|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data showed an association of MetS at the genome-wide significance level (<i>P</i> < 8.6 x 10<sup>-8</sup>) with two SNPs, including the rs662799 SNP in the apolipoprotein A5 (<i>APOA5</i>) gene and the rs16944558 SNP in the collectin subfamily member 12 (<i>COLEC12</i>) gene.
|
29212154 |
2017 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
It seems that APOA5 rs2075291 could play an important role in triglyceride and HDL-C level in metabolic syndrome affected, while the association of APOA5 rs662799 polymorphism is still under debate.
|
26702748 |
2016 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data showed a nominal association of MetS with the APOA5 rs662799, BUD13 rs11216129, BUD13 rs623908, CETP rs820299, and LIPA rs1412444 single nucleotide polymorphisms (SNPs).
|
27827461 |
2016 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found that rs</span>662799 near APOA5 and rs769450 in APOE had significant association with MetS and its components.
|
26365620 |
2015 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
Of these SNPs, five SNPs were significantly associated with MetS (P < 0.05): LRP2 rs2544390, rs1800592 between UCP1 and TBC1D9, APOA5 rs662799, VWF rs7965413, and rs1411766 between MYO16 and IRS2.
|
25646961 |
2015 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
We demonstrate that except of TG, Apo A5 T-1131C (rs662799) and Apo E (rs429358, rs7412) polymorphisms have no remarkable effect on MetS characteristics.
|
24709297 |
2014 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of APOA5 -1131T>C (rs662799) on fasting plasma lipids and risk of metabolic syndrome: evidence from a case-control study in China and a meta-analysis.
|
23468858 |
2013 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
We previously showed that the -1131T→C polymorphism (rs662799) of the apolipoprotein A-V gene (APOA5) and the C→T polymorphism (rs6929846) of the butyrophilin, subfamily 2, member A1 gene (BTN2A1) were significantly associated with an increased serum concentration of triglycerides, a decreased serum concentration of high density lipoprotein (HDL)-cholesterol, and the prevalence of metabolic syndrome (MetS) in Japanese individuals.
|
22576629 |
2012 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
After correcting for multiple testing (p<0.05) and accounting for significant differences in the association effect sizes between subjects with and without MetS (p<0.05), variants of APOA5 (rs662799) and APOE (rs429358) were associated with HDL-C and LDL-C responses in MetS subjects, while APOA4 (rs675) was associated with TG response in non-MetS subjects.
|
21324458 |
2011 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of rs662799 with the number of the MetS</span> components was significant regardless of age, sex, obesity and alcohol drinking, but almost disappeared after further adjusting for plasma triglycerides.
|
21054477 |
2011 |