the S18Y polymorphism of the UCH-L1 gene. 11782995 2002
Mood Disorders
CUI: C0525045
Disease: Mood Disorders
0.100 GeneticVariation BEFREE This study has examined the association between the BDNF gene Val66Met polymorphism and mood disorders, age of onset and suicidal behavior in a Chinese sample population. 14673216 2003
Parkinson Disease
CUI: C0030567
Disease: Parkinson Disease
0.100 GeneticVariation BEFREE Thus, our negative findings suggest that it is unlikely that the BDNF Val66Met polymorphism plays a major role in the pathogenesis of PD in the Chinese population. 14642442 2003
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE The genotype and allele frequencies for the BDNF gene Val66Met polymorphism did not differ comparing depression groups (total, bipolar disorder or major depression) and control subjects. 14673216 2003
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.100 GeneticVariation BEFREE Our finding suggests that this BDNF-gene Val66Met polymorphism may be related to schizophrenia pathogenesis in patients responsive to clozapine treatment. 12951204 2003
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE The genotype and allele frequencies for the BDNF gene Val66Met polymorphism did not differ comparing depression groups (total, bipolar disorder or major depression) and control subjects. 14673216 2003
Major Depressive Disorder
CUI: C1269683
Disease: Major Depressive Disorder
0.100 GeneticVariation BEFREE The present study tested the hypothesis that the BDNF-gene Val66Met polymorphism is associated with MDD, its clinical manifestations, and antidepressant response. 14582140 2003
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE The genotype and allele frequencies for the BDNF gene Val66Met polymorphism did not differ comparing depression groups (total, bipolar disorder or major depression) and control subjects. 14673216 2003
Borderline Personality Disorder
CUI: C0006012
Disease: Borderline Personality Disorder
0.090 GeneticVariation BEFREE There was no evidence for an allelic or genotypic association of two polymorphisms (-1360C>T and 196G>A) of the BDNF gene with BPD. 12524161 2003
Bronchopulmonary Dysplasia
CUI: C0006287
Disease: Bronchopulmonary Dysplasia
0.070 GeneticVariation BEFREE There was no evidence for an allelic or genotypic association of two polymorphisms (-1360C>T and 196G>A) of the BDNF gene with BPD. 12524161 2003
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.100 GeneticVariation BEFREE Our negative findings suggest that it is unlikely that the BDNF Val66Met polymorphism plays a major role in the pathogenesis of AD in the Chinese population and do not support previous findings that homozygosity for the 66Val allele confers an increased risk for AD. 14730194 2004
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.100 GeneticVariation BEFREE A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. 15537879 2004
Parkinson Disease
CUI: C0030567
Disease: Parkinson Disease
0.100 GeneticVariation BEFREE We estimated and compared the haplotype frequencies between C270T and G196A markers in PD and controls that was positive (p = 0.0019). 15120095 2004
Bipolar Disorder
CUI: C0005586
Disease: Bipolar Disorder
0.100 GeneticVariation BEFREE Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder. 15543516 2004
Bipolar Disorder
CUI: C0005586
Disease: Bipolar Disorder
0.100 GeneticVariation BEFREE The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population. 15336520 2004
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.100 GeneticVariation BEFREE Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder. 15543516 2004
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.100 GeneticVariation BEFREE A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. 15537879 2004
Eating Disorders
CUI: C0013473
Disease: Eating Disorders
0.080 GeneticVariation BEFREE This study suggests that the BDNF 196G/A gene polymorphism might be associated with a susceptibility to eating disorders. 15108194 2004
Anorexia Nervosa
CUI: C0003125
Disease: Anorexia Nervosa
0.080 GeneticVariation BEFREE We previously reported a strong association of the Met66 allele of the Val66Met BDNF variant with restricting AN (ANR) and low minimum body mass index in Spanish patients. 15115760 2004
Panic Disorder
CUI: C0030319
Disease: Panic Disorder
0.060 GeneticVariation BEFREE The present study tested the hypothesis that the BDNF gene Val66Met polymorphism is associated with panic disorder. 15118353 2004
Tardive Dyskinesia
CUI: C0686347
Disease: Tardive Dyskinesia
0.050 GeneticVariation BEFREE We concluded that the BDNF val66met genetic polymorphism may exert its effect on the clinically phenotypic variability after TD has occurred. 15626824 2004
Drug-induced tardive dyskinesia
CUI: C3714760
Disease: Drug-induced tardive dyskinesia
0.050 GeneticVariation BEFREE We concluded that the BDNF val66met genetic polymorphism may exert its effect on the clinically phenotypic variability after TD has occurred. 15626824 2004
MAJOR AFFECTIVE DISORDER 2
CUI: C1839839
Disease: MAJOR AFFECTIVE DISORDER 2
0.020 GeneticVariation BEFREE Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder. 15543516 2004
MAJOR AFFECTIVE DISORDER 6
CUI: C1970945
Disease: MAJOR AFFECTIVE DISORDER 6
0.020 GeneticVariation BEFREE Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder. 15543516 2004
MAJOR AFFECTIVE DISORDER 4
CUI: C1970943
Disease: MAJOR AFFECTIVE DISORDER 4
0.020 GeneticVariation BEFREE Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder. 15543516 2004