|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of a genome-wide association study (GWAS) showed that two functional single-nucleotide polymorphisms (SNPs; rs699A>G and rs5050T>G) in the angiotensinogen (AGT) gene were related to cardiovascular disease susceptibility.
|
30719178 |
2019 |
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Angiotensinogen (AGT) M235T gene polymorphism is associated with risk of ischemic stroke and cardiovascular disease.
|
30409744 |
2019 |
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aims of the study were (i) to assess the distribution of the angiotensin II type 1 receptor (AGTR1) gene 1166A/C polymorphism and two polymorphisms of the angiotensinogen (AGT) gene (Met235Thr and Thr174Met) in patients with ST-segment-elevation myocardial infarction (STEMI) who underwent coronary angiography, compared with healthy volunteers; (ii) to determine if there was any correlation between these polymorphisms and risk of STEMI; and (iii) to assess the association of the examined polymorphisms with such classic cardiovascular risk factors as hypertension, diabetes mellitus, obesity (based on a body mass index ≥25 kg/m2), smoking, dyslipidemia, and family history of cardiovascular disease.
|
21657802 |
2011 |
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, A-T haplotype of G-6A and M235T interacting with homozygous ACE_II (beta=-1.07, P=0.006) and with ACE inhibitors (beta=-1.03, P=0.01) significantly decreased the risk of LEAD in white but not in black participants after adjustment for the selected CVD risk factors.
|
17429448 |
2007 |
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that in Slovak population, D alelle and M235T variant represent a risk factor for several cardiovascular diseases and these polymorphisms might have a cumulative effect on development of cardiovascular diseases.
|
17579251 |
2007 |
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, to detect any relationship between AGT M235T variation and intermediate and quantitative traits relevant to the pathogenesis of cardiovascular disease and PCOS, we looked for genotype-dependent differences within the subjects with PCOS.
|
16275260 |
2005 |
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE), the A1166C polymorphism in the angiotensin type 1 receptor (AT1R), and the M235T polymorphism of the angiotensinogen gene are associated with cardiovascular disease mostly in men.
|
16274774 |
2005 |
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate whether the M235T polymorphism in the angiotensinogen gene was associated with angiotensinogen levels, systolic and diastolic blood pressure, hypertension, and risk of ischemic cardiovascular disease in different ethnic populations.
|
12805070 |
2003 |
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The angiotensinogen M235T polymorphism has been linked to hypertension and cardiovascular disease.
|
12911327 |
2003 |
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The angiotensinogen M235T polymorphism has been linked to hypertension and cardiovascular disease.
|
11463770 |
2001 |
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study shows that genetic variation of the AGT (M235T), but not the ACE (I/D), genotypes contributes to the presence of CHD independently of blood pressure profile in a subset of the Spanish population with a high prevalence of cardiovascular disease.
|
11345362 |
2001 |
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several polymorphisms of genes encoding for components of the renin angiotensin system such as the M235T polymorphism in the angiotensinogen gene, the 287-base-pair insertion (I)/deletion (D) polymorphism at intron 16 of the ACE gene, and the A1166C polymorphism in the angiotensin II type 1 receptor gene have been associated with an increased risk of cardiovascular diseases.
|
10351920 |
1999 |
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The significant relations observed between the AGT M235T variant, its protein product, and the cardiovascular disease phenotypes provide evidence for a possible role of elevated circulating AGT in the pathogenesis of coronary artery disease.
|
10097233 |
1999 |
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
To assess the value of genotyping AGT in a genetically homogeneous population, we carried out a retrospective, case control study of variants M235T and T174M for putative correlations with CVDs among nationals from the United Arab Emirates (Emirati)--an ethnic group characterized by no alcohol intake and no cigarette smoking.
|
9831339 |
1998 |