|
Epilepsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The objective of this study was to determine whether three common genetic polymorphisms [apolipoprotein (APOE) ε4 (rs42938 and rs7412), brain derived neurotrophic factor (BDNF) Met (rs6265), and catechol-O-methyltransferase (COMT) Val (rs4680)] are associated with increased psychiatric symptomatology in individuals with pharmacoresistant epilepsy.
|
30909076 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
We evaluated the influence of CETP (rs5882 and rs708272), APOE (rs7412, rs429358) and LPL (rs328) gene polymorphisms on triglyceride (TG) response to oral fat tolerance test (OFTT) meal in patients with well-controlled type 2 diabetes mellitus (T2DM).
|
31585025 |
2019 |
|
Cerebral Vasospasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Data included demographic information, genetic sampling for the APOE gene and single-nucleotide polymorphisms (SNPs; rs405509, rs429358, rs7412), and daily transcranial Doppler ultrasounds to evaluate for CV.
|
29996665 |
2018 |
|
Hepatitis E
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, our results suggested that rs7412 C to T variation in APOE was significantly associated with lower risk of HEV infection in males (adjusted OR < 1.0, P < 0.05) but not in females.
|
29558945 |
2018 |
|
Age related macular degeneration
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study aimed to evaluate the association of AMD with ApoE gene polymorphism variants (rs7412 and rs429358).
|
29851526 |
2018 |
|
Hepatolenticular Degeneration
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two APOE cSNPs (rs429358 and rs7412) resulting in three isoforms and M129V (rs1799990) polymorphism of PRNP were examined for their association with WD and its clinical phenotypes.
|
29059476 |
2018 |
|
Hyperlipoproteinemia Type IIa
|
|
0.010 |
GeneticVariation
|
BEFREE |
The current study aimed to investigate the genetic association between FH disease and ApoE gene polymorphisms (rs429358 and rs7412) in the Saudi population.
|
30235358 |
2018 |
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
A total of nine gene variants/polymorphisms - F5 (Leiden - R5 06Q, rs6025), F2 (20210G > A, rs1799963), F13A1 (V34L, rs5985), MTHFR (677C > T - A222V, rs1801133), MTHFR (1298A > C - E429A, rs1801131), FGB (-455G > A -c.-463G > A; rs1800790), SERPINE1 (PAI14G/5G - rs1799889), ACE (ACE I/D, rs1799752), ITGB3 (GPIIIa L33P, rs5918) and the APOE E2/E3/E4 alleles (rs7412, rs429358) - were genotyped in 200 newly diagnosed ischemic stroke (IS) patients, 165 patients with ischemic coronary heart disease (CHD) and 159 controls with no cerebroor cardiovascular disease (non-CVD).
|
27629735 |
2016 |
|
AURAL ATRESIA, CONGENITAL
|
|
0.010 |
GeneticVariation
|
BEFREE |
We analyzed the genotypes frequency of APOA1 (rs5069, rs670), CLU (rs11136000, rs1532278, rs7012010, rs9331888) and APOE (rs429358, rs7412) in a cohort of patients with CAA-associated intracerebral hemorrhage (ICH) (n = 59) and compared the results with those from hypertension-associated ICH (n = 42), AD patients (n = 73) and controls (n = 88).
|
26661731 |
2016 |
|
Chronic Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The genomic DNA of 294 patients with CP and 175 healthy/non-periodontitis controls were genotyped, using the real-time polymerase chain reaction (RT-PCR) method, for ApoE (rs429358 and rs7412) gene polymorphisms.
|
25545672 |
2015 |
|
Dyslipidemias
|
|
0.010 |
GeneticVariation
|
BEFREE |
After taking into account confounding factors and correcting for multiple comparisons only APOE rs429358 and rs7412 variants remained significantly associated with risk of dyslipidemia.
|
26043189 |
2015 |
|
Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The genomic DNA of 294 patients with CP and 175 healthy/non-periodontitis controls were genotyped, using the real-time polymerase chain reaction (RT-PCR) method, for ApoE (rs429358 and rs7412) gene polymorphisms.
|
25545672 |
2015 |
|
Hypertriglyceridemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Variants more frequently identified in isolated hypertriglyceridemias were rs7412 in APOE and rs1800795 in IL6; rs2808607 in CYP7A1 and rs3812316 and rs17145738 in MLXIPL were more frequent in FCHL.
