|
Atrial Fibrillation
|
|
0.870 |
GeneticVariation
|
BEFREE |
Rs13376333 on chromosome 1q21 (in KCNN3), rs7193343 and rs2106261 on chromosome 16q22 (in ZFHX3) were not associated with AF recurrence in our meta-analysis.
|
31169720 |
2019 |
|
Atrial Fibrillation
|
|
0.870 |
GeneticVariation
|
BEFREE |
Common single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (rs2200733, rs10033464 near PITX2), 1q21 (rs13376333 in KCNN3), and 16q22 (rs7193343 in ZFHX3) have consistently been associated with the risk of atrial fibrillation (AF).
|
25684755 |
2015 |
|
Atrial Fibrillation
|
|
0.870 |
GeneticVariation
|
BEFREE |
In Caucasian population, genetic variant rs7193343 SNP is associated with risk of AF in Caucasian population.
|
26112950 |
2015 |
|
Atrial Fibrillation
|
|
0.870 |
GeneticVariation
|
BEFREE |
Variants rs2200733 and rs7193343 are associated with a higher risk of atrial fibrillation.
|
25262128 |
2014 |
|
Atrial Fibrillation
|
|
0.870 |
GeneticVariation
|
BEFREE |
All the polymorphisms tested (except rs17570669) correlated significantly with AF in univariate analysis (p values between 0.039 for rs7193343 and 2.7e-27 for rs2200733), with the odds ratio (OR) 0.572 and 0.617 for rs3853445 and rs6838973, respectively (protective role) and OR 1.268 to 3.52 for the other polymorphisms.
|
21760908 |
2011 |
|
Atrial Fibrillation
|
|
0.870 |
GeneticVariation
|
BEFREE |
Recent genome-wide association studies (GWAS) identified two single nucleotide polymorphisms (SNPs), rs2106261 and rs7193343 in ZFHX3 (zinc finger homeobox 3 gene) and rs13376333 in KCNN3 (encoding a potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3) that showed significant association with AF in multiple populations of European ancestry.
|
21107608 |
2011 |
|
Atrial Fibrillation
|
|
0.870 |
GeneticVariation
|
BEFREE |
A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)).
|
19597491 |
2009 |
|
Atrial Fibrillation
|
|
0.870 |
GeneticVariation
|
GWASDB |
A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)).
|
19597491 |
2009 |
|
Atrial Fibrillation
|
|
0.870 |
GeneticVariation
|
GWASCAT |
A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)).
|
19597491 |
2009 |
|
Ischemic stroke
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study.
|
26708676 |
2016 |
|
Ischemic stroke
|
|
0.710 |
GeneticVariation
|
BEFREE |
Nonparametric linkage analysis revealed that the rs1800796 polymorphism in the interleukin-6 (IL-6) gene is significantly linked to the small arterial occlusion (SAO) subtype (p=0.022), while the rs7193343 polymorphism in the ZFHX3 gene is linked to IS (p=0.002) under the dominant model.
|
25325233 |
2014 |
|
Cardiac embolism
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study.
|
26708676 |
2016 |