|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF (rs6265) and CRY1 (rs2287161) variants have been associated with more depressive symptoms in people with PD.
|
31292011 |
2020 |
|
Depressed mood
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression.
|
30329132 |
2020 |
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
Carriage of BDNF Val66Met has been associated with faster cognitive decline and greater hippocampal atrophy in cognitively normal elderly.
|
31771052 |
2020 |
|
Obsessive-Compulsive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here we studied the association of BDNF polymorphisms rs6265 and rs2883187 with OCD and its clinical characteristics in Iranian patients as well as the fluvoxamine-treatment outcome of OCD patients.
|
31180700 |
2020 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression.
|
30329132 |
2020 |
|
Psychotic Disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome.
|
31822818 |
2019 |
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our analyses suggested the G196A (Val66Met) polymorphism was significantly associated with cog</span>nitive impairment in PD, especially in Caucasian populations.
|
31365694 |
2019 |
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Plasma brain-derived neurotrophic factor (BDNF) concentration and the <i>BDNF</i> Val66Met polymorphism in suicide: a prospective study in patients with depressive disorder.
|
31308724 |
2019 |
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that the BDNF Val66Met variant is not associated with response to antipsychotics in individuals with SCZ.
|
30181602 |
2019 |
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
Functional rs6265 polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in posttraumatic stress disorder among Chinese patients with hepatocellular carcinoma.
|
30659644 |
2019 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The combination of disadvantageous allelic expression of rs6295 and rs6265 may result in a 5-HT<sub>1A</sub> receptor profile comparable to affective disorders as increased 5-HT<sub>1A</sub> receptor binding is a well published phenotype of depression.
|
30664620 |
2019 |
|
Mood Disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
The combination of disadvantageous allelic expression of rs6295 and rs6265 may result in a 5-HT<sub>1A</sub> receptor profile comparable to affective disorders as increased 5-HT<sub>1A</sub> receptor binding is a well published phenotype of depression.
|
30664620 |
2019 |
|
Depressive Symptoms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The objective was to investigate if high cadence cycling altered non-motor cognition and depression symptoms in individuals with Parkinson's disease (PD) and whether exercise responses were influenced by brain-derived neurotrophic factor (BDNF) Val66Met polymorphism.
|
31197095 |
2019 |
|
Obsessive-Compulsive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Regression analysis determined the extent to which psychiatric comorbidity, illness severity, OCD symptom dimensions, childhood trauma history, and the Val66Met (rs6265) polymorphism of the brainderived neurotrophic factor (BDNF) gene predict lifetime suicidal ideation and attempts in adults with OCD.
|
31046037 |
2019 |
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Haplotype GA of rs6265 and G11757C increased the risk of PTSD for HCC, while haplotype CG decreased this risk.
|
30659644 |
2019 |
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis implicates Val66Met BDNF polymorphism may be associated with Parkinson's disease cognitive impairment, further well-designed studies with larger populations are required to validate these results owing to the limited research.
|
31104169 |
2019 |
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
T1-weighted structural magnetic resonance imaging, BDNF rs6265 genotyping through blood sampling, and clinical assessments including the childhood trauma questionnaire (CTQ) and posttraumatic stress disorder Checklist (PCL) were performed.
|
30988377 |
2019 |
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Trend level gene-gender interaction effect for the BDNF rs6265 variant on age of onset of psychosis.
|
31445421 |
2019 |
|
Unipolar Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
|
Anxiety
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the present case-control study was to explore the association between BDNF Val66Met (rs6265) polymorphism and generalized anxiety disorder in Mexican individuals, and whether this polymorphism plays a role in the symptomatology of anxiety.A total of 212 subjects were included in the study.
|
30882674 |
2019 |
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The relationship was investigated between brain-derived neurotrophic factor (BDNF) concentrations, a <i>BDNF</i> polymorphism (196G>A), and the response to selective serotonin reuptake inhibitors (SSRIs) among Chinese patients with major depressive disorder (MDD).
|
31308724 |
2019 |
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pattern of cortical thinning associated with the BDNF Val66Met polymorphism in Parkinson's disease.
|
31202861 |
2019 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Few genetic studies exploring the impact of Val66Met on cognition in BD.
|
30078664 |
2019 |
|
Post-Traumatic Stress Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we examined the relationship between the BDNF Val66Met polymorphism and PTSD symptoms in two nationally representative samples of European American U.S. military veterans (main sample, n = 1386; replication sample, n = 509).
|
30388593 |
2019 |
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
In humans and knock-in mice with a loss of function BDNF SNP (Val66Met), the functionality of this circuit was altered, resulting in social behavioral changes in human and mice.
|
30992540 |
2019 |