Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that the BDNF Val66Met variant is not associated with response to antipsychotics in individuals with SCZ.
|
30181602 |
2019 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Traumatic experiences and cognitive profiles of schizophrenia cases influenced by the BDNF Val66met polymorphism.
|
30472504 |
2019 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism results in reduced activity-dependent BDNF release and has been implicated in schizophrenia.
|
28864281 |
2018 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further studies will be required in this area to confirm the effect of the BDNF Val66Met polymorphism in the pathophysiology of schizophrenia and patients' response to antipsychotic drugs, especially in a larger sample size and in different ethnic populations.
|
30312750 |
2018 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
196G/A of the Brain-Derived Neurotrophic Factor Gene Polymorphisms Predicts Suicidal Behavior in Schizophrenia Patients.
|
29898578 |
2018 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A significant association of rs6265 AA + AG × rs1799964 CC + CT with schizophrenia was observed (OR = 1.14, 95%CI: 1.02-1.27; P = .02).
|
29306772 |
2018 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significant 2-way interactions were found for Val66Met × PN, 3-way interactions were found for Val66Met × PN × PA, and four-way interactions were found for Val66Met × PN × PA × EN with regard to the excitement scores.Our findings suggested an involvement of BDNF Val66Met polymorphism after ChT in terms of risk for schizophrenia symptoms.
|
29595641 |
2018 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism itself and its interaction with some clinical variables may influence suicide attempts among schizophrenia patients.(PsycINFO Database Record
|
28857598 |
2018 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val66Met functional polymorphism and serum protein level of brain-derived neurotrophic factor (BDNF) in acute episode of schizophrenia and depression.
|
29331787 |
2018 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism, which results in deficient activity-dependent secretion of BDNF, is associated with clinical features of schizophrenia.
|
27262112 |
2017 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
DNA methylation profiles were generated for CpG sites proximal to Val66Met, within BDNF promoter I and exon V for prefrontal cortex samples from 25 schizophrenia and 25 control subjects.
|
27712141 |
2017 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Studies have also shown that the BDNF Val66Met polymorphism was associated with weight gain in patients with schizophrenia on long-term antipsychotic treatment.
|
27483421 |
2016 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This article reviews the current literature available regarding associations between the Val66Met polymorphism, childhood trauma and cognitive dysfunction in schizophrenia.
|
26603624 |
2016 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was a significant association between BDNF Val66Met polymorphism and schizophrenia in our meta-analysis study.
|
26134309 |
2016 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of the brain-derived neurotrophic factor Val66Met polymorphism with negative symptoms severity, but not cognitive function, in first-episode schizophrenia spectrum disorders.
|
27668551 |
2016 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that BDNF rs6265 methylation interacts with genotype to bridge early environmental exposures to adult phenotypes, relevant for schizophrenia.
|
26889735 |
2016 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val66Met (also known as rs6265 or G196A), the only known functional polymorphism of the BDNF gene, has been widely studied and considered to be associated with risk of some psychiatric disorders such as bipolar disorder and schizophrenia.
|
26503495 |
2015 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the BDNF Val66Met polymorphism may affect a smoker's response to nicotine in both schizophrenia and healthy controls from a Chinese Han population, but with differential effects in different aspects of smoking behaviors.
|
25455509 |
2015 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The functional BDNF single nucleotide polymorphism (SNP) rs6265 ha</span>s been associated with many disorders including schizophrenia and alcohol dependence.
|
24993285 |
2015 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The positive association of BNDF Val66Met with high BMI values replicates previous findings in patients with SCZ and indicates the BDNF Val66Met genotype as a potential risk factor for obesity and insulin resistance measures in patients with BPD receiving antipsychotics as well.
|
25874530 |
2015 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We argue that while the Val66Met polymorphism may not be a major risk-conferring agent for the development of schiz</span>ophrenia per se, there is mounting evidence that the polymorphism modulates a range of clinical features of the illness, including age of onset, symptoms, therapeutic responsiveness, neurocognitive function and brain morphology.
|
25562189 |
2015 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this sample, we found a possible interaction between the BDNF Val66Met and DRD3 Ser9Gly SNPs in increasing the risk of suicide attempt(s) in our SCZ sample.
|
25264289 |
2015 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analyses did not robustly establish an association between BDNF Val66Met polymorphism and neurocognition in schizophrenia.
|
25681004 |
2015 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
These preliminary findings support the notion of an association of the BDNF-Val66Met-polymorphism with observable alterations in plasticity following cathodal tDCS in schizophrenia patients.
|
25612896 |
2014 |
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
It was also detected that, compared to individuals homozygous for the standard allele (G/G) of rs6265, carriers of the rs6265 minor allele (A/G+A/A), which is significantly more frequent in schizophrenia patients than in controls, had decreased BDNF levels.
|
24713399 |
2014 |