rs6265, BDNF;BDNF-AS

N. diseases: 272
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE Thus, we assessed whether the functional single nucleotide polymorphism (SNP) on the BDNF gene, Val66Met, moderated the relationship between depressive symptoms and perceived social support and unsupportive relationships, and whether these associations differed by gender. 31364951 2020
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE BDNF (rs6265) and CRY1 (rs2287161) variants have been associated with more depressive symptoms in people with PD. 31292011 2020
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE The objective was to investigate if high cadence cycling altered non-motor cognition and depression symptoms in individuals with Parkinson's disease (PD) and whether exercise responses were influenced by brain-derived neurotrophic factor (BDNF) Val66Met polymorphism. 31197095 2019
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE Our results suggest a close relationship between job-related stress and depression, and the interaction of the BDNF Val66Met polymorphism and chronic stress in adulthood may impact the depressive symptoms. 29734099 2018
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE A BDNF Val66Met × Harsh Parenting interaction predicted the rise in depressive symptoms across a 3-year period, whereas a 5-HTTLPR × Harsh Parenting interaction predicted greater frequency in elevated depressive symptoms. 27736236 2018
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE Our investigation assessed whether indices of white matter integrity, serotonin transporter-linked polymorphism (5-HTTLPR) and brain-derived neurotrophic factor (BDNF) val66met polymorphism predicted magnitude of depression symptom change following antidepressant treatment. 27277475 2017
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE i) GG homozygotes (rs1475157-NRN1) showed higher scores on BSI depressive dimension and on total scores compared to A carriers (corrected p-values: 0.0004 and 0.0003, respectively). ii) a linear trend was detected between GG genotype of rs1475157 and a worse cognitive performance in WCST total correct responses (uncorrected p-value: 0.029). iii) Interaction between rs1475157-NRN1 and Val66Met-BDNF was found to modulate depressive symptoms (p=0.001, significant after correction). 28107668 2017
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE There was a significant interaction between C-reactive protein (CRP) and the BDNF Val66met polymorphism in predicting cognitive depressive symptoms (p=.004), such that higher CRP was related to more cognitive depressive symptoms among Met allele carriers, but not among Val/Val homozygotes. 26967918 2016
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE Among Aβ+ women, ε4 carriers reported greater anxiety symptoms than non-ε4 carriers (d = 0.83), and female BDNF rs6265 Val66 Met allele carriers reported greater depressive symptoms (d = 0.29). 27742526 2016
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE Results indicated the BDNF Val66Met polymorphism significantly moderated the influence of maternal warmth-reasoning, but not harshness-hostility, on youth depressive symptoms. 26510938 2016
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE The present study has provided the first examination of whether working memory capacity, the BDNF Val66Met polymorphism, and their interaction predict changes in symptoms of depression during the transition to university. 24920443 2015
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE We modeled the interactive effects of peer victimization with three genetic polymorphisms (on 5-HTTLPR, DRD2 TaqIA, and BDNF Val66Met) on depressive symptoms. 24819687 2015
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE This study represents the first replication of the BDNF Val66Met ⁎ 5-HTTLPR ⁎ childhood maltreatment effect on self-reported depression symptoms using a rigorous maltreatment interview. 26070769 2015
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE The current study examined the effects of val66met, 5-HTTLPR, and family environment quality on youth depressive symptoms in adolescence and young adulthood in a longitudinal sample oversampled for maternal depression history. 25347540 2014
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE We conclude that the BDNF Val66Met polymorphism influenced responses to add-on memantine by decreasing depressive symptoms in patients with BP-II. 24103632 2014
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE In midlife, the BDNF Val66Met polymorphism neither attenuates nor magnifies the effect of physical activity on depressive symptoms. 24745471 2014
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE Furthermore, the BDNF Val66Met polymorphism is a significant factor influencing the severity of anxiety/depression symptoms in schizophrenic patients. 23532065 2013
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE The BDNF val66met polymorphism was independently associated with prevalent PSD, but not with persistent and incident PSD nor with depressive symptoms severity. 23399480 2013
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE The Role of the Val66Met Polymorphism of the Brain Derived Neurotrophic Factor Gene in Coping Strategies Relevant to Depressive Symptoms. 23824678 2013
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE BDNF Val 66 Met and 5-HTTLPR genotype moderate the impact of early psychosocial adversity on plasma brain-derived neurotrophic factor and depressive symptoms: a prospective study. 23058261 2013
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE Both 5-HTTLPR and BDNF Val66Met interacted with unfavourable environment in relation to depressive symptoms (Adj R²=0.19). 23481907 2013
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE Brain-derived neurotrophic factor (BDNF) Val66Met and adulthood chronic stress interact to affect depressive symptoms. 23140671 2013
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE We found that the BDNF rs6265 polymorphism was related to the severity of depressive symptoms, and that this association was independent of neurotransmitter levels. 21898033 2012
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE The frequency of stressful life events was significantly correlated with depressive symptoms (twin1: β = 0.21, P = 0.01; twin2: β = 0.27, P < 0.01), but there was no significant main effect of the BDNF Val66Met genotype on depressive symptoms. 22931410 2012
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects. 21420735 2011