|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We aimed to investigate the association between polymorphisms in several cholesterol-related genes [APOA5 (rs662799), APOC1 (rs11568822), APOD (rs1568565), CH25H (rs13500), LDLR (rs5930), SORL1 (rs2282649)] and AD in a cohort of Turkish patients.
|
30684189 |
2019 |
|
Anemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms of the genes MTHFR (rs1801133) and APOA5 (rs662799), as well as anemia, are independent risk factors for stroke in Mexicans, together with traditional cardiovascular risk factors such as high triglycerides and high blood pressure.
|
29398535 |
2018 |
|
Anemia, Sickle Cell
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms in genes that affect the variation of lipid levels in a Brazilian pediatric population with sickle cell disease: rs662799 APOA5 and rs964184 ZPR1.
|
31670185 |
2020 |
|
Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results show that two APOA5 variants, rs662799 (-1131T>C) and rs2075291 (c.553G>T), are associated with HDL-cholesterol levels in a Korean population, and suggest that individuals with an APOA5 rs662799 CC genotype are at higher risk of atherosclerosis, particularly when they have low HDL-cholesterol, and this association is related to adiponectin levels.
|
30132804 |
2018 |
|
Atherogenic dyslipidaemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, polymorphisms in genes associated to the development of atherogenic dyslipidemia, especially variants in APOA5 gene (rs3135506 and rs662799), can influence the circulating CD4 T-cell levels in chronically HIV-infected patients.
|
25500319 |
2015 |
|
Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results show that two APOA5 variants, rs662799 (-1131T>C) and rs2075291 (c.553G>T), are associated with HDL-cholesterol levels in a Korean population, and suggest that individuals with an APOA5 rs662799 CC genotype are at higher risk of atherosclerosis, particularly when they have low HDL-cholesterol, and this association is related to adiponectin levels.
|
30132804 |
2018 |
|
Avascular Necrosis of Femur Head
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found both rs662799 and rs3135506 were associated with the risk of ONFH in codominant, dominant, and recessive model, respectively.
|
25515090 |
2014 |
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms of the genes MTHFR (rs1801133) and APOA5 (rs662799), as well as anemia, are independent risk factors for stroke in Mexicans, together with traditional cardiovascular risk factors such as high triglycerides and high blood pressure.
|
29398535 |
2018 |
|
Chronic Kidney Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Logistic regression analysis revealed that SNPs APOA5 T - 1131C (rs662799), APOA5 T1259C (rs2266788), TOMM40 A/G (rs157580), and CETP TaqIB (rs708272) were significantly associated with CKD risk in those individuals genotyped, with age- and sex-adjusted odds ratios (ORs) per minor allele (and 95% confidence intervals (CIs)) of OR 1.22 (95% CI: 1.06-1.39), 1.19 (1.03-1.37), 1.27 (1.12-1.45), and 0.81 (0.71-0.92), respectively.
|
25311932 |
2014 |
|
Coronary Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We assessed the -1131T>C (rs662799) promoter polymorphism of the apolipoprotein A5 (APOA5) gene in relation to triglyceride concentration, several other risk factors, and risk of coronary heart disease.
|
20452521 |
2010 |
|
Coronary Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The APOA5 rs662799 polymorphism is associated with dyslipidemia and the severity of coronary heart disease in Chinese women.
|
27716220 |
2016 |
|
Coronary Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis.
|
26309253 |
2015 |
|
Coronary Artery Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
The APOA5 rs662799 polymorphism is associated with dyslipidemia and the severity of coronary heart disease in Chinese women.
|
27716220 |
2016 |
|
Coronary Artery Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
Aim was to estimate the genotypic distribution and risk allele frequencies of 13 Coronary Artery Disease (CAD) risk Single Nucleotide Polymorphisms in loci identified by the CARDIoGRAMplusC4D consortium namely MIA3 rs17465637; 9p21 rs10757274; CXCL12 rs1746048; APOA5 rs662799; APOB rs1042031; LPA rs3798220; LPA 10455872; MRAS rs9818870; LPL rs328; SORT1 rs646776; PCSK9 rs11591147; APOE rs429358; APOE rs7412 in Pakistani PCAD patients and controls.
|
28705542 |
2019 |
|
Coronary Artery Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
Polymerase chain reaction-based genotyping of PON1 Q192R (rs662) and APOA5-1131T>C (rs662799) polymorphism was carried out in 520 individuals, including 250 CAD patients (160 with T2DM and 90 without T2DM), 150 T2DM patients with no identified CAD, and 120 normal healthy sex- and age-matched individuals as controls.
|
21438666 |
2011 |
|
Coronary Artery Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis.
|
26309253 |
2015 |
|
Coronary Artery Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
CAD association was replicated and/or verified for 4 loci: SORT1 rs611917 (p=1.7 × 10(-8)), APOA5 rs662799 (p=0.0014), LDLR rs1433099 (p=2.1 × 10(-7)), and APOE rs7412 (p=6.1 × 10(-13)).
|
23050023 |
2012 |
|
Coronary Artery Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
<i>APOA5</i> SNPs rs662799 and rs651821 exhibited significant differences in genotype and allele distributions between patients with CAD and control subjects.
|
29866721 |
2018 |
|
Coronary Artery Disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
We assessed the -1131T>C (rs662799) promoter polymorphism of the apolipoprotein A5 (APOA5) gene in relation to triglyceride concentration, several other risk factors, and risk of coronary heart disease.
|
20452521 |
2010 |
|
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our data indicate that the rs662799 polymorphism is associated with dyslipidemia and the severity of CHD in Chinese women.
|
27716220 |
2016 |
|
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
In addition, our results suggest a male-specific association between the APOA5 rs662799 polymorphism and CHD</span>.
|
26309253 |
2015 |
|
Coronary heart disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
We assessed the -1131T>C (rs662799) promoter polymorphism of the apolipoprotein A5 (APOA5) gene in relation to triglyceride concentration, several other risk factors, and risk of coronary heart disease.
|
20452521 |
2010 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
In current study two SNPs rs662799 risk allele G (P = 0.03) and rs3135506 risk allele C (P = 0.05) of APOA5 were found to be associated with significant higher risk of triglyceride levels, irrespective of age, sex, obesity, diabetes, hypertension and smoking.
|
24402875 |
2014 |
|
Diabetes Mellitus
|
|
0.020 |
GeneticVariation
|
BEFREE |
In current study two SNPs rs662799 risk allele G (P = 0.03) and rs3135506 risk allele C (P = 0.05) of APOA5 were found to be associated with significant higher risk of triglyceride levels, irrespective of age, sex, obesity, diabetes, hypertension and smoking.
|
24402875 |
2014 |
|
Diabetes Mellitus
|
|
0.020 |
GeneticVariation
|
BEFREE |
Multivariable logistic regression analysis of combined genotypes with adjustment for age, gender and diabetes mellitus revealed that rs662799 and rs6929846 significantly and synergistically affected dyslipidemia.
|
22576629 |
2012 |