Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
General linear models were used to detect interactive effects between the PNPLA3 rs738409 genotype and 4 year changes in body weight on liver steatosis and glucose metabolism.
|
30673802 |
2019 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
There is an established correlation between the PNPLA3 rs738409 C > G single nucleotide polymorphism (SNP) and hepatic steatosis and fibrosis in hepatitis C virus (HCV) infected patients.
|
31642820 |
2019 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409 minor allele c.444G represents a risk factor for liver steatosis and fibrosis progression also in chronic hepatitis C (HCV).
|
31527889 |
2019 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis showed that PNPLA3 rs738409 polymorphism exerted strong influence not only on fatty liver but also on the histological injury.
|
30762732 |
2019 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Human immunodeficiency virus (HIV)-induced metabolic abnormalities and antiretroviral therapy (ART), genetic factors, most importantly the rs738409 C > G p.I148M variant in the patatin-like phospholipase domain containing 3 (PNPLA3)-gene, as well as hepatitis C virus (HCV) coinfection may all cause hepatic steatosis (HS).
|
31067123 |
2019 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409, GCKR rs780094 and TM6SF2 rs58542926 variants were independent risk factors of hepatic steatosis and elevated ALT levels.
|
29314568 |
2018 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of PNPLA3 rs738409 polymorphism with liver steatosis but not with cirrhosis in patients with HBV infection: Systematic review with meta-analysis.
|
29218813 |
2018 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PNPLA3 rs738409 GG donor genotype affects liver steatosis and steatohepatitis risk following living-donor LT.
|
28574625 |
2018 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Since DAG (FA18:1) has been implicated in hepatic insulin resistance, the unaltered proportion of DAG (FA18:1) in I148M PNPLA3 carriers with fatty liver may explain the normal insulin sensitivity in these subjects.
|
30227635 |
2018 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409 Polymorphism Predicts Development and Severity of Hepatic Steatosis but Not Metabolic Syndrome in Celiac Disease.
|
30189691 |
2018 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PNPLA3 rs738409 GG genotype is positively associated with HS, while the IFNL3 rs 12979860 CC genotype may be negatively associated with HS, in Asian CHC patients.
|
28797039 |
2017 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
We determined the frequency of PNPLA3 (rs738409), CSPG3/NCAN (rs2228603), GCKR (rs780094), PPP1R3B (rs4240624), TM6SF (rs8542926), LYPLAL1 (rs12137855) and MBOAT7 (rs626283) by RT-PCR in 117 HIV-positive patients on cART and stratified participants based on their "controlled attenuation parameter" (CAP) into probable (CAP: 215-300 dB/m) and definite (CAP >300 dB/m) hepatic steatosis.
|
28594920 |
2017 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among 270 HBV-infected patients, concurrent fatty liver was found in 107 patients (39.6%) and was associated with metabolic risks, cirrhosis (P = 0.016) and PNPLA3 rs738409 CG/GG genotype (P = 0.002).
|
27547913 |
2017 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Associations between the rs738409 polymorphism of the PNPLA3 gene genotype GG and hepatic steatosis and advanced fibrosis were observed.
|
29258449 |
2017 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409 Polymorphism Associated with Hepatic Steatosis and Advanced Fibrosis in Patients with Chronic Hepatitis C Virus: A Meta-Analysis.
|
26419236 |
2016 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Associations of the single nucleotide polymorphisms (SNP) PNPLA3 rs738409 and TM6SF2 rs58542926 with hepatic steatosis have recently been established.
|
26847197 |
2016 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409 G allele carriers were found to be more susceptible to the metabolic-related hepatic steatosis, and developed NAFLD and liver fibrosis despite presenting relatively better metabolic statuses and lower risks for carotid atherosclerosis.
|
26765961 |
2016 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Reduction of Caloric Intake Might Override the Prosteatotic Effects of the PNPLA3 p.I148M and TM6SF2 p.E167K Variants in Patients with Fatty Liver: Ultrasound-Based Prospective Study.
|
26745555 |
2016 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I148M variant has a strong impact on the full spectrum of liver damage related to fatty liver, encompassing non-alcoholic steatohepatitis, advanced fibrosis, and hepatocellular carcinoma, and influences the response to therapeutic approaches.
|
26409295 |
2016 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
A discrete trait analysis of NAFLD showed that rs58542926 was associated with a modest risk of fatty liver (P = 0.038; odds ratio [OR]: 1.37; 95% confidence interval [CI]: 1.02-1.84); nevertheless, conditioning on patatin-like phospholipase domain-containing 3 (PNPLA3)-rs738409 abolished this effect.
|
25302781 |
2015 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among the patients with BMI < 24 kg/m(2), carriage of the rs738409 GG genotype was the only factor associated with hepatic steatosis (OR/CI:3.44/1.824-6.500, P < 0.001).
|
26139292 |
2015 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of PNPLA3 p.I148M with liver steatosis increased with the greater amount of abdominal fat, irrespective of BMI.
|
25986529 |
2015 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PNPLA3 rs738409 variant influences histological liver damage in Japanese patients with chronic hepatitis C. The G allele homozygotes are at higher risk for hepatic steatosis, severe necroinflammation, and advanced fibrosis.
|
25543233 |
2015 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Impact of PNPLA3 rs738409 SNP on Liver Fibrosis Progression, Portal Hypertension and Hepatic Steatosis in HIV/HCV Coinfection.
|
26599080 |
2015 |
Fatty Liver
|
|
0.100 |
GeneticVariation
|
BEFREE |
To identify the impact of I148M variant on clinical risk factors of NAFLD, we recruited 1363 generally healthy Korean males after excluding alcoholic and secondary causes of hepatic steatosis.
|
26148225 |
2015 |