|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
|
30926973 |
2019 |
|
Serum total cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
Serum total cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.
|
22629316 |
2012 |
|
Serum total cholesterol measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Cardiovascular Diseases
|
|
0.710 |
GeneticVariation
|
BEFREE |
In a previous study, analysis of the genetic LDLR variant rs688 provided evidence suggesting that genetic polymorphisms of rs688 are associated with thrombotic cardiovascular diseases.
|
24295502 |
2014 |
|
Cardiovascular Diseases
|
|
0.710 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.
|
18179892 |
2008 |
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.
|
22629316 |
2012 |
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Hepatitis C
|
|
0.020 |
GeneticVariation
|
BEFREE |
We did observe a significant association for rs688 within the LDL-R gene with HCV infection (OR: 0.41 P = 0.001), however, LDL cholesterol levels did not vary between individuals carrying the differential SNPs.
|
30260075 |
2019 |
|
Hepatitis C
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, SNPs previously associated with this trait and allocated within the LDLR gene, rs5925 and rs688, were also associated with this condition in our study under a dominant model (24 out of 27 [88.9%] rs5925-C carriers in the HRSN group vs 560 of 804 [69.6%] rs5925-C carriers in the HCV-seropositive group, P = 0.031, odds ratio [OR] = 3.48; 95% confidence interval [CI] = 1.04-11.58; and 24 out of 27 [88.9%] rs688-T carriers in the HRSN group vs 556 of 804 [69.1%] rs688-T carriers in the HCV-seropositive group, P = 0.028, OR = 3.57, 95% CI = 1.65-11.96).
|
31206233 |
2019 |
|
Ischemic stroke
|
|
0.020 |
GeneticVariation
|
BEFREE |
The interaction effects of rs688 C/T with ApoA5 rs662799 A/G and CETP rs708272 C/T promoted the occurrence of IS.
|
28623937 |
2017 |
|
Ischemic stroke
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results not only demonstrated potential interactions of APOE epsilon2/epsilon3/epsilon4 and LDLR C1773T polymorphisms with risk of having ischemic stroke, but also added the evidence of independent role of hypertension and APOE epsilon2/epsilon3/epsilon4 polymorphism in the development of this disorder in Northern Han Chinese.
|
18851860 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
PECAM-1 Leu125Val (rs688) Polymorphism and Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus.
|
28116228 |
2016 |
|
Diabetic Nephropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
We analyzed the rs688 single nucleotide polymorphism of <i>PECAM-1</i> gene C373G (Leu125Val) at exon 3, which encodes the first extracellular Ig-like domain that mediates the homophilic binding of PECAM-1, in 276 T2DM subjects with documented DN (cases) and 375 T2DM subjects without DN (controls), using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) strategy.
|
28116228 |
2016 |
|
Cerebral Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study aimed to explore 2 genetic LDLR variants, rs688 and rs5925, for their potential roles in cerebral infarction.
|
22621231 |
2012 |
|
Infarction, Lacunar
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, when analyzing the association between the haplotypes related to rs688 and rs5925 and cerebral ischemic stroke, the most common haplotype allele CT was used as the reference allele, and the haplotype TC associated with a 65% increased risk of overall ischemic stroke, 72% increased risk of atherothrombotic stroke, and 70% increased risk of lacunar infarction; this indicated a synergistic effect between these 2 single-nucleotide polymorphisms.
|
22621231 |
2012 |
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate 3 single nucleotide polymorphisms in SMARCA4-LDLR gene locus (rs1122608, rs2228671, and rs688) and FVIII coagulant activity (FVIII:c) in subjects with (n = 692) or without (n = 291) angiographically confirmed coronary artery disease (CAD).
|
20810930 |
2010 |
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate 3 single nucleotide polymorphisms in SMARCA4-LDLR gene locus (rs1122608, rs2228671, and rs688) and FVIII coagulant activity (FVIII:c) in subjects with (n = 692) or without (n = 291) angiographically confirmed coronary artery disease (CAD).
|
20810930 |
2010 |
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate 3 single nucleotide polymorphisms in SMARCA4-LDLR gene locus (rs1122608, rs2228671, and rs688) and FVIII coagulant activity (FVIII:c) in subjects with (n = 692) or without (n = 291) angiographically confirmed coronary artery disease (CAD).
|
20810930 |
2010 |
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results not only demonstrated potential interactions of APOE epsilon2/epsilon3/epsilon4 and LDLR C1773T polymorphisms with risk of having ischemic stroke, but also added the evidence of independent role of hypertension and APOE epsilon2/epsilon3/epsilon4 polymorphism in the development of this disorder in Northern Han Chinese.
|
18851860 |
2009 |
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Lastly, we evaluated whether rs688 associates with AD by genotyping DNA from 1457 men and 2055 women drawn from three case-control series.
|
18065781 |
2008 |