rs738409, PNPLA3

N. diseases: 88
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Hepatitis C, Chronic
CUI: C0524910
Disease: Hepatitis C, Chronic
0.100 GeneticVariation BEFREE PNPLA3 rs738409 minor allele c.444G represents a risk factor for liver steatosis and fibrosis progression also in chronic hepatitis C (HCV). 31527889 2019
Hepatitis C, Chronic
CUI: C0524910
Disease: Hepatitis C, Chronic
0.100 GeneticVariation BEFREE PNPLA3 rs738409 polymorphism is associated with liver fibrosis progression in patients with chronic hepatitis C: A repeated measures study. 29674183 2018
Hepatitis C, Chronic
CUI: C0524910
Disease: Hepatitis C, Chronic
0.100 GeneticVariation BEFREE A recent meta-analysis revealed that the genotype PNPLA3 rs738409 GG is associated with a higher risk of hepatic steatosis (HS) in Caucasian patients with chronic hepatitis C (CHC). 28797039 2017
Hepatitis C, Chronic
CUI: C0524910
Disease: Hepatitis C, Chronic
0.100 GeneticVariation BEFREE Levels of sMICA were highly correlated to liver disease severity in chronic hepatitis C patients who carried the MICA rs738409 A allele. 28427234 2017
Hepatitis C, Chronic
CUI: C0524910
Disease: Hepatitis C, Chronic
0.100 GeneticVariation BEFREE The rs738409 polymorphism of the PNPLA3 gene is associated with hepatic steatosis and fibrosis in Brazilian patients with chronic hepatitis C. 29258449 2017
Hepatitis C, Chronic
CUI: C0524910
Disease: Hepatitis C, Chronic
0.100 GeneticVariation BEFREE PNPLA3 rs738409 Polymorphism Associated with Hepatic Steatosis and Advanced Fibrosis in Patients with Chronic Hepatitis C Virus: A Meta-Analysis. 26419236 2016
Hepatitis C, Chronic
CUI: C0524910
Disease: Hepatitis C, Chronic
0.100 GeneticVariation BEFREE The PNPLA3 rs738409 variant influences histological liver damage in Japanese patients with chronic hepatitis C. The G allele homozygotes are at higher risk for hepatic steatosis, severe necroinflammation, and advanced fibrosis. 25543233 2015
Hepatitis C, Chronic
CUI: C0524910
Disease: Hepatitis C, Chronic
0.100 GeneticVariation BEFREE Duplex High-Resolution Melting Assay for the Simultaneous Genotyping of IL28B rs12979860 and PNPLA3 rs738409 Polymorphisms in Chronic Hepatitis C Patients. 26389885 2015
Hepatitis C, Chronic
CUI: C0524910
Disease: Hepatitis C, Chronic
0.100 GeneticVariation BEFREE The PNPLA3/Adiponutrin rs738409 C/G single nucleotide polymorphism is associated with the severity of steatosis, steatohepatitis and fibrosis in patients with non-alcoholic fatty liver disease, as well as the severity of steatosis and fibrosis in patients with chronic hepatitis C (CHC). 25801076 2015
Hepatitis C, Chronic
CUI: C0524910
Disease: Hepatitis C, Chronic
0.100 GeneticVariation BEFREE Interaction between PNPLA3 I148M variant and age at infection in determining fibrosis progression in chronic hepatitis C. 25171251 2014
Hepatitis C, Chronic
CUI: C0524910
Disease: Hepatitis C, Chronic
0.100 GeneticVariation BEFREE Variation at rs738409 was not associated with significant changes in resolution rate of hepatitis C. By contrast, M/M genotype, present at higher frequencies (22.8%) in HCC patients than in patients with chronic hepatitis C (8.5%, P = 0.004) or control individuals (9.1%, P = 0.005) was associated with a 3-fold increase of liver cancer risk. 24269995 2014
Hepatitis C, Chronic
CUI: C0524910
Disease: Hepatitis C, Chronic
0.100 GeneticVariation BEFREE Abdominal fat interacts with PNPLA3 I148M, but not with the APOC3 variant in the pathogenesis of liver steatosis in chronic hepatitis C. 23808989 2013
Hepatitis C, Chronic
CUI: C0524910
Disease: Hepatitis C, Chronic
0.100 GeneticVariation BEFREE Reduced adiponectin is implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH), and the I148M Patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism predisposes to NAFLD and liver damage progression in NASH and chronic hepatitis C (CHC) by still undefined mechanisms, possibly involving regulation of adipose tissue function. 22898488 2012
Hepatitis C, Chronic
CUI: C0524910
Disease: Hepatitis C, Chronic
0.100 GeneticVariation BEFREE Homozygosity for the PNPLA3 p.I148M polymorphism influences steatosis and fibrogenesis in chronic hepatitis C (CHC). 22530607 2012
Hepatitis C, Chronic
CUI: C0524910
Disease: Hepatitis C, Chronic
0.100 GeneticVariation BEFREE Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C. 21319195 2011
Hepatitis C, Chronic
CUI: C0524910
Disease: Hepatitis C, Chronic
0.100 GeneticVariation BEFREE Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C. 21488075 2011