THYROID CANCER, NONMEDULLARY, 5
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0.700 |
GeneticVariation
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UNIPROT |
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Venous Thromboembolism
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0.010 |
GeneticVariation
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BEFREE |
Whether a single nucleotide polymorphism (1601 G > A) in the factor VII-activating protease gene (FSAP Marburg I) is a risk factor for venous thromboembolism (VTE) is unclear.
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16543963 |
2006 |
Cardiovascular Diseases
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0.010 |
GeneticVariation
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BEFREE |
The G534E polymorphism (Marburg I [MI]) of factor VII-activating protease (FSAP) is associated with carotid stenosis and cardiovascular disease.
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17145954 |
2006 |
Carotid Stenosis
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0.010 |
GeneticVariation
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BEFREE |
The G534E polymorphism (Marburg I [MI]) of factor VII-activating protease (FSAP) is associated with carotid stenosis and cardiovascular disease.
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17145954 |
2006 |
Atherothrombosis
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0.010 |
GeneticVariation
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BEFREE |
In clinical studies, the G534E single nucleotide polymorphism (Marburg I) of FSAP has been linked to late complications of atherothrombosis and is associated with a low proteolytic activity, particularly, towards pro-uPA.
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18278176 |
2008 |
Deep Vein Thrombosis
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0.010 |
GeneticVariation
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BEFREE |
We studied the association between the 1601G/A polymorphism, FSAP activity, FSAP antigen, Factor VIIa (FVIIa), prothrombin fragment 1+2 (F1+2), and C-reactive protein (CRP) in plasmas of 170 patients suspected for DVT.
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18394684 |
2008 |
Fibrosis, Liver
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0.030 |
GeneticVariation
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BEFREE |
The G534E variant of FSAP is a risk locus for HCV-induced liver fibrosis and cirrhosis by determining PDGF-BB-mediated hepatic stellate cell proliferation through a single amino acid substitution in FSAP.
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19105210 |
2009 |
Liver Cirrhosis
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0.010 |
GeneticVariation
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BEFREE |
The G534E variant of FSAP is a risk locus for HCV-induced liver fibrosis and cirrhosis by determining PDGF-BB-mediated hepatic stellate cell proliferation through a single amino acid substitution in FSAP.
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19105210 |
2009 |
Cirrhosis
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0.010 |
GeneticVariation
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BEFREE |
The G534E variant of FSAP is a risk locus for HCV-induced liver fibrosis and cirrhosis by determining PDGF-BB-mediated hepatic stellate cell proliferation through a single amino acid substitution in FSAP.
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19105210 |
2009 |
Diabetes
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0.010 |
GeneticVariation
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BEFREE |
Here, we demonstrate that a coding polymorphism (G534E) in the gene for FSAP is significantly associated with severe HCV-induced liver fibrosis (odds ratio, 2.59; P = 0.017), which is independent of age, gender, and presence of diabetes in multivariate analysis.
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19105210 |
2009 |
Hepatitis C
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0.010 |
GeneticVariation
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BEFREE |
FSAP G534</span>E might be useful for risk stratification in patients with HCV infection.
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19105210 |
2009 |
Diabetes Mellitus
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0.010 |
GeneticVariation
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BEFREE |
Here, we demonstrate that a coding polymorphism (G534E) in the gene for FSAP is significantly associated with severe HCV-induced liver fibrosis (odds ratio, 2.59; P = 0.017), which is independent of age, gender, and presence of diabetes in multivariate analysis.
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19105210 |
2009 |
Fibrosis, Liver
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0.030 |
GeneticVariation
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BEFREE |
A single nucleotide polymorphism (G534E, Marburg I, MI-SNP) in the gene encoding FSAP (HABP2) leads to lower enzymatic activity and is associated with enhanced liver fibrosis in humans.
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22989567 |
2013 |
Papillary thyroid carcinoma
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0.040 |
GeneticVariation
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BEFREE |
The HABP2 G534E variant (rs7080536) was genotyped in blood DNA from 179 PTC families (one affected individual per family), 1160 sporadic PTC cases and 1395 controls.
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26745718 |
2016 |
Thyroid Neoplasm
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0.040 |
GeneticVariation
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BEFREE |
These results are consistent with HABP2 G534E being a susceptibility gene in a subgroup of FNMTC, providing important diagnostic implications for this hereditary thyroid cancer.
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26832773 |
2016 |
Familial Nonmedullary Thyroid Gland Carcinoma
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0.040 |
GeneticVariation
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BEFREE |
These results are consistent with HABP2 G534E being a susceptibility gene in a subgroup of FNMTC, providing important diagnostic implications for this hereditary thyroid cancer.
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26832773 |
2016 |
Malignant neoplasm of thyroid
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0.040 |
GeneticVariation
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BEFREE |
These results are consistent with HABP2 G534E being a susceptibility gene in a subgroup of FNMTC, providing important diagnostic implications for this hereditary thyroid cancer.
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26832773 |
2016 |
Papillary thyroid carcinoma
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0.040 |
GeneticVariation
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BEFREE |
The overall prevalence of HABP2 G534E was six per 43 (14.0%) PTC patients from the 29 kindreds and four per 29 (13.8%) kindreds.
|
26832773 |
2016 |
Thyroid carcinoma
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0.040 |
GeneticVariation
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BEFREE |
These results are consistent with HABP2 G534E being a susceptibility gene in a subgroup of FNMTC, providing important diagnostic implications for this hereditary thyroid cancer.
|
26832773 |
2016 |
Familial Nonmedullary Thyroid Cancer
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0.020 |
GeneticVariation
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BEFREE |
HABP2 G534E Mutation in Familial Nonmedullary Thyroid Cancer.
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26832773 |
2016 |
Malignant neoplasm of thyroid
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0.040 |
GeneticVariation
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BEFREE |
The G534E variant has also been reported to occur in about 4.7% of cases of the Thyroid Cancer Genome Atlas (TCGA) database.
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26906432 |
2016 |
Thyroid carcinoma
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|
0.040 |
GeneticVariation
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BEFREE |
The G534E variant has also been reported to occur in about 4.7% of cases of the Thyroid Cancer Genome Atlas (TCGA) database.
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26906432 |
2016 |
Thyroid Neoplasm
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|
0.040 |
GeneticVariation
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BEFREE |
The G534E variant has also been reported to occur in about 4.7% of cases of the Thyroid Cancer Genome Atlas (TCGA) database.
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26906432 |
2016 |
Thyroid Diseases
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0.010 |
GeneticVariation
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BEFREE |
As a control cohort, 190 healthy individuals without known thyroid disease were also studied for the presence of the G534E variant using DNA isolated from peripheral leucocytes.
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26906432 |
2016 |
Fibrosis, Liver
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0.030 |
GeneticVariation
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BEFREE |
A single nucleotide polymorphism (G534E) in HABP2 leads to lower enzymatic activity and is associated with enhanced liver fibrosis in humans.
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27462075 |
2016 |