|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs738409 G allele was significantly associated with NAFLD (P < 0.001; OR 2.8 95%, CI 1.5-5.2), independent of age, sex, body mass index (BMI), and Homeostasis Model Assessment (HOMA) index.
|
19738004 |
2009 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our aims were to develop a method to accurately predict non-alcoholic fatty liver disease (NAFLD) and liver fat content based on routinely available clinical and laboratory data and to test whether knowledge of the recently discovered genetic variant in the PNPLA3 gene (rs738409) increases accuracy of the prediction.
|
19524579 |
2009 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis.
|
20034933 |
2010 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found that in the Japanese population, individuals harboring the G-allele of rs738409 were susceptible to NAFLD, and that rs738409 was associated with plasma levels of ALT, AST, and ferritin, and the histological fibrosis stage.
|
21176169 |
2010 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The G allele of rs738409 in PNPLA3 was associated with increased odds of histologic NAFLD (odds ratio [OR] = 3.26, 95% confidence intervals [CI] = 2.11-7.21; P = 3.6 x 10(-43)).
|
20648472 |
2010 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
After adjustment for age, sex, diabetes, and alcohol consumption, the minor allele of rs738409 C/G, a nonsynonymous coding SNP in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) (adiponutrin) gene encoding an Ile148Met change, was associated with steatosis (P = 0.03), portal inflammation (P = 2.5 x 10(-4)), lobular inflammation (P = 0.005), Mallory-Denk bodies (P = 0.015), NAFLD activity score (NAS, P = 0.004), and fibrosis (P = 7.7 x 10(-6)).
|
20684021 |
2010 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The PNPLA3 rs738409 polymorphism is associated with steatosis severity, hepatocellular ballooning, lobular inflammation, and perivenular fibrosis in pediatric NAFLD.
|
20648474 |
2010 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease.
|
20373368 |
2010 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Non-alcoholic fatty liver disease (NAFLD) is commonly diagnosed in patients with obesity and type 2 diabetes mellitus (T2DM), and has been associated with the single nucleotide polymorphism (SNP) rs738409 in the PNPLA3 gene.
|
21665509 |
2011 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
By summarizing the amount of evidence, this study provided unequivocal evidence of rs738409 as a strong modifier of the natural history of NAFLD in different populations around the world.
|
21381068 |
2011 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver disease.
|
21878620 |
2011 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
This study reports an association between the PNPLA3-I148M polymorphism and insulin resistance and NAFLD in a normoglycaemic population.
|
21745282 |
2011 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The variant PNPLA3 rs738409 genotypes increased the risk of NAFLD in our population of obese Taiwanese children.
|
21168155 |
2011 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A recent genome-wide association study identified a genetic variant in the patatin-like phospholipase-3 (PNPLA3) gene (rs738409 C>G) associated with steatosis that was further demonstrated to influence severity of fibrosis in nonalcoholic fatty liver disease.
|
21488075 |
2011 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
|
21423719 |
2011 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The PNPLA3 rs738409 C>G polymorphism has been found to be strongly associated with non-alcoholic fatty liver disease and with alcoholic liver disease.
|
21745286 |
2011 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liver.
|
21777557 |
2011 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently the common adiponutrin (PNPLA3) polymorphism p.I148M has been identified as a genetic determinant of severe forms of non-alcoholic fatty liver disease and alcoholic liver disease.
|
21893698 |
2011 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
|
21423719 |
2011 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Regarding the latter, a sequence variation within the gene coding for patatin-like phospholipase encoding 3 (PNPLA3, rs738409) was found to modulate steatosis, necroinflammation and fibrosis in NAFLD.
|
22110053 |
2012 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Moreover, a subgroup analysis of NAFLD patients against controls showed a significant association of rs738409 with type4 (p = 1.7 × 10(-16), OR = 2.18, 95%CI: 1.81-2.63) whereas no association was obtained for type1 to type3 (p = 0.41).
|
22719876 |
2012 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The I148M PNPLA3 variant is associated with adiponectin levels in patients with NAFLD and in healthy subjects, but in the presence of adiponectin resistance not in CHC patients.
|
22898488 |
2012 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In the multivariate logistic regression analysis, the rs738409 GG or GC, and rs139051 TT genotypes were found to be associated with increased risk of NAFLD, and a significant trend of increased risk with increasing numbers of risk genotype was observed in the cumulative effect analysis of these single nucleotide polymorphisms.
|
23226254 |
2012 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The development of an animal model that recapitulates the metabolic phenotype of the allele in humans provides a new platform in which to elucidate the role of PNLPA3(I148M) in NAFLD.
|
23023705 |
2012 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The interaction terms among alcohol, body mass index (BMI), and genotype were not significant. rs738409 GC or GG genotype was associated with 1.9-fold odds (95% confidence interval (CI), 1.2-2.9) of a higher NAFLD Activity Score (NAS).
|
23032985 |
2012 |