|
Inflammatory Bowel Diseases
|
|
0.820 |
GeneticVariation
|
BEFREE |
IL12B rs6871626 did not show an association with IBD-TA compared with that with TA without IBD.
|
28449344 |
2017 |
|
Inflammatory Bowel Diseases
|
|
0.820 |
GeneticVariation
|
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Inflammatory Bowel Diseases
|
|
0.820 |
GeneticVariation
|
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Inflammatory Bowel Diseases
|
|
0.820 |
GeneticVariation
|
BEFREE |
Here, we conducted a multiple-stage genetic association study of 133 IBD susceptibility loci in multiple leprosy samples (totaling 4,971 leprosy cases and 5,503 controls) from a Chinese population and discovered two associations at rs2058660 on 2q12.1 (p = 4.57 × 10(-19); odds ratio [OR] = 1.30) and rs6871626 on 5q33.3 (p = 3.95 × 10(-18); OR = 0.75), implicating IL18RAP/IL18R1 and IL12B as susceptibility genes for leprosy.
|
23103228 |
2012 |
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
GWASDB |
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
|
21297633 |
2011 |
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
|
21297633 |
2011 |
|
Ankylosing spondylitis
|
|
0.730 |
GeneticVariation
|
BEFREE |
Interleukin 12B (rs6871626) and IL-6R (rs4129267) gene polymorphisms could serve as promising biomarkers for diagnosis and prognosis in AS patients.
|
29200018 |
2018 |
|
Ankylosing spondylitis
|
|
0.730 |
GeneticVariation
|
BEFREE |
Our study is the first to show that rs4937362/RP11-264E20.1 is associated with AS and that rs6871626 is associated with VKH disease in Chinese Han.
|
29490353 |
2018 |
|
Ankylosing spondylitis
|
|
0.730 |
GeneticVariation
|
BEFREE |
The significant difference was found in genotype distribution between AS and healthy controls (χ2 = 6.942, P-value = 0.031) of the SNP rs6871626</span>.
|
26103568 |
2015 |
|
Ankylosing spondylitis
|
|
0.730 |
GeneticVariation
|
GWASCAT |
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci.
|
23749187 |
2013 |
|
Takayasu Arteritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
A previous study revealed the association between susceptibility to Takayasu arteritis (TAK) and a single nucleotide polymorphism (SNP) rs6871626 located in IL12B, which encodes interleukin (IL)-12p40, a common component of IL-12p70 and IL-23.
|
28874185 |
2017 |
|
Takayasu Arteritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
IL12B rs6871626 did not show an association with IBD-TA compared with that with TA without IBD.
|
28449344 |
2017 |
|
Takayasu Arteritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
We demonstrated a allele association between the four SNPs of IL12B and TA (rs6871626: OR 1.52, 95% CI 1.26-1.83; rs4921492: OR 1.46, 95% CI 1.21-1.75; rs60689680: OR 1.41, 95% CI 1.17-1.69; rs4921493: OR 1.45, 95% CI 1.21-1.75, all P <sub>c</sub> < 10<sup>- 3</sup> ).
|
28160070 |
2017 |
|
Takayasu Arteritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Thus, our study points to potential diagnostic use of SNP rs6871626 for predicting disease severity of TAK, with the goal of genotyping-oriented therapy in the near future.
|
25783557 |
2016 |
|
Takayasu Arteritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
We also found that rs6871626 showed a significant association with clinical manifestations of TAK, including increased risk and severity of aortic regurgitation, a representative severe complication of TAK.
|
23830516 |
2013 |
|
Aortic Valve Insufficiency
|
|
0.010 |
GeneticVariation
|
BEFREE |
We also found that rs6871626 showed a significant association with clinical manifestations of TAK, including increased risk and severity of aortic regurgitation, a representative severe complication of TAK.
|
23830516 |
2013 |