rs6265, BDNF;BDNF-AS

N. diseases: 171
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The Brain-Derived Neurotrophic Factor Val66Met Polymorphism, Delivery Method, Birth Weight, and Night Sleep Duration as Determinants of Obesity in Vietnamese Children of Primary School Age. 28471701 2018
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The positive association of BNDF Val66Met with high BMI values replicates previous findings in patients with SCZ and indicates the BDNF Val66Met genotype as a potential risk factor for obesity and insulin resistance measures in patients with BPD receiving antipsychotics as well. 25874530 2016
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Variants in BDNF, in particular the functional Val66Met polymorphism (rs6265), have been found to be associated with a number of psychiatric disorders, cognitive function, and obesity. 24708359 2015
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE In a partial replication of prior research, the obesity risk (G) allele at BDNF rs6265 was associated with greater weight regain across treatment arms (0.773 kg per risk allele), although results were of borderline statistical significance (P=0.051). 23628854 2014
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The interaction effect between BDNF val66met polymorphism and obesity on executive functions and frontal structure. 24619555 2014
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Our study replicates the statistically significant association of four SNPs (FTO rs9939609, MC4R rs17782313, GNPDA2 rs10938397, BDNF rs6265) with risk of central obesity in the Chinese children. 23424664 2013
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The aim of this study was to determine the association between the gene variants of the BDNF Val66Met polymorphism and obesity in 300 healthy Caucasian children and adolescents of the same ethnic background of Croatian origin, subdivided according to the BMI percentile, but without any form of eating disorders. 21851847 2012
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Most notably, the association between 5 SNPs (Fas apoptotic inhibitory molecule 2 rs7138803, Niemann-Pick disease, type C1 rs1805081, fat mass- and obesity-associated gene rs6499640, melanocortin 4 receptor gene rs17782313, and brain-derived neurotrophic factor rs6265) and obesity risk was only observed in children who had moderate-to-low physical activity levels or engaged in sedentary behavior, regardless of which risk alleles they carried. 21527513 2011
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE After age and sex adjustment and correction for multiple testing, the SNPs rs17782313, rs6265, and rs10938397 were associated with BMI (P = 1.0 × 10⁻⁵, 0.038, and 0.00093, respectively) and also obesity (P = 5.0 × 10⁻⁶, 0.043, and 0.00085, respectively) in the Chinese children. 20843981 2010
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Association of the BDNF Val66Met variation with obesity in women. 18667348 2008
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE No association was found between the BDNF G196A (Val66Met) polymorphism and diabetes or obesity. 17151862 2007
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE We found no association between p.V66M or the additionally genotyped variant c.-46C > T and obesity, ADHD or eating disorders. 15457498 2005