|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism, resting-state hippocampal functional connectivity and cognitive deficits in acute late-onset depression.
|
26000753 |
2015 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Modulatory effects of the BDNF Val66Met polymorphism on distinct subregions in the prefrontal cortex in MDD support the neurotrophin model of depression.
|
25745134 |
2015 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current study examined the effects of val66met, 5-HTTLPR, and family environment quality on youth depressive symptoms in adolescence and young adulthood in a longitudinal sample oversampled for maternal depression history.
|
25347540 |
2014 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that the Met allele of BDNF Val66Met significantly moderates the relationship between life stress and depression (P = 0.03).
|
24433458 |
2014 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no interaction between depression and Val66Met genotype status.
|
25188405 |
2014 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide polymorphism may be associated with clinical and subsyndromal depression, but physical activity improves mood and increases BDNF expression.
|
24745471 |
2014 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings are in accordance with the previously uncovered pathway between BDNF Val66Met, resting state EEG alpha power, and depression severity.
|
23733090 |
2013 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The 5-HT2A A-1438G, 5-HT2A T102C, BDNF Val66Met, and 5-HT1A C-1019G gene polymorphisms might predict the incidence of depression with ABB.
|
24274373 |
2013 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF val66met polymorphism had no main effect but was moderated by maternal depression, such that children with a BDNF methionine allele had a heightened memory for negative self-descriptive traits when mothers had experienced depression during children's lifetimes; in contrast, children with a methionine allele had low recall of negative traits when mothers had no depression history.
|
23880378 |
2013 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Three-way interaction effect of 5-HTTLPR, BDNF Val66Met, and childhood adversity on depression: a replication study.
|
23481907 |
2013 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study aimed to investigate whether BDNF gene promoter methylation status and val66met polymorphism were associated with depression ascertained at two weeks and one year after stroke.
|
23399480 |
2013 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
No differences in whole blood BDNF was seen in relation to the BDNF Val66Met polymorphism and no significant correlations between whole blood BDNF and HAMD-17 or BDI 21 scores were found.
|
23684538 |
2013 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Both the functional Val66Met BDNF polymorphism (rs6265) and BDNF levels have been associated with depression.
|
23303061 |
2013 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism might be implicated in the pathogenesis of depression in T2DM by decreasing serum BDNF levels in Han Chinese Subjects.
|
23968401 |
2013 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis of studies was conducted to compare the frequency of the BDNF Val66Met variant between cases with geriatric depression and age-matched controls.
|
22610920 |
2012 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Given that BDNF secretion is affected by a common polymorphism (rs6265, Val66Met), which also is associated with depression, we investigated whether this polymorphism modifies the effect of childhood adversity (CA) on local gray matter (GM) volume in depression-relevant brain regions, using data from two large cohorts of healthy subjects.
|
21577214 |
2012 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Discussion The dynamics of serum BDNF levels, but not plasma levels of HVA and MHPG, reflect the response to mirtazapine treatment; the BDNF Val66Met polymorphism in patients with depression is, however, associated with neither a particular response to mirtazapine treatment nor baseline serum BDNF levels.
|
22883353 |
2012 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression.
|
22931410 |
2012 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that in males, BDNF Val66Met interacts with childhood life events, increasing the cognitive susceptibility markers of depression.
|
22033217 |
2012 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The analysis revealed a strong association between the rs6265 genotype distribution and AD-D (p=0.005 after Bonferroni correction), and the A allele of rs6265 was significantly overrepresented in AD-D patients compared to AD without depression (AD-nD) patients (p=0.001 after Bonferroni correction).
|
21880305 |
2011 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Imaging genetics studies have investigated the influence of the serotonin transporter-linked polymorphic region (5HTTLPR) and brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on the hippocampus in healthy individuals and patients with depression (MDD).
|
21692988 |
2011 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects.
|
21420735 |
2011 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Finally, using functional magnetic resonance imaging, we found that viewing sad faces evoked greater activity in d</span>epression-related areas in healthy control subjects possessing the minor alleles of BDNF-rs6265 and CREB1-rs2253206.
|
21215389 |
2011 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
A functional BDNF polymorphism (BDNF Val66Met) was reported to influence the effects of stressful life events or childhood adversity on depression and suicidal behaviour in various psychopathologies.
|
20667416 |
2011 |