|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings provide fundamental insights into the functional role of rs6983267 SNP and <i>CCAT2</i> in myeloid malignancies.
|
29567676 |
2018 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The pooled results showed that rs6983267 polymorphism was significantly associated with increased risk of overall cancer in all genetic models (dominant model: OR = 1.19, 95% CI = 1.13-1.26; recessive model: OR = 1.19, 95% CI = 1.14-1.25; homozygous model: OR= 1.31, 95% CI = 1.23-1.40; heterozygous model: OR = 1.14, 95% CI = 1.10-1.19; allelic model: OR = 1.14, 95% CI = 1.11-1.18).
|
28915683 |
2017 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we show that the long ncRNA CCAT2, located at the 8q24 amplicon on cancer risk-associated rs6983267 SNP, regulates cancer metabolism in vitro and in vivo in an allele-specific manner by binding the Cleavage Factor I (CFIm) complex with distinct affinities for the two subunits (CFIm25 and CFIm68).
|
26853146 |
2016 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (SNP) rs6983267 and cancer-associated region long non-coding RNA (CARLo-5) are associated with various human cancers.
|
27432114 |
2016 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphism rs6983267 from region 3 of the chromosome 8q24 appears to be a prominent risk factor for PCa and a biomarker for cancer aggressiveness in the group of patients who presented higher levels of PSA at the time of diagnosis.
|
24224612 |
2014 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Common variation rs6983267 at 8q24.1 and risk of colorectal adenoma and cancer: evidence based on 31 studies.
|
24375194 |
2014 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Heterogeneity was observed (P(heterogeneity) = 0.029) with rs6983267 and liver cancer, with positive association in the dominant model among those with a family history of cancer and positive association in the recessive model among those without a family history of cancer.
|
24030569 |
2014 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The expression of one of the long noncoding RNAs, CARLo-5, is significantly correlated with the rs6983267 allele associated with increased cancer susceptibility.
|
24594601 |
2014 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Six single-nucleotide polymorphisms within 8q24 were analyzed, previously associated with the risk of cancer (i.e., rs6983267, rs1447295, rs10808556, rs7000448, rs13254738, and rs13281615) in a population of 1,250 patients affected by DTC and 1,250 controls from Central and Southern Italy.
|
24008490 |
2013 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
No significant association was found among EGF -1380A/G, -1744G/A, rs6983267T/G polymorphisms and cancer risk.
|
22070650 |
2012 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The authors conducted a prostate cancer case-control study in the Greek population to evaluate the association of the single nucleotide polymorphism (SNP) rs6983267, located at region 3 of chromosome 8q24, with this type of cancer.
|
22070222 |
2011 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
We show that the beta-catenin-TCF4 transcription factor complex binds preferentially to the cancer risk-associated rs6983267(G) allele in colon cancer cells.
|
20065031 |
2010 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.
|
19561607 |
2009 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Four hundred and sixty-six GT heterozygotes identified in this study were analyzed for allelic imbalance at rs6983267 in the respective cancer DNA.
|
18172290 |
2008 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The strength of the association of the regional haplotype containing variant alleles at rs10808555, rs6983267 and rs7837328 but not rs10505476 was greater than that of any single variant of both adenoma (OR = 1.27, P = 0.0001) and cancer (OR = 1.26, P = 0.03).
|
18535017 |
2008 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine the range of cancer sites associated with rs6983267, we genotyped 7,665 cases of cancer, representing 11 common cancer sites, and 1,910 controls.
|
19047180 |
2008 |