Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Irritable Bowel Syndrome
CUI: C0022104
Disease: Irritable Bowel Syndrome
0.030 GeneticVariation BEFREE Previously, we reported that a CRHR1 gene polymorphism (rs110402, rs242924, and rs7209436) and haplotypes were associated with IBS. 26808377 2016
Irritable Bowel Syndrome
CUI: C0022104
Disease: Irritable Bowel Syndrome
0.030 GeneticVariation BEFREE Three CRH-R1 SNPS (rs110402, rs242924, and rs7209436) were genotyped using salivary DNA from IBS and healthy control subjects (HCs). 27497153 2016
Irritable Bowel Syndrome
CUI: C0022104
Disease: Irritable Bowel Syndrome
0.030 GeneticVariation BEFREE The TT genotype of rs7209436 (P = 0.01) and rs242924 (P = 0.02) was significantly more common in patients with IBS than in controls. 22957021 2012
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.010 GeneticVariation BEFREE We observed interactions between trait anxiety and rs7209436 and rs110402 in CRHR1 in association with baseline cortisol (p LRT = 0.0272 and p LRT = 0.0483, respectively). 23274505 2013
Anxiety
CUI: C0003467
Disease: Anxiety
0.010 GeneticVariation BEFREE We observed interactions between trait anxiety and rs7209436 and rs110402 in CRHR1 in association with baseline cortisol (p LRT = 0.0272 and p LRT = 0.0483, respectively). 23274505 2013
Fragile X Syndrome
CUI: C0016667
Disease: Fragile X Syndrome
0.010 GeneticVariation BEFREE Results indicate a statistically significant interaction between CRHR1 genotype and the status of raising a child with FXS to predict social anxiety symptoms reported on the SPAI (rs7209436, P = 0.0001). 22573456 2012
Major Depressive Disorder
CUI: C1269683
Disease: Major Depressive Disorder
0.010 GeneticVariation BEFREE The T-A haplotype consisting of rs7209436 and rs110402 in CRHR1 was positively associated with MDD. 22467522 2012