Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Behavioral and psychological symptoms of dementia
0.020 GeneticVariation BEFREE Thus, the BDNF Val66Met polymorphism exerts an increase in glutamatergic transmission but impairs synaptic plasticity in the dorsal striatum, which might play a role in its effect on neuropsychiatric symptoms. 27378336 2017
Behavioral and psychological symptoms of dementia
0.020 GeneticVariation BEFREE In the present study, we examined whether neuropsychiatric symptoms were correlated with plasma brain-derived neurotrophic factor (BDNF) levels as a state marker or were associated with the BDNF polymorphism Val66Met in patients with amnestic mild cognitive impairment (A-MCI) or Alzheimer disease (AD). 24253237 2014