rs699, AGT

N. diseases: 134
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Kidney Diseases
CUI: C0022658
Disease: Kidney Diseases
0.100 GeneticVariation BEFREE Genetic variants of ACE (Insertion/Deletion) and AGT (M268T) genes in patients with diabetes and nephropathy. 24737640 2014
Kidney Diseases
CUI: C0022658
Disease: Kidney Diseases
0.100 GeneticVariation BEFREE To assess the antiproteinuric response to multifactorial treatment based on high doses of angiotensin II receptor antagonists (ARBs) (olmesartan) in patients with non-diabetic proteinuric nephropathies, according to three renin-angiotensin system (RAS) polymorphisms: insertion/deletion of the angiotensin converting enzyme (ACE) gene, the angiotensinogen gene M235T and the angiotensin II type 1 receptor (AT1R) A1166C. 24241364 2013
Kidney Diseases
CUI: C0022658
Disease: Kidney Diseases
0.100 GeneticVariation BEFREE Association of the angiotensinogen M235T and APO E gene polymorphisms in Turkish type 2 diabetic patients with and without nephropathy. 21500980 2011
Kidney Diseases
CUI: C0022658
Disease: Kidney Diseases
0.100 GeneticVariation BEFREE ACE ID/DD genotypes in combination with ACE rs4311, rs4343, and AGT rs699 mutant genotypes increased the risk of DNP development fourfold (p < 0.01). 19108684 2009
Kidney Diseases
CUI: C0022658
Disease: Kidney Diseases
0.100 GeneticVariation BEFREE There were no differences in the frequencies of the AGT M235T and ACE I/D genotypes between Turkish patients with type 2 DM with and without nephropathy. 18413162 2008
Kidney Diseases
CUI: C0022658
Disease: Kidney Diseases
0.100 GeneticVariation BEFREE Three SNPs within the AGT, including M235T and one SNP in the AGTR1, were also significantly associated with nephropathy (M235T P=0.01, odds ratio =0.74, 95% CI 0.59-0.94). 17143591 2007
Kidney Diseases
CUI: C0022658
Disease: Kidney Diseases
0.100 GeneticVariation BEFREE The allele frequencies of AGT point mutation at 235 (M235T) was significantly higher in DM nephropathy but the genotypic frequencies were not. 12728975 2003
Kidney Diseases
CUI: C0022658
Disease: Kidney Diseases
0.100 GeneticVariation BEFREE The ACE-I/D polymorphism was shown to be a risk factor of progression of renal disease and the AGT-M235T polymorphism was associated with the severity of arterial hypertension. 14610337 2003
Kidney Diseases
CUI: C0022658
Disease: Kidney Diseases
0.100 GeneticVariation BEFREE Recently, the angiotensinogen (AGT) gene, M235T, and angiotensin II type 1 receptor (ATR) gene, A1166C, polymorphisms have been associated with the susceptibility to develop hypertension and renal disease. 12950120 2003
Kidney Diseases
CUI: C0022658
Disease: Kidney Diseases
0.100 GeneticVariation BEFREE The M235T polymorphism of the angiotensinogen gene (AGT) is associated with an increased risk of primary hypertension, which may then lead to progressive renal disease. 12164881 2002
Kidney Diseases
CUI: C0022658
Disease: Kidney Diseases
0.100 GeneticVariation BEFREE Our study provided evidence against an association between angiotensinogen M235T or chymase gene CMA/B polymorphisms and the presence of incipient or overt nephropathy in Caucasian patients with type II diabetes. 11096141 2000
Kidney Diseases
CUI: C0022658
Disease: Kidney Diseases
0.100 GeneticVariation BEFREE In this meta-analysis, we attempted to derive pooled estimates for the putative associations between various cardiovascular-renal disorders and the M235T polymorphism of the angiotensinogen gene. 10100088 1999
Kidney Diseases
CUI: C0022658
Disease: Kidney Diseases
0.100 GeneticVariation BEFREE We found that among males (but not females) the T allele of the M235T polymorphism was transmitted preferentially to those with nephropathy compared with IDDM patients without nephropathy (P=.05). 9461232 1998
Kidney Diseases
CUI: C0022658
Disease: Kidney Diseases
0.100 GeneticVariation BEFREE This study examined the association between the development of nephropathy in non-insulin-dependent diabetes mellitus (NIDDM) patients and M235T polymorphism in the angiotensinogen gene. 9535411 1998
Kidney Diseases
CUI: C0022658
Disease: Kidney Diseases
0.100 GeneticVariation BEFREE We conclude that the angiotensinogen polymorphism M235T might influence susceptibility to nephropathy in insulin-dependent diabetes, but its effect, if any, is rather small and independent of hypertension. 8621207 1996