|
25176936 |
2014 |
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation
|
BEFREE |
We demonstrate that except of TG, Apo A5 T-1131C (rs662799) and Apo E (rs429358, rs7412) polymorphisms have no remarkable effect on MetS characteristics.
|
24709297 |
2014 |
|
Hyperlipidemia, Familial Combined
|
|
0.010 |
GeneticVariation
|
BEFREE |
Variants more frequently identified in isolated hypertriglyceridemias were rs7412 in APOE and rs1800795 in IL6; rs2808607 in CYP7A1 and rs3812316 and rs17145738 in MLXIPL were more frequent in FCHL.
|
25176936 |
2014 |
|
Diabetic Nephropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Analyses showed no significant effects of APOE rs7412 and APOE rs429358 on the frequencies of the allele and genotype between subjects with T2D with and without DN.
|
21689001 |
2011 |
|
Osteoporosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Disease association analysis revealed a susceptibility haplotype CGTC (in order of rs440446, rs769450, rs429358, rs7412) and the carriers of this haplotype has higher risk of osteopenia (OR 3.53, 95% CI 1.21-11.0, P=0.017) and osteoporosis (OR 3.61, 95% CI 1.53-9.48, P=0.002) after adjusting the confounding effect of age, BMI and years since menopause.
|
20663622 |
2010 |
|
Presenile dementia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We reach four principal conclusion from this study: 1) rs429358 alone is responsible for the association of APOE with dementia; 2) The association of APOE with dementia is substantially mediated by its effect on CNS Aß42 levels; 3) The association of APOE with dementia is not mediated by its impact on peripheral lipid metabolism; and 4) The dichotomy of effects of rs429358 and rs7412 represents one of the best examples of genetic pleiotropy for complex traits known and illustrates the importance of allelic heterogeneity in APOE.
|
20847432 |
2010 |
|
Osteopenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Disease association analysis revealed a susceptibility haplotype CGTC (in order of rs440446, rs769450, rs429358, rs7412) and the carriers of this haplotype has higher risk of osteopenia (OR 3.53, 95% CI 1.21-11.0, P=0.017) and osteoporosis (OR 3.61, 95% CI 1.53-9.48, P=0.002) after adjusting the confounding effect of age, BMI and years since menopause.
|
20663622 |
2010 |
|
Dementia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We reach four principal conclusion from this study: 1) rs429358 alone is responsible for the association of APOE with dementia; 2) The association of APOE with dementia is substantially mediated by its effect on CNS Aß42 levels; 3) The association of APOE with dementia is not mediated by its impact on peripheral lipid metabolism; and 4) The dichotomy of effects of rs429358 and rs7412 represents one of the best examples of genetic pleiotropy for complex traits known and illustrates the importance of allelic heterogeneity in APOE.
|
20847432 |
2010 |
|
Aortic Aneurysm, Abdominal
|
|
0.010 |
GeneticVariation
|
BEFREE |
Men heterozygote for the ApoE p.Arg176Cys polymorphism had slower AAA growth, odds ratio for AAA progression> or =median 0.41, 95% confidence intervals 0.21-0.80, p=0.01.
|
19818961 |
2010 |
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
In search of genetic markers of myocardial infarction (MI) risk, which have prognostic significance for Russians, we performed a replication study of MI association with genetic variants of <i>PCSK9</i> (rs562556), <i>APOE</i> (epsilon polymorphism, rs7412 and rs429358), <i>LPL</i> (rs320), <i>MTHFR</i> (rs1801133), <i>eNOS</i> (rs2070744), and the 9p21 region (rs1333049) in 405 patients with MI and 198 controls.
|
29340220 |
2019 |
|
Multiple Sclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The association of the MS severity score (MSSS) and APOE rs429358 and rs7412 was assessed across 3237 MS patients using linear regression analyses.
|
26669675 |
2015 |
|
Multiple Sclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Despite sufficient power to detect associations at genome-wide significance thresholds across a range of ORs, our analyses did not support a role of rs429358 or rs7412 on MS susceptibility.
|
22972946 |
2012 |
|
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
Of the 3 SNPs most significantly associated with MI, rs7412, which defines the Apo E2 isoform, was associated with both a lower Apo B/A1 ratio (P=1.0x10(-7)) and lower MI risk (P=0.0004).
|
20031563 |
2009 |