rs6265, BDNF;BDNF-AS

N. diseases: 171
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE Brain-Derived Neurotrophic Factor Val66Met Polymorphism Affects the Relationship Between an Anxiety-Related Personality Trait and Resting Regional Cerebral Blood Flow. 27005989 2017
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes. 25640836 2016
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE On the contrary, BDNF met allele carriers showed a reduced acoustic startle response which reached significance in most samples (N1: p=0.004; N2: p=0.045; N3: n.s., N4: p=0.043) pointing to differential effects of BDNF val(66)met on distinct endophenotypes of anxiety and stress-related responses. 26773399 2016
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE Here we comprehensively review the role and relevance of the Val66Met polymorphism in psychiatric disorders, with emphasis on suicidal behavior and anxiety, eating, mood and psychotic disorders. 25824305 2016
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE We investigated the effect of brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism on the severity of depressive and anxiety symptoms in never-smokers, former smokers, non-dependent, and nicotine-dependent smokers with a current diagnosis of depression and/or anxiety. 25618300 2015
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE Gene-environment interaction effects were detected between the BDNF-Val66Met polymorphism and maternal care on phobic anxiety, paternal care on hostility, maternal overprotection on somatization and paternal overprotection also in somatization. 24768157 2015
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE The Val/Val genotype of the brain-derived neurotrophic factor (BDNF) polymorphism (Val66Met) has been reported to affect human anxiety-related phenotypes. 25001952 2015
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE We aimed to explore whether anxiety in BD offspring was associated with the BDNF Val66Met polymorphism.64 BD offspring (mean age: 13.73 (S.D. 25498133 2015
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE The Met allele of BDNF Val66Met may be predictive of an anxious coping style in patients with advanced cancer. 24913346 2014
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE Because the Val/Val genotype of the BDNF Val66Met polymorphism, rather than the other two polymorphisms, has been associated with anxiety, it seems to affect BP-I comorbid with AD without the involvement of the DRD3 Seg9Gly polymorphism, but may modify the involvement of DRD3 Gly/Gly in BP-II comorbid with AD. 24021960 2014
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE Gray matter volume in adolescent anxiety: an impact of the brain-derived neurotrophic factor Val(66)Met polymorphism? 23357445 2013
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE BDNF Val66Met polymorphism is associated with higher anticipatory cortisol stress response, anxiety, and alcohol consumption in healthy adults. 21596481 2012
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE BDNF gene polymorphism (Val66Met) predicts amygdala and anterior hippocampus responses to emotional faces in anxious and depressed adolescents. 19931400 2011
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE In line with recent studies investigating the role of BDNF Val66Met and DRD2/ANKK1 Taq IA polymorphisms on anxiety and gray matter volume in the ACC, our findings provide the first evidence for a genetic contribution to alexithymia. 21097659 2011
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE A common polymorphism of the brain-derived neurotrophic factor (BDNF) gene (Val66Met) has been implicated in anxiety, which is associated with lower vagal activity. 20213725 2010
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. 19582565 2010
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. 19153574 2009
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE Interaction between BDNF Val66Met and dopamine transporter gene variation influences anxiety-related traits. 17392738 2008
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression. 17941097 2008
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE Moreover, the Val66Met polymorphism was correlated with improvements in core, activity, and psychic anxiety symptoms. 16979146 2007
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE Assuming that BDNF may be implicated in the putative common pathophysiology of depression and anxiety, we analyzed the association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (formerly named C270T) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with panic disorder. 15913870 2005
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects. 15770238 2005