|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We genotyped 591 patients with obesity for PNPLA3 I148M polymorphism.
|
31184438 |
2019 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, PNPLA3 rs738409 may be more relevant to the progression of non-obese NAFLD when compared to obese NAFLD.
|
29609501 |
2018 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here we show that adiposity significantly amplifies the effect of three sequence variants (encoding PNPLA3 p.I148M, TM6SF2 p.E167K, and GCKR p.P446L) associated with nonalcoholic fatty liver disease (NAFLD).
|
28436986 |
2017 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
I148M variant of PNPLA3 increases the susceptibility to non-alcoholic fatty liver disease caused by obesity and metabolic disorders.
|
26765961 |
2016 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The objectives of this study were to investigate in a group of obese children the association among the 167K allele of TM6SF2 gene and ALT, cholesterol and triglycerides levels, and hepatic steatosis, and to evaluate the potential interaction between this variant and the I148M patatin like phospholipase 3 gene (PNPLA3) polymorphism on liver enzymes.
|
25893821 |
2016 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 I148M (rs738409) was genotyped by Taqman assay in 76 overweight/obese individuals [BMI (kg/m(2)) ≥25; mean ± SD age: 59.7 ± 11.4 y; male gender: 70%] with a histologic diagnosis of nonalcoholic fatty liver disease (NAFLD; namely the Milan NAFLD cohort) and in 413 obese men (BMI ≥30; mean ± SD age: 57.1 ± 4.9 y) from the α-Tocopherol, β-Carotene Cancer Prevention (ATBC) Study.
|
26136587 |
2015 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hence, overweight/o</span>bese rs738409 carriers should be identified early in life and treated with a rigorous life style intervention.
|
25939720 |
2015 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity.
|
24009255 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
To identify genetic risks for obesity and diabetes postliver transplantation (LT), LT recipients underwent genotyping for IL28B rs12979860 (n = 295) and PNPLA3 rs738409 (n = 205) polymorphism in both donors and recipients.
|
23859071 |
2013 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I148M PNPLA3 variant is strongly associated with elevated ALT levels in normal weight and overweight/obese Mexican children.
|
23510779 |
2013 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the study was to determine whether increased adipocyte size is associated with increased liver fat content due to nonalcoholic fatty liver disease (NAFLD) in humans independent of obesity, fat distribution and genetic variation in the patatin-like phospholipase domain-containing 3 gene (PNPLA3; adiponutrin) at rs738409.
|
23913731 |
2013 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this cohort of patients with medically complicated obesity, PNPLA3 rs738409 G allelic expression is associated with hepatic (NASH) and nonhepatic complications of obesity, such as insulin resistance.
|
23418085 |
2013 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, rs738409 C>G appeared to have a multiplicative joint effect with tea drinking (P<0.005) and an additive joint effect with obesity (Interaction contrast ratio (ICR) = 2.31, 95% CI: 0.7-8.86), hypertriglyceridemia (ICR = 3.07, 95% CI: 0.98-5.09) or hypertension (ICR = 1.74, 95% CI: 0.52-3.12).
|
23226254 |
2012 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Non-alcoholic fatty liver disease (NAFLD) is commonly diagnosed in patients with obesity and type 2 diabetes mellitus (T2DM), and has been associated with the single nucleotide polymorphism (SNP) rs738409 in the PNPLA3 gene.
|
21665509 |
2011 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Four hundred and seventy-five obese/overweight children and adolescents were genotyped for the I148M allele.
|
20546964 |
2010 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Both variant alleles were associated with decreased prevalence of obesity (P<0.05); odds ratio 0.75 (0.61-0.93) per carried Ile-allele for rs738409 and 0.80 (0.64-1.00) per carried G-allele for rs2072907.
|
18728122 |
2008 |