|
Squamous cell carcinoma of skin
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Serous cystadenocarcinoma ovary
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Adenocarcinoma of pancreas
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Glioblastoma
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Mammary Neoplasms
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Neoplastic Syndromes, Hereditary
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Loss of MDM2 expression in human head and neck squamous cell carcinomas and clinical significance.
|
11590071 |
2001 |
|
High-Grade Squamous Intraepithelial Lesions
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, p53 arg/arg patients infected by an HPV16 prototype strain were associated with an increased risk of more severe lesions, while a significant relationship between the p53 arg/arg genotype in patients with T350G sequence variation and the risk of high-grade squamous intraepithelial lesions (HSILs) was revealed.<b>Conclusion.</b> The oncogenic potential of the virus is increased by the presence of the p53 arg/arg genotype in the Greek population in such a way that the specific protein interaction E6 (L83V)-p53 (Arg-72) can modify an individual's susceptibility to cervical disease.
|
28857739 |
2017 |
|
Cervix Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, p53 arg/arg patients infected by an HPV16 prototype strain were associated with an increased risk of more severe lesions, while a significant relationship between the p53 arg/arg genotype in patients with T350G sequence variation and the risk of high-grade squamous intraepithelial lesions (HSILs) was revealed.<b>Conclusion.</b> The oncogenic potential of the virus is increased by the presence of the p53 arg/arg genotype in the Greek population in such a way that the specific protein interaction E6 (L83V)-p53 (Arg-72) can modify an individual's susceptibility to cervical disease.
|
28857739 |
2017 |
|
B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1
|
|
0.010 |
GeneticVariation
|
BEFREE |
One patient with lymphoid BC/Ph+ ALL who harbored a T315I ABL mutation and was treated with ponatinib was found to have developed a newly acquired V216M TP53 mutation (12% of transcripts) when becoming resistant to ponatinib.
|
25894969 |
2015 |
|
Neoplastic Syndromes, Hereditary
|
|
0.700 |
GeneticVariation
|
CLINVAR |
p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma.
|
10949938 |
2000 |
|
Neoplastic Syndromes, Hereditary
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Revisiting Li-Fraumeni Syndrome From TP53 Mutation Carriers.
|
26014290 |
2015 |
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
The tumor was diagnosed as choroid plexus carcinoma with a novel TP53 V216M somatic mutation.
|
30099178 |
2018 |
|
Choroid Plexus Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The tumor was diagnosed as choroid plexus carcinoma with a novel TP53 V216M somatic mutation.
|
30099178 |
2018 |
|
Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results suggest that the natural variants, E6 D25E and L83V, similar to the prototype E6 protein, contribute to tumorigenesis by degrading p53.
|
23404471 |
2013 |
|
Neoplastic Syndromes, Hereditary
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Transactivation by temperature-dependent p53 mutants in yeast and human cells.
|
20505364 |
2010 |
|
Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two variants of E6 proteins, D25E and L83V, are common in cervical carcinomas among Asian and European populations.
|
23404471 |
2013 |
|
Li-Fraumeni Syndrome
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis.
|
12826609 |
2003 |