rs7105934, LOC102724265

N. diseases: 5
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Renal Cell Carcinoma
CUI: C0007134
Disease: Renal Cell Carcinoma
0.830 GeneticVariation GWASDB Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3. 21131975 2011
Renal Cell Carcinoma
CUI: C0007134
Disease: Renal Cell Carcinoma
0.830 GeneticVariation GWASCAT Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3. 21131975 2011
Renal Cell Carcinoma
CUI: C0007134
Disease: Renal Cell Carcinoma
0.830 GeneticVariation GWASDB A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23. 22010048 2012
Renal Cell Carcinoma
CUI: C0007134
Disease: Renal Cell Carcinoma
0.830 GeneticVariation BEFREE No significant association between rs7579899 or rs7105934 and RCC risk was observed. 22131124 2012
Conventional (Clear Cell) Renal Cell Carcinoma
0.030 GeneticVariation BEFREE No significant association between rs7579899 or rs7105934 and RCC risk was observed. 22131124 2012
Renal Cell Carcinoma
CUI: C0007134
Disease: Renal Cell Carcinoma
0.830 GeneticVariation BEFREE After adjusting for patient age, gender, smoking status and body mass index the AG + AA genotypes from rs7105934 (11q13) were associated with a decreased risk of renal cell carcinoma (OR 0.50, 95% CI 0.33-0.75, p = 0.001) and the AC + CC genotypes from rs1049380 (ITPR2) were associated with an increased risk (OR 1.66, 95% CI 1.28-2.16, p <0.001). 23911636 2014
Renal Cell Carcinoma
CUI: C0007134
Disease: Renal Cell Carcinoma
0.830 GeneticVariation BEFREE This study provides, to our knowledge, the first evidence that r</span>s7105934 is an RCC susceptibility locus among AAs. 24220910 2014
Conventional (Clear Cell) Renal Cell Carcinoma
0.030 GeneticVariation BEFREE After adjusting for patient age, gender, smoking status and body mass index the AG + AA genotypes from rs7105934 (11q13) were associated with a decreased risk of renal cell carcinoma (OR 0.50, 95% CI 0.33-0.75, p = 0.001) and the AC + CC genotypes from rs1049380 (ITPR2) were associated with an increased risk (OR 1.66, 95% CI 1.28-2.16, p <0.001). 23911636 2014
Conventional (Clear Cell) Renal Cell Carcinoma
0.030 GeneticVariation BEFREE This study provides, to our knowledge, the first evidence that r</span>s7105934 is an RCC susceptibility locus among AAs. 24220910 2014
Malignant neoplasm of kidney
CUI: C0740457
Disease: Malignant neoplasm of kidney
0.010 GeneticVariation BEFREE Kidney cancer developed at an older age in patients carrying the dominant risk allele A for rs7105934 (mean age at diagnosis 73.1 vs 68.9 years, p = 0.002) and at a younger age in those carrying the dominant allele C for rs1049380 (mean 68.1 vs 70.8 years, p = 0.005). 23911636 2014
Renal carcinoma
CUI: C1378703
Disease: Renal carcinoma
0.010 GeneticVariation BEFREE Kidney cancer developed at an older age in patients carrying the dominant risk allele A for rs7105934 (mean age at diagnosis 73.1 vs 68.9 years, p = 0.002) and at a younger age in those carrying the dominant allele C for rs1049380 (mean 68.1 vs 70.8 years, p = 0.005). 23911636 2014
Clear-cell metastatic renal cell carcinoma
0.010 GeneticVariation BEFREE The rs7105934 association was stronger for clear cell RCC (ccRCC: OR, 0.56; P = 7.4 × 10(-7)) and absent for cases of other or unknown histology (OR, 1.02; P = 0.86). 24220910 2014
Renal Cell Carcinoma
CUI: C0007134
Disease: Renal Cell Carcinoma
0.830 GeneticVariation GWASCAT Genome-wide association study identifies multiple risk loci for renal cell carcinoma. 28598434 2017
Renal Cell Carcinoma
CUI: C0007134
Disease: Renal Cell Carcinoma
0.830 GeneticVariation GWASCAT Sex specific associations in genome wide association analysis of renal cell carcinoma. 31231134 2019