rs699, AGT

N. diseases: 134
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE The M235T variant of the AGT is significantly associated with female hypertensives and ACE DD variant could be a risk allele for essential hypertension in south India. 24860821 2014
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE Gender-related association of AGT gene variants (M235T and T174M) with essential hypertension--a case-control study. 22148914 2012
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE Strong epistatic interactions were found between -6G>A, M235T and -217G>A markers, supporting the synergistic effect between them leading to EHT. 22570327 2012
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE We studied the effects of the angiotensinogen M235T, angiotensin converting enzyme insertion/deletion (ACE I/D), and angiotensin II receptor 1 (AT1R) A1166C gene polymorphisms on the risk of HTA and to evaluate the relationship between these polymorphisms and obesity. 21779803 2012
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE We determined the association of angiotensinogen (M235T) gene polymorphism with essential hypertension and the relationship between polymorphism in the angiotensinogen (M235T) gene and blood pressure response to ACE inhibitor (Enalapril) in patients with essential hypertension from northern Indian subjects. 22974788 2012
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE Association between the M268T polymorphism in the angiotensinogen gene and essential hypertension in a South Indian population. 21312059 2011
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE The present meta-analysis suggests that AGT M235T and ACE I/D modulate the risk of essential hypertension in Han Chinese population. 20087216 2010
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE Renin gene I/D polymorphism is associated with EH, whereas AGT gene M235T, A-6G, and A-20C polymorphisms and the haplotypes are not associated with EH in the Mongolian population. 20662730 2010
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE Meta-analysis of the association of 4 angiotensinogen polymorphisms with essential hypertension: a role beyond M235T? 18227406 2008
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE Several studies in different populations link Threonine instead of methionine at position 235 (M235T) and Methinine instead of threonine at position 174 (T174M) polymorphisms with essential hypertension. 18404605 2008
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE Our single-locus analysis revealed that except for a marginal, significant association of A-20C allele distribution, no significant association between genotype and allele distributions of the A-20C, A-6G, or M235T polymorphism of AGT and essential hypertension was found. 18250562 2007
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE Although polymorphisms in renin-angiotensin-aldosterone (RAA) system genes for angiotensinogen (AGT M235T), angiotensin-converting enzyme (ACE I/D), angiotensin II type 1 receptor (AT1 A/C1166), and aldosterone synthase (CYP11B2-344T/C) have been major targets for genetic investigation in association with essential hypertension (EH), the influence of these genetic factors is still to be determined. 17190732 2007
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE The M235T mutation of the human angiotensinogen gene has been shown to be associated with elevated circulating angiotensinogen concentrations and essential hypertension. 16940224 2006
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE We investigated if renin-angiotensinaldosterone system associated genotypes (angiotensinogen [M235T] and ACE [I/D]) are related to blood pressure (BP), renal haemodynamics and sodium excretion in sex and age-matched (1835 years) healthy Caucasian offspring of either two parents with EH (n=101, EH-offspring) or two normotensive parents (n=50, controls). 17083073 2006
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE Angiotensinogen M235T gene variants and its association with essential hypertension and plasma renin activity in Malaysian subjects: a case control study. 15811183 2005
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE To determine whether carotid artery stiffness was increased in patients with untreated essential hypertension who are homozygous for the T allele of the M235T polymorphism of the angiotensinogen (AGT) gene and in mutant mice carrying three copies of the angiotensinogen (Agt) gene. 15201545 2004
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE The results of our study suggest an association of the M235T polymorphism in the gene encoding angiotensinogen with essential hypertension. 12169209 2003
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE In this study, we examined the role of AGT promoter polymorphisms, including G-217A, A-6G and M235T variants, and their promoter function in essential hypertension in Taiwanese populations. 14597849 2003
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE The angiotensinogen (AGT) gene polymorphism M235T (a methionine to threonine amino acid substitution) has been investigated in association with essential hypertension (EHT) based on conventional measurement of blood pressure (BP); however, the results have been inconsistent. 12661912 2003
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE In addition, the T235M polymorphism in the AGT product is associated with an increased risk of essential hypertension in multiple populations, making AGT a good example of a quantitative-trait locus underlying susceptibility to a common disease. 11731937 2002
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE The M235T polymorphism of the angiotensinogen gene (AGT) is associated with an increased risk of primary hypertension, which may then lead to progressive renal disease. 12164881 2002
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE An association of BMI with A (-6) G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension. 12037699 2002
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE A common variant at codon 235 of the angiotensinogen gene with methionine to threonine amino acid substitution (AGT M235T) has been reported as a genetic risk for essential hypertension. 11230286 2001
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE The ACE (I/D) polymorphism showed no association with CHD, whereas the frequency distribution of AGT (M235T) genotypes among patients and controls (235T: 29.1% and 19.0%; M235T: 48.5% and 50.2%; M235: 22.4% and 30.8%, respectively) was statistically different (p = 0.005) and not related to the presence of essential hypertension. 11345362 2001
Essential Hypertension
CUI: C0085580
Disease: Essential Hypertension
0.100 GeneticVariation BEFREE According to combined haplotype analysis of diallele and microsatellite markers, it remains a possibility that M235T, T+31C, G-6A, A-20C and G-1074T polymorphisms may play an important role in increased risk for essential hypertension. 11191642 2000