Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The M235T variant of the AGT is significantly associated with female hypertensives and ACE DD variant could be a risk allele for essential hypertension in south India.
|
24860821 |
2014 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Gender-related association of AGT gene variants (M235T and T174M) with essential hypertension--a case-control study.
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22148914 |
2012 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Strong epistatic interactions were found between -6G>A, M235T and -217G>A markers, supporting the synergistic effect between them leading to EHT.
|
22570327 |
2012 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied the effects of the angiotensinogen M235T, angiotensin converting enzyme insertion/deletion (ACE I/D), and angiotensin II receptor 1 (AT1R) A1166C gene polymorphisms on the risk of HTA and to evaluate the relationship between these polymorphisms and obesity.
|
21779803 |
2012 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
We determined the association of angiotensinogen (M235T) gene polymorphism with essential hypertension and the relationship between polymorphism in the angiotensinogen (M235T) gene and blood pressure response to ACE inhibitor (Enalapril) in patients with essential hypertension from northern Indian subjects.
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22974788 |
2012 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between the M268T polymorphism in the angiotensinogen gene and essential hypertension in a South Indian population.
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21312059 |
2011 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present meta-analysis suggests that AGT M235T and ACE I/D modulate the risk of essential hypertension in Han Chinese population.
|
20087216 |
2010 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Renin gene I/D polymorphism is associated with EH, whereas AGT gene M235T, A-6G, and A-20C polymorphisms and the haplotypes are not associated with EH in the Mongolian population.
|
20662730 |
2010 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis of the association of 4 angiotensinogen polymorphisms with essential hypertension: a role beyond M235T?
|
18227406 |
2008 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several studies in different populations link Threonine instead of methionine at position 235 (M235T) and Methinine instead of threonine at position 174 (T174M) polymorphisms with essential hypertension.
|
18404605 |
2008 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our single-locus analysis revealed that except for a marginal, significant association of A-20C allele distribution, no significant association between genotype and allele distributions of the A-20C, A-6G, or M235T polymorphism of AGT and essential hypertension was found.
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18250562 |
2007 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although polymorphisms in renin-angiotensin-aldosterone (RAA) system genes for angiotensinogen (AGT M235T), angiotensin-converting enzyme (ACE I/D), angiotensin II type 1 receptor (AT1 A/C1166), and aldosterone synthase (CYP11B2-344T/C) have been major targets for genetic investigation in association with essential hypertension (EH), the influence of these genetic factors is still to be determined.
|
17190732 |
2007 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The M235T mutation of the human angiotensinogen gene has been shown to be associated with elevated circulating angiotensinogen concentrations and essential hypertension.
|
16940224 |
2006 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated if renin-angiotensinaldosterone system associated genotypes (angiotensinogen [M235T] and ACE [I/D]) are related to blood pressure (BP), renal haemodynamics and sodium excretion in sex and age-matched (1835 years) healthy Caucasian offspring of either two parents with EH (n=101, EH-offspring) or two normotensive parents (n=50, controls).
|
17083073 |
2006 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Angiotensinogen M235T gene variants and its association with essential hypertension and plasma renin activity in Malaysian subjects: a case control study.
|
15811183 |
2005 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine whether carotid artery stiffness was increased in patients with untreated essential hypertension who are homozygous for the T allele of the M235T polymorphism of the angiotensinogen (AGT) gene and in mutant mice carrying three copies of the angiotensinogen (Agt) gene.
|
15201545 |
2004 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of our study suggest an association of the M235T polymorphism in the gene encoding angiotensinogen with essential hypertension.
|
12169209 |
2003 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we examined the role of AGT promoter polymorphisms, including G-217A, A-6G and M235T variants, and their promoter function in essential hypertension in Taiwanese populations.
|
14597849 |
2003 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The angiotensinogen (AGT) gene polymorphism M235T (a methionine to threonine amino acid substitution) has been investigated in association with essential hypertension (EHT) based on conventional measurement of blood pressure (BP); however, the results have been inconsistent.
|
12661912 |
2003 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, the T235M polymorphism in the AGT product is associated with an increased risk of essential hypertension in multiple populations, making AGT a good example of a quantitative-trait locus underlying susceptibility to a common disease.
|
11731937 |
2002 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The M235T polymorphism of the angiotensinogen gene (AGT) is associated with an increased risk of primary hypertension, which may then lead to progressive renal disease.
|
12164881 |
2002 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
An association of BMI with A (-6) G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension.
|
12037699 |
2002 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common variant at codon 235 of the angiotensinogen gene with methionine to threonine amino acid substitution (AGT M235T) has been reported as a genetic risk for essential hypertension.
|
11230286 |
2001 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ACE (I/D) polymorphism showed no association with CHD, whereas the frequency distribution of AGT (M235T) genotypes among patients and controls (235T: 29.1% and 19.0%; M235T: 48.5% and 50.2%; M235: 22.4% and 30.8%, respectively) was statistically different (p = 0.005) and not related to the presence of essential hypertension.
|
11345362 |
2001 |
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
According to combined haplotype analysis of diallele and microsatellite markers, it remains a possibility that M235T, T+31C, G-6A, A-20C and G-1074T polymorphisms may play an important role in increased risk for essential hypertension.
|
11191642 |
2000 |