rs6265, BDNF;BDNF-AS

N. diseases: 171
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE Association of Val66Met polymorphism at brain derived neurotrophic factor gene with depression among Chinese adolescents after Wenchuan earthquake: An 18months longitudinal study. 28527683 2018
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE Two recent papers associated candidate genes with brooding rumination, a possible cognitive endophenotype for depression, in children ages 8-14 years.Stone et al. reported that BDNF val66met polymorphism predicted brooding in adolescence.Woody et al. reported that children carrying at least one copy of a CRHR1 TAT haplotype reported less brooding than their peers in the presence of maternal depression. 27073970 2018
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE Association of BDNF Val66MET Polymorphism With Parkinson's Disease and Depression and Anxiety Symptoms. 27852165 2017
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE Depression in multiple sclerosis: effect of brain derived neurotrophic factor Val66Met polymorphism and disease perception. 26756166 2016
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE We investigated the independent and interactive effects of BDNF methylation and val66met polymorphism on late-life depression. 25648279 2016
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE Three single-nucleotide polymorphisms (rs6265, rs7103411 and rs908867) were also found to modify the association between depression and promoter I methylation. 26285129 2016
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE Associations between the BDNF val66met polymorphism and both depression status and treatment response were investigated using logistic regression models. 26795846 2016
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE Modulatory effects of the BDNF Val66Met polymorphism on distinct subregions in the prefrontal cortex in MDD support the neurotrophin model of depression. 25745134 2016
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE Additionally, the association between DED and Val66Met may vary by depression status. 26393465 2016
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism, resting-state hippocampal functional connectivity and cognitive deficits in acute late-onset depression. 26000753 2016
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE The influence of 5-HTTLPR and Val66Met polymorphisms on cortical thickness and volume in limbic and paralimbic regions in depression: a preliminary study. 26976307 2016
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE We investigated the effect of brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism on the severity of depressive and anxiety symptoms in never-smokers, former smokers, non-dependent, and nicotine-dependent smokers with a current diagnosis of depression and/or anxiety. 25618300 2015
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression. 22931410 2015
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE The serotonin transporter linked polymorphic region and brain-derived neurotrophic factor valine to methionine at position 66 polymorphisms and maternal history of depression: associations with cognitive vulnerability to depression in childhood. 23880378 2014
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE Both the functional Val66Met BDNF polymorphism (rs6265) and BDNF levels have been associated with depression. 23303061 2014
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE Three-way interaction effect of 5-HTTLPR, BDNF Val66Met, and childhood adversity on depression: a replication study. 23481907 2014
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE Interaction between stress and the BDNF Val66Met polymorphism in depression: a systematic review and meta-analysis. 24433458 2014
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE Discussion The dynamics of serum BDNF levels, but not plasma levels of HVA and MHPG, reflect the response to mirtazapine treatment; the BDNF Val66Met polymorphism in patients with depression is, however, associated with neither a particular response to mirtazapine treatment nor baseline serum BDNF levels. 22883353 2013
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE This study aimed to investigate whether BDNF gene promoter methylation status and val66met polymorphism were associated with depression ascertained at two weeks and one year after stroke. 23399480 2013
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE A brain-derived neurotrophic factor (BDNF) prodomain single-nucleotide polymorphism resulting in a valine to methionine substitution (Val66Met) has been associated with depression-related phenotypes and brain alterations involving regions consistently associated with major depressive disorder (MDD). 23165919 2013
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE The analysis revealed a strong association between the rs6265 genotype distribution and AD-D (p=0.005 after Bonferroni correction), and the A allele of rs6265 was significantly overrepresented in AD-D patients compared to AD without depression (AD-nD) patients (p=0.001 after Bonferroni correction). 21880305 2012
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE The brain-derived neurotrophic-factor (BDNF) val66met polymorphism is associated with geriatric depression: a meta-analysis. 22610920 2012
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE Given that BDNF secretion is affected by a common polymorphism (rs6265, Val66Met), which also is associated with depression, we investigated whether this polymorphism modifies the effect of childhood adversity (CA) on local gray matter (GM) volume in depression-relevant brain regions, using data from two large cohorts of healthy subjects. 21577214 2012
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE The results suggest that in males, BDNF Val66Met interacts with childhood life events, increasing the cognitive susceptibility markers of depression. 22033217 2012
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE Imaging genetics studies have investigated the influence of the serotonin transporter-linked polymorphic region (5HTTLPR) and brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on the hippocampus in healthy individuals and patients with depression (MDD). 21692988 2012