rs699, AGT

N. diseases: 134
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE Our study suggests that M235T polymorphism might be a helpful biomarker for screening of susceptible individuals for MI in Asian population. 27586550 2016
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE Anterior wall infarction, increased leucocyte count, decreased longitudinal strain of left ventricular and polymorphism of AGT M235T may predict remodelling after myocardial infarction. 23283822 2014
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE This meta-analysis demonstrated that the AGT M235T polymorphism could be a prediction marker for risk of MI in Asians. 23283824 2014
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE In East Asian group, significant association was found between AGT M235T polymorphism and risk of MI (for dominant model: OR=1.79; 95% CI=1.04-3.06; for recessive model OR=2.01; 95% CI=1.21-3.36; for additive model OR=1.79; 95% CI=1.14-2.86) as well as BI (for dominant model: OR=1.66; 95% CI=1.22-2.27; for recessive model OR=1.78, 95% CI=1.29-2.46; for additive model: OR=1.64, 95% CI=1.34-2.00), while the M235T polymorphism did not impact the risk of MI in total population and other ethnicity. 23933419 2013
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE The direction of further research should focus not only on the simple relationshi</span>p of M235T polymorphism and MI risk, but also on gene-gene and gene-environment interaction. 23666149 2013
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE In Slovak population, M235T is associated with increased blood pressure and D allele of ACE gene is associated with MI, chronic CHD and DCM, rather than with hypertension. 17579251 2007
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE A significant drug-gene interaction was not found on the risk of stroke (SI: 1.83; 95% CI: 0.95-3.54) in ACE-inhibitor users or between current use of beta-blockers and the AGT M235T polymorphism on the risk of MI or stroke. 17299437 2007
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE We analyzed the independent contribution of the angiotensinogen M235T mutation to the development of recurrent coronary events (coronary-related death, nonfatal myocardial infarction, or unstable angina) in a cohort of 916 black (n=145) and white (n=771) postmyocardial infarction patients who were prospectively studied during an average follow-up of 28 months. 16940224 2006
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE The TT genotype of the AGT gene M235T polymorphism was associated with an increased risk of CHD and myocardial infarction only in smokers. 14502296 2003
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE M235T genotype did not predict systolic or diastolic blood pressure or risk of ischemic heart disease or myocardial infarction in either ethnic group. 12805070 2003
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE Angiotensinogen Met235Thr polymorphism, angiotensin-converting enzyme inhibitor therapy, and the risk of nonfatal stroke or myocardial infarction in hypertensive patients. 14643574 2003
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE Both alleles of the M235T polymorphism of the angiotensinogen gene can be a risk factor for myocardial infarction. 11531970 2001
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE To determine whether the DNA polymorphisms in A:POE (epsilon2, epsilon3, and epsilon4 alleles), A:GT (M235T), A:T1R (1166 A:/C:), and ACE (I:/D:) are associated with early onset of myocardial infarction (MI), we genotyped 220 patients and 200 controls <55 years of age. 11106322 2000
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE To explore the role of the angiotensinogen (AGT) gene in coronary atherosclerosis and thrombosis, we studied the effect of the AGT M235T gene variant on plasma AGT levels and BP in patients with coronary artery disease and in the subgroup of survivors of myocardial infarction as compared with angiographically defined control subjects. 10097233 1999
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE The relative frequencies of the T and M alleles of the T174M and of the M235T gene variation did not significantly differ between patients without or with single-, double- or triple-vessel disease and between subjects without or with myocardial infarction (MI). 10488958 1999
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE We analyzed the evolution with age of the frequencies of the I/D polymorphism of the angiotensin I-converting enzyme (ACE), a1166c of the angiotensin II AT1 receptor (AT1R), M235T of the angiotensinogen (AGT) and A225V of their methylenetetrahydrofolate reductase (MTHFR) gene in a healthy (H) population and the subsequent comparison to age- and sex-matched groups of myocardial infarction (MI) subjects. 10488956 1999
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE This case-control study was initiated to investigate whether the ACEI/D and AGT M235T polymorphisms are associated with an increased risk for coronary heart disease (CHD) and MI. 9034401 1997
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE The purpose of the present study was to assess whether the insertion (I)/deletion (D) polymorphism of the angiotensin converting enzyme (ACE) gene, and the polymorphism of angiotensinogen (AGT) gene with threonine (T) instead of methionine (M) at amino acid 235 in exon 2 (M235T) were associated with left ventricular dilatation after myocardial infarction. 8793580 1996
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE The T174M and M235T genotype distributions did not differ between survivors of myocardial infarction and controls. 7622852 1995
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE The angiotensinogen-TT genotype (T indicates threonine instead of methionine at position 235) was more frequent in the myocardial infarction group than in the control group (P < .05). 7737732 1995