rs6473, CYP21A2;TNXB

N. diseases: 4
Disease: Autoimmune Primary Adrenal Insufficiency ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Autoimmune Primary Adrenal Insufficiency
CUI: C2103602
Disease: Autoimmune Primary Adrenal Insufficiency
0.010 GeneticVariation BEFREE Heterozygotes of the single-nucleotide polymorphisms (SNPs) rs397515394, rs6467, rs6474, rs76565726 and rs6473 were detected significantly more frequently in AAD patients compared with HC (P<0.005), but all SNPs were in a linkage disequilibrium (LD) with high-risk HLA-DRB1 haplotypes. rs6472C protected against AAD (odds ratio=0.15, 95% CI (0.08-0.30), P=3.8×10(-10)). 25249698 2014