|
Diabetic Retinopathy
|
|
0.060 |
GeneticVariation
|
BEFREE |
The VEGF gene SNPs analyzed with regard to DR susceptibility were rs2010963 (G > C), rs833061 (T > C), rs699947 (C > A), rs3025039 (C > T) and rs1570360 (G > A).
|
27613596 |
2017 |
|
Diabetic Retinopathy
|
|
0.060 |
GeneticVariation
|
BEFREE |
After adjustment for covariates, significant association of DR remained with the homozygous genotype of the minor allele for the SNPs rs699947 (odds ratio [OR] = 3.54, 95% confidence interval [CI]: 1.12-11.19), rs833061 (OR = 3.72, 95% CI: 1.17-11.85), rs13207351 (OR = 3.76, 95% CI: 1.21-11.71), and rs2146323 (OR = 2.8, 95% CI: 1.46-5.37) in the VEGF gene as well as the SNP rs2071559 (OR = 1.62, 95% CI: 1.08-2.41) in the KDR gene.
|
24623964 |
2014 |
|
Diabetic Retinopathy
|
|
0.060 |
GeneticVariation
|
BEFREE |
No evidence of association was observed between -2578 A/C (rs699947), +405C/G (rs2010963), +936C/T (rs3025039), and DR risk under stringent Bonferroni's correction.
|
24534217 |
2014 |
|
Diabetic Retinopathy
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our meta-analysis confirmed the significant association between rs699947 polymorphism and DR after exclusion of outliers, and rs2010963 polymorphism might be not associated with DR.
|
24131746 |
2013 |
|
Diabetic Retinopathy
|
|
0.060 |
GeneticVariation
|
BEFREE |
After adjusting for covariates, a significant association of DR was observed with the homozygous genotype of the minor allele for promoter SNPs rs699947 (odds ratio (OR)=3.54, 95% confidence interval (CI): 1.12-11.19), rs833061 (OR=3.72, 95% CI: 1.17-11.85) and rs13207351 (OR=3.76, 95% CI: 1.21-11.71).
|
22162628 |
2011 |
|
Diabetic Retinopathy
|
|
0.060 |
GeneticVariation
|
BEFREE |
We found a significant association between the A allele at rs699947 with DR (odds ratio = 1.84 (95% confidence interval = 1.28-2.66); P = 0.001 vs. noDR).
|
20444917 |
2010 |
|
Coronary Artery Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
In addition, stratification by control source indicated an increased risk of CAD susceptibility with the rs699947 polymorphism for population-based studies of reduced heterogeneity.
|
29973139 |
2018 |
|
Coronary heart disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our overall and subgroup analyses suggested that rs699947 polymorphism was significantly associated with CHD susceptibility in both Caucasians and Asians, rs1570360 polymorphism was significantly associated with CHD susceptibility in Caucasians, and rs3025039 polymorphism was significantly associated with CHD susceptibility in Asians.
|
30317903 |
2018 |
|
Coronary heart disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
In conclusion, our findings suggest that VEGFA rs699947 C>A, rs3025039 C>T and rs2010963 G>C polymorphisms are risk factors for CHD.
|
28430629 |
2017 |
|
Coronary Artery Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
We were unable to find strong association between analyzed polymorphisms in growth factors and the severity of coronary artery disease, although there was a trend toward association between rs699947 and the severity of CAD in patients without previous MI.
|
27835972 |
2016 |
|
Coronary heart disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms on VEGF (rs699947) and KDR (rs2305948and rs1870377), as well as relevant haplotypes, may serve as genetic markers that might be useful in future investigations on the pathogenesis of CHD.
|
26726843 |
2016 |
|
Coronary heart disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
All of the combined effects of rs699947 (CC/CA) and rs2305948 (TT), rs3025039 (TT) and rs2305948 (TT), rs3025039 (CT) and rs1870377 (AA) had positive effects on the risk of CHD, respectively (all P < 0.05).
|
27175642 |
2016 |
|
Coronary heart disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
We were unable to find strong association between analyzed polymorphisms in growth factors and the severity of coronary artery disease, although there was a trend toward association between rs699947 and the severity of CAD in patients without previous MI.
|
27835972 |
2016 |
|
Coronary Artery Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
The possible association of rs699947 and rs2010963 with CAD risks warrant confirmation in independent case-control studies and may be informative for future investigations on the pathogenesis of CAD.
|
23545315 |
2013 |
|
Coronary Artery Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
Logistic regression analyses revealed that the VEGFA rs699947 C/A, VEGFA rs2010963 G/C, and VEGFA rs3025039 C/T polymorphisms were not associated with a risk of CAD.
|
23880405 |
2013 |
|
Coronary Artery Disease
|
|
0.050 |
GeneticVariation
|
BEFREE |
This study tested the association between functional VEGF +405 C>G (rs2010963), -2578C>A (rs699947) polymorphisms, and coronary collaterals in patients with coronary artery disease (CAD).
|
20621071 |
2010 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
And VEGF-rs699947 polymorphism was also identified an increased risk of renal cell carcinoma (RCC) in allelic, heterozygote, dominant, homozygote, and recessive models.
|
29942264 |
2018 |
|
Renal Cell Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
In summary, our study showed evidence that the VEGF rs699947 polymorphism was obviously associated with an increased risk of bladder cancer and renal cell carcinoma, particularly in Asian population, while no significant association was observed in overall urologic neoplasms.
|
30195633 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
In summary, our study showed evidence that the VEGF rs699947 polymorphism was obviously associated with an increased risk of bladder cancer and renal cell carcinoma, particularly in Asian population, while no significant association was observed in overall urologic neoplasms.
|
30195633 |
2018 |
|
Renal Cell Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
And VEGF-rs69</span>9947 polymorphism was also identified an increased risk of renal cell carcinoma (RCC) in allelic, heterozygote, dominant, homozygote, and recessive models.
|
29942264 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The pooled OR indicated that rs699947 polymorphism was significantly associated with RCC risk in all genetic models.
|
28356760 |
2017 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that there may be a relationship between the VEGF rs2010963, rs3025039 and rs699947 polymorphisms and RCC susceptibility.
|
28562357 |
2017 |
|
Renal Cell Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The pooled OR indicated that rs699947 polymorphism was significantly associated with RCC risk in all genetic models.
|
28356760 |
2017 |
|
Renal Cell Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that there may be a relationship between the VEGF rs2010963, rs3025039 and rs699947 polymorphisms and RCC susceptibility.
|
28562357 |
2017 |
|
Bladder Neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
As to ethnicity subgroup analysis, rs699947 and rs3025039 polymorphisms were thought as a risk factor for BCa risk in Asian population, while a decreased association was revealed between rs699947 (C > A) A-allele and BCa risk in African population under dominant, recessive, homozygous, heterozygous and allele contrast genetic models.
|
30849545 |
2019 |