|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that carriers of rs6983267 GG in <i>CCAT2</i> were more susceptible to HCC, with the odds ratio (OR) and adjusted odds ratio (AOR) being 1.532 (95% CI, 1.103-2.129; <i>p</i> = 0.011) and 1.627 (95% CI, 1.120-2.265; <i>p</i> = 0.033), respectively.
|
31398859 |
2019 |
|
Rectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We confirmed that the homozygous T/T allele of rs6983267 c-MYC indicated an interaction between dietary seaweed intake and both overall CRC and rectal cancer (CRC OR [95% CI] = 0.52 [0.34-0.81], P for interaction = 0.015; rectal cancer = 0.45 [0.25-0.79], P for interaction = 0.007, T/T carriers with high total seaweed intake vs. T/T carriers with low total seaweed intake).
|
31300834 |
2019 |
|
Miscarriage
|
|
0.010 |
GeneticVariation
|
BEFREE |
The combined analysis of the two protective polymorphisms (rs3843549 AA and rs6983267 TG/GG) revealed that individuals with two unfavorable alleles exhibited a lower risk of recurrent miscarriage than those with no or only one unfavorable allele (adjusted OR = 0.531; 95% CI = 0.382-0.739).
|
30982978 |
2019 |
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, for rs6983267 on 8q24, the low risk allele is associated with a higher risk for recurrence and metastasis after surgery, and importantly, is strongly correlated with the resistance of CRC cell lines to chemoradiotherapy (CRT).
|
29119627 |
2018 |
|
Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs6983267 SNP may contribute to the increased MYC expression as well as the spread and rapid growth of cervical SCC as compared to lower grade carcinomas.
|
29525942 |
2018 |
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, the role of rs6983267 SNP in cervical cancer (CC) development and progression has not been demonstrated to date.
|
29525942 |
2018 |
|
cervical cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
The association of CCAT2 rs6983267 SNP with MYC expression and progression of uterine cervical cancer in the Polish population.
|
29525942 |
2018 |
|
Cervical Squamous Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs6983267 SNP may contribute to the increased MYC expression as well as the spread and rapid growth of cervical SCC as compared to lower grade carcinomas.
|
29525942 |
2018 |
|
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, the role of rs6983267 SNP in cervical cancer (CC) development and progression has not been demonstrated to date.
|
29525942 |
2018 |
|
Adenomatous Polyps
|
|
0.010 |
GeneticVariation
|
BEFREE |
Serum CCAT2 and HULC were upregulated in CRC and AP patients versus controls and discriminated these groups by ROC analysis. rs6983267 GG and rs7763881 AA patients demonstrated higher serum CCAT2 and HULC compared with GT/TT and AC, respectively. rs6983267 and serum HULC predicted CRC diagnosis among non-CRC groups (AP + controls) by multivariate analysis.
|
29176650 |
2017 |
|
Malignant neoplasm of ovary
|
|
0.010 |
GeneticVariation
|
BEFREE |
Summarily, this study suggested that 8q24 rs6983267 may contribute to the susceptibility of ovarian cancer in premenopausal Han Chinese women, supporting the pleiotropy of 8q24 in carcinogenesis.
|
28430593 |
2017 |
|
Carcinoma, Ovarian Epithelial
|
|
0.010 |
GeneticVariation
|
BEFREE |
Summarily, this study suggested that 8q24 rs6983267 may contribute to the susceptibility of ovarian cancer in premenopausal Han Chinese women, supporting the pleiotropy of 8q24 in carcinogenesis.
|
28430593 |
2017 |
|
Malignant neoplasm of gastrointestinal tract
|
|
0.010 |
GeneticVariation
|
BEFREE |
Meta-analysis of gastrointestinal cancer genetic analysis studies did not confirm an association between 8q24 chromosome polymorphisms (specifically rs6983267 and rs1447295) and susceptibility to GC in the general populations.
|
29232378 |
2017 |
|
ovarian neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Summarily, this study suggested that 8q24 rs6983267 may contribute to the susceptibility of ovarian cancer in premenopausal Han Chinese women, supporting the pleiotropy of 8q24 in carcinogenesis.
|
28430593 |
2017 |
|
Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Summarily, this study suggested that 8q24 rs6983267 may contribute to the susceptibility of ovarian cancer in premenopausal Han Chinese women, supporting the pleiotropy of 8q24 in carcinogenesis.
|
28430593 |
2017 |
|
Endometrial Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The expression of CARLo-5 was significantly correlated with the rs6983267 genotype associated with increased susceptibility to EC.Environ.Mol.Mutagen.57:508-515, 2016.© 2016 Wiley Periodicals, Inc.
|
27432114 |
2016 |
|
Secondary malignant neoplasm of lymph node
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was a significant correlation between the rs6983267 genotypes and lymph node metastasis of EC patients (P = 0.026).
|
27432114 |
2016 |
|
polyps
|
|
0.010 |
GeneticVariation
|
BEFREE |
No SNP was significantly associated with hyperplastic polyps, and only rs6983267 was significantly associated with sessile serrated polyps, but this association was opposite of that found in colorectal cancer GWAS.
|
24875374 |
2014 |
|
Alcohol or Other Drugs use
|
|
0.010 |
GeneticVariation
|
BEFREE |
We used meta-analysis of an efficient empirical-Bayes estimator to detect potential multiplicative interactions between each of the SNPs [rs16892766 at 8q23.3 (EIF3H/UTP23), rs6983267 at 8q24 (MYC), rs10795668 at 10p14 (FLJ3802842), rs3802842 at 11q23 (LOC120376), rs4444235 at 14q22.2 (BMP4), rs4779584 at 15q13 (GREM1), rs9929218 at 16q22.1 (CDH1), rs4939827 at 18q21 (SMAD7), rs10411210 at 19q13.1 (RHPN2), and rs961253 at 20p12.3 (BMP2)] and select major CRC risk factors (sex, body mass index, height, smoking status, aspirin/nonsteroidal anti-inflammatory drug use, alcohol use, and dietary intake of calcium, folate, red meat, processed meat, vegetables, fruit, and fiber).
|
22367214 |
2012 |
|
Intestinal Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors.
|
23118011 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
There is a robust risk of the minor G allele at the 8q24 rs6983267 SNP; however, a major T allele SNP could more clearly reveal a correlation with CRC specifically when DM is present.
|
22434246 |
2012 |
|
Metastatic Prostate Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
MSMB rs10993994 (per variant allele summary RR = 1.24, 95% CI = 1.05-1.48), 8q24 rs4242382 (RR = 1.40, 95% CI = 1.13-1.75), and 8q24 rs6983267 (RR = 0.67, 95% CI = 0.50-0.89) were associated with risk for metastatic prostate cancer.
|
21343373 |
2011 |
|
Primary differentiated carcinoma of thyroid gland
|
|
0.010 |
GeneticVariation
|
BEFREE |
The two SNPs that map at 8q24, rs6983267 and rs1447295, and the two TRHR polymorphisms showed no association with DTC.
|
21476894 |
2011 |
|
Differentiated Thyroid Gland Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The two SNPs that map at 8q24, rs6983267 and rs1447295, and the two TRHR polymorphisms showed no association with DTC.
|
21476894 |
2011 |
|
Metastasis from malignant tumor of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
MSMB rs10993994 (per variant allele summary RR = 1.24, 95% CI = 1.05-1.48), 8q24 rs4242382 (RR = 1.40, 95% CI = 1.13-1.75), and 8q24 rs6983267 (RR = 0.67, 95% CI = 0.50-0.89) were associated with risk for metastatic prostate cancer.
|
21343373 |
2011 